Jonathan A. Deane, et.al., Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation., Immunity, 2007, 27

http://rdf.ncbi.nlm.nih.gov/pubmed/17997333

Jonathan A. Deane, et.al., Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation., Immunity, 2007, 27

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Tlr7)6Boll
  http://metadb.riken.jp/db/mgi_rdf/MGI:5488498
• Tg(Tlr7)1Boll
  http://metadb.riken.jp/db/mgi_rdf/MGI:5444399

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased circulating tumor necrosis factor level_Tg(Tlr7)1Boll/0
  http://metadb.riken.jp/0008553IC57BL6TgTlr71Boll0TgTlr71Boll
• autoimmune response_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Tlr7<tm1Flv>/Y,X/Yaa
  http://metadb.riken.jp/0001844B6CgFcgr2btm1TtkTlr7tm1FlvYaaFcgr2btm1TtkFcgr2btm1TtkTlr7tm1FlvYXYaaFcgr2btm1TtkTlr7tm1FlvYaa
• premature death_X/Tg(Tlr7)6Boll
  http://metadb.riken.jp/0002083IC57BL6XTgTlr76BollTgTlr76Boll
• premature death_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Tlr7<tm1Flv>/Y,X/Yaa
  http://metadb.riken.jp/0002083B6CgFcgr2btm1TtkTlr7tm1FlvYaaFcgr2btm1TtkFcgr2btm1TtkTlr7tm1FlvYXYaaFcgr2btm1TtkTlr7tm1FlvYaa
• enlarged spleen_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Tlr7<tm1Flv>/Y,X/Yaa
  http://metadb.riken.jp/0000691B6CgFcgr2btm1TtkTlr7tm1FlvYaaFcgr2btm1TtkFcgr2btm1TtkTlr7tm1FlvYXYaaFcgr2btm1TtkTlr7tm1FlvYaa
• lung inflammation_X/Tg(Tlr7)6Boll
  http://metadb.riken.jp/0001861IC57BL6XTgTlr76BollTgTlr76Boll
• decreased splenocyte proliferation_Tlr7<tm1Flv>/Y
  http://metadb.riken.jp/0009335B6129S1Tlr7tm1FlvTlr7tm1FlvYTlr7tm1Flv
• enlarged spleen_X/Tg(Tlr7)6Boll
  http://metadb.riken.jp/0000691IC57BL6XTgTlr76BollTgTlr76Boll
• abnormal dendritic cell morphology_Tg(Tlr7)1Boll/0
  http://metadb.riken.jp/0005461IC57BL6TgTlr71Boll0TgTlr71Boll
• increased anti-nuclear antigen antibody level_Tg(Tlr7)1Boll/0
  http://metadb.riken.jp/0004794IC57BL6TgTlr71Boll0TgTlr71Boll
• enlarged spleen_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,X/Yaa
  http://metadb.riken.jp/0000691B6CgFcgr2btm1TtkYaaFcgr2btm1TtkFcgr2btm1TtkXYaaFcgr2btm1TtkYaa
• increased marginal zone B cell number_Tlr7<tm1Flv>/Y
  http://metadb.riken.jp/0008181B6129S1Tlr7tm1FlvTlr7tm1FlvYTlr7tm1Flv
• abnormal circulating chemokine level_Tg(Tlr7)1Boll/0
  http://metadb.riken.jp/0010209IC57BL6TgTlr71Boll0TgTlr71Boll
• increased circulating interleukin-6 level_Tg(Tlr7)1Boll/0
  http://metadb.riken.jp/0008596IC57BL6TgTlr71Boll0TgTlr71Boll
• increased anti-nuclear antigen antibody level_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,X/Yaa
  http://metadb.riken.jp/0004794B6CgFcgr2btm1TtkYaaFcgr2btm1TtkFcgr2btm1TtkXYaaFcgr2btm1TtkYaa
• increased splenocyte proliferation_X/Yaa
  http://metadb.riken.jp/0009336B6SBLeYaaXYaaYaa
• thrombocytopenia_Tg(Tlr7)1Boll/0
  http://metadb.riken.jp/0003179IC57BL6TgTlr71Boll0TgTlr71Boll
• autoimmune response_Tg(Tlr7)1Boll/0
  http://metadb.riken.jp/0001844IC57BL6TgTlr71Boll0TgTlr71Boll
• abnormal dendritic cell morphology_X/Tg(Tlr7)6Boll
  http://metadb.riken.jp/0005461IC57BL6XTgTlr76BollTgTlr76Boll
• autoimmune response_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,X/Yaa
  http://metadb.riken.jp/0001844B6CgFcgr2btm1TtkYaaFcgr2btm1TtkFcgr2btm1TtkXYaaFcgr2btm1TtkYaa
• abnormal B cell activation_X/Tg(Tlr7)6Boll
  http://metadb.riken.jp/0008217IC57BL6XTgTlr76BollTgTlr76Boll
• anemia_Tg(Tlr7)1Boll/0
  http://metadb.riken.jp/0001577IC57BL6TgTlr71Boll0TgTlr71Boll
• decreased marginal zone B cell number_X/Yaa
