Masaaki. Komatsu, et.al., Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice., Cell, 2007, 131

http://rdf.ncbi.nlm.nih.gov/pubmed/18083104

Masaaki. Komatsu, et.al., Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice., Cell, 2007, 131

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Sqstm1<tm1Keta>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3774352

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased neuron apoptosis_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Sqstm1<tm1Keta>/Sqstm1<tm1Keta>,Tg(Nes-cre)1Wme/0
  http://metadb.riken.jp/0003203I129C57BL6C57BL6NCrljCBACBAJNCrljAtg7tm1TchiAtg7tm1TchiSqstm1tm1KetaSqstm1tm1KetaTgNescre1Wme0TgNescre1WmeSqstm1tm1KetaAtg7tm1Tchi
• increased circulating alkaline phosphatase level_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Sqstm1<tm1Keta>/Sqstm1<tm1Keta>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002968I129C57BL6C57BL6NCrljCBACBAJNCrljAtg7tm1TchiAtg7tm1TchiSqstm1tm1KetaSqstm1tm1KetaTgMx1cre1Cgn0TgMx1cre1CgnAtg7tm1TchiSqstm1tm1Keta
• increased circulating alkaline phosphatase level_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002968IC57BL6CBAAtg7tm1TchiAtg7tm1TchiTgMx1cre1Cgn0Atg7tm1TchiTgMx1cre1Cgn
• axon degeneration_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Sqstm1<tm1Keta>/Sqstm1<tm1Keta>,Tg(Nes-cre)1Wme/0
  http://metadb.riken.jp/0005405I129C57BL6C57BL6NCrljCBACBAJNCrljAtg7tm1TchiAtg7tm1TchiSqstm1tm1KetaSqstm1tm1KetaTgNescre1Wme0TgNescre1WmeSqstm1tm1KetaAtg7tm1Tchi
• abnormal nervous system physiology_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Nes-cre)1Wme/0
  http://metadb.riken.jp/0003633IC57BL6CBAAtg7tm1TchiAtg7tm1TchiTgNescre1Wme0Atg7tm1TchiTgNescre1Wme
• increased hepatocyte proliferation_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003893IC57BL6CBAAtg7tm1TchiAtg7tm1TchiTgMx1cre1Cgn0Atg7tm1TchiTgMx1cre1Cgn
• abnormal autophagy_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008260IC57BL6CBAAtg7tm1TchiAtg7tm1TchiTgMx1cre1Cgn0Atg7tm1TchiTgMx1cre1Cgn
• increased circulating aspartate transaminase level_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Sqstm1<tm1Keta>/Sqstm1<tm1Keta>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005343I129C57BL6C57BL6NCrljCBACBAJNCrljAtg7tm1TchiAtg7tm1TchiSqstm1tm1KetaSqstm1tm1KetaTgMx1cre1Cgn0TgMx1cre1CgnAtg7tm1TchiSqstm1tm1Keta
• increased neuron apoptosis_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Nes-cre)1Wme/0
  http://metadb.riken.jp/0003203IC57BL6CBAAtg7tm1TchiAtg7tm1TchiTgNescre1Wme0Atg7tm1TchiTgNescre1Wme
• decreased Purkinje cell number_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Sqstm1<tm1Keta>/Sqstm1<tm1Keta>,Tg(Nes-cre)1Wme/0
  http://metadb.riken.jp/0000880I129C57BL6C57BL6NCrljCBACBAJNCrljAtg7tm1TchiAtg7tm1TchiSqstm1tm1KetaSqstm1tm1KetaTgNescre1Wme0TgNescre1WmeSqstm1tm1KetaAtg7tm1Tchi
• abnormal hepatocyte morphology_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000607IC57BL6CBAAtg7tm1TchiAtg7tm1TchiTgMx1cre1Cgn0Atg7tm1TchiTgMx1cre1Cgn
