Heinz G. Linhart, et.al., Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing., Genes & development, 2007, 21

http://rdf.ncbi.nlm.nih.gov/pubmed/18056424

Heinz G. Linhart, et.al., Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing., Genes & development, 2007, 21

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm12(tetO-Dnmt3a_i1)Jae>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5313408
• Col1a1<tm11(tetO-Dnmt3b_i6)Jae>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5313407
• Col1a1<tm10(tetO-Dnmt3b_i3)Jae>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5313406
• Col1a1<tm9(tetO-Dnmt3b_i1)Jae>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5313405

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased intestinal adenoma incidence_Apc<Min>/Apc<+>,Col1a1<tm9(tetO-Dnmt3b_i1)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002404I129S4SvJaeC57BL6C57BL6JApcMinApcCol1a1tm9tetODnmt3bi1JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorApcCol1a1tm9tetODnmt3bi1JaeCol1a1GtROSA26Sortm1rtTAM2JaeApcMinGtROSA26Sor
• increased tumor growth/size_Apc<Min>/Apc<+>,Col1a1<tm9(tetO-Dnmt3b_i1)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003721I129S4SvJaeC57BL6C57BL6JApcMinApcCol1a1tm9tetODnmt3bi1JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorApcCol1a1tm9tetODnmt3bi1JaeCol1a1GtROSA26Sortm1rtTAM2JaeApcMinGtROSA26Sor
• abnormal DNA methylation_Apc<Min>/Apc<+>,Col1a1<tm9(tetO-Dnmt3b_i1)Jae>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008877I129S4SvJaeC57BL6C57BL6JApcMinApcCol1a1tm9tetODnmt3bi1JaeCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorApcCol1a1tm9tetODnmt3bi1JaeCol1a1GtROSA26Sortm1rtTAM2JaeApcMinGtROSA26Sor

class

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm12(tetO-Dnmt3a_i1)Jae>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5313408
• Col1a1<tm11(tetO-Dnmt3b_i6)Jae>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5313407
• Col1a1<tm10(tetO-Dnmt3b_i3)Jae>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5313406
• Col1a1<tm9(tetO-Dnmt3b_i1)Jae>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5313405