  http://metadb.riken.jp/0008182B6SBLeYaaXYaaYaa
• liver inflammation_Tg(Tlr7)1Boll/0
  http://metadb.riken.jp/0001860IC57BL6TgTlr71Boll0TgTlr71Boll
• abnormal spleen morphology_Tg(Tlr7)1Boll/0
  http://metadb.riken.jp/0000689IC57BL6TgTlr71Boll0TgTlr71Boll
• abnormal kidney morphology_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,X/Yaa
  http://metadb.riken.jp/0002135B6CgFcgr2btm1TtkYaaFcgr2btm1TtkFcgr2btm1TtkXYaaFcgr2btm1TtkYaa
• liver inflammation_X/Tg(Tlr7)6Boll
  http://metadb.riken.jp/0001860IC57BL6XTgTlr76BollTgTlr76Boll
• increased susceptibility to systemic lupus erythematosus_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,X/Yaa
  http://metadb.riken.jp/0004801B6CgFcgr2btm1TtkYaaFcgr2btm1TtkFcgr2btm1TtkXYaaFcgr2btm1TtkYaa
• increased anti-nuclear antigen antibody level_X/Tg(Tlr7)6Boll
  http://metadb.riken.jp/0004794IC57BL6XTgTlr76BollTgTlr76Boll
• abnormal splenocyte physiology_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Tlr7<tm1Flv>/Y,X/Yaa
  http://metadb.riken.jp/0009333B6CgFcgr2btm1TtkTlr7tm1FlvYaaFcgr2btm1TtkFcgr2btm1TtkTlr7tm1FlvYXYaaFcgr2btm1TtkTlr7tm1FlvYaa
• enlarged spleen_Tg(Tlr7)1Boll/0
  http://metadb.riken.jp/0000691IC57BL6TgTlr71Boll0TgTlr71Boll
• decreased spleen white pulp amount_Tg(Tlr7)1Boll/0
  http://metadb.riken.jp/0008479IC57BL6TgTlr71Boll0TgTlr71Boll
• premature death_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,X/Yaa
  http://metadb.riken.jp/0002083B6CgFcgr2btm1TtkYaaFcgr2btm1TtkFcgr2btm1TtkXYaaFcgr2btm1TtkYaa
• decreased marginal zone B cell number_X/Tg(Tlr7)6Boll
  http://metadb.riken.jp/0008182IC57BL6XTgTlr76BollTgTlr76Boll
• premature death_Tg(Tlr7)1Boll/0
  http://metadb.riken.jp/0002083IC57BL6TgTlr71Boll0TgTlr71Boll
• increased splenocyte proliferation_X/Tg(Tlr7)6Boll
  http://metadb.riken.jp/0009336IC57BL6XTgTlr76BollTgTlr76Boll
• increased mature B cell number_X/Tg(Tlr7)6Boll
  http://metadb.riken.jp/0008210IC57BL6XTgTlr76BollTgTlr76Boll
• glomerulonephritis_X/Tg(Tlr7)6Boll
  http://metadb.riken.jp/0002743IC57BL6XTgTlr76BollTgTlr76Boll
• increased susceptibility to systemic lupus erythematosus_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Tlr7<tm1Flv>/Y,X/Yaa
  http://metadb.riken.jp/0004801B6CgFcgr2btm1TtkTlr7tm1FlvYaaFcgr2btm1TtkFcgr2btm1TtkTlr7tm1FlvYXYaaFcgr2btm1TtkTlr7tm1FlvYaa
• autoimmune response_X/Tg(Tlr7)6Boll
  http://metadb.riken.jp/0001844IC57BL6XTgTlr76BollTgTlr76Boll
• abnormal B cell morphology_X/Tg(Tlr7)6Boll
  http://metadb.riken.jp/0004939IC57BL6XTgTlr76BollTgTlr76Boll
• abnormal kidney morphology_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Tlr7<tm1Flv>/Y,X/Yaa
  http://metadb.riken.jp/0002135B6CgFcgr2btm1TtkTlr7tm1FlvYaaFcgr2btm1TtkFcgr2btm1TtkTlr7tm1FlvYXYaaFcgr2btm1TtkTlr7tm1FlvYaa
• extramedullary hematopoiesis_Tg(Tlr7)1Boll/0
  http://metadb.riken.jp/0000240IC57BL6TgTlr71Boll0TgTlr71Boll
• glomerulonephritis_Tg(Tlr7)1Boll/0
  http://metadb.riken.jp/0002743IC57BL6TgTlr71Boll0TgTlr71Boll
• increased anti-nuclear antigen antibody level_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Tlr7<tm1Flv>/Y,X/Yaa
  http://metadb.riken.jp/0004794B6CgFcgr2btm1TtkTlr7tm1FlvYaaFcgr2btm1TtkFcgr2btm1TtkTlr7tm1FlvYXYaaFcgr2btm1TtkTlr7tm1FlvYaa
• abnormal T cell activation_X/Tg(Tlr7)6Boll
  http://metadb.riken.jp/0001828IC57BL6XTgTlr76BollTgTlr76Boll

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Tlr7)6Boll
  http://metadb.riken.jp/db/mgi_rdf/MGI:5488498
• Tg(Tlr7)1Boll
  http://metadb.riken.jp/db/mgi_rdf/MGI:5444399