• axon degeneration_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Nes-cre)1Wme/0
  http://metadb.riken.jp/0005405IC57BL6CBAAtg7tm1TchiAtg7tm1TchiTgNescre1Wme0Atg7tm1TchiTgNescre1Wme
• absent cerebral cortex pyramidal cells_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Nes-cre)1Wme/0
  http://metadb.riken.jp/0009975IC57BL6CBAAtg7tm1TchiAtg7tm1TchiTgNescre1Wme0Atg7tm1TchiTgNescre1Wme
• absent hippocampus pyramidal cells_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Nes-cre)1Wme/0
  http://metadb.riken.jp/0009972IC57BL6CBAAtg7tm1TchiAtg7tm1TchiTgNescre1Wme0Atg7tm1TchiTgNescre1Wme
• decreased liver function_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Sqstm1<tm1Keta>/Sqstm1<tm1Keta>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003325I129C57BL6C57BL6NCrljCBACBAJNCrljAtg7tm1TchiAtg7tm1TchiSqstm1tm1KetaSqstm1tm1KetaTgMx1cre1Cgn0TgMx1cre1CgnAtg7tm1TchiSqstm1tm1Keta
• increased circulating alanine transaminase level_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Sqstm1<tm1Keta>/Sqstm1<tm1Keta>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002941I129C57BL6C57BL6NCrljCBACBAJNCrljAtg7tm1TchiAtg7tm1TchiSqstm1tm1KetaSqstm1tm1KetaTgMx1cre1Cgn0TgMx1cre1CgnAtg7tm1TchiSqstm1tm1Keta
• limb grasping_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Sqstm1<tm1Keta>/Sqstm1<tm1Keta>,Tg(Nes-cre)1Wme/0
  http://metadb.riken.jp/0001513I129C57BL6C57BL6NCrljCBACBAJNCrljAtg7tm1TchiAtg7tm1TchiSqstm1tm1KetaSqstm1tm1KetaTgNescre1Wme0TgNescre1WmeSqstm1tm1KetaAtg7tm1Tchi
• abnormal nervous system physiology_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Sqstm1<tm1Keta>/Sqstm1<tm1Keta>,Tg(Nes-cre)1Wme/0
  http://metadb.riken.jp/0003633I129C57BL6C57BL6NCrljCBACBAJNCrljAtg7tm1TchiAtg7tm1TchiSqstm1tm1KetaSqstm1tm1KetaTgNescre1Wme0TgNescre1WmeSqstm1tm1KetaAtg7tm1Tchi
• abnormal hepatocyte morphology_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Sqstm1<tm1Keta>/Sqstm1<tm1Keta>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000607I129C57BL6C57BL6NCrljCBACBAJNCrljAtg7tm1TchiAtg7tm1TchiSqstm1tm1KetaSqstm1tm1KetaTgMx1cre1Cgn0TgMx1cre1CgnAtg7tm1TchiSqstm1tm1Keta
• increased circulating aspartate transaminase level_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005343IC57BL6CBAAtg7tm1TchiAtg7tm1TchiTgMx1cre1Cgn0Atg7tm1TchiTgMx1cre1Cgn
• abnormal autophagy_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Nes-cre)1Wme/0
  http://metadb.riken.jp/0008260IC57BL6CBAAtg7tm1TchiAtg7tm1TchiTgNescre1Wme0Atg7tm1TchiTgNescre1Wme
• tremors_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Sqstm1<tm1Keta>/Sqstm1<tm1Keta>,Tg(Nes-cre)1Wme/0
  http://metadb.riken.jp/0000745I129C57BL6C57BL6NCrljCBACBAJNCrljAtg7tm1TchiAtg7tm1TchiSqstm1tm1KetaSqstm1tm1KetaTgNescre1Wme0TgNescre1WmeSqstm1tm1KetaAtg7tm1Tchi
• decreased liver function_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003325IC57BL6CBAAtg7tm1TchiAtg7tm1TchiTgMx1cre1Cgn0Atg7tm1TchiTgMx1cre1Cgn
• limb grasping_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Nes-cre)1Wme/0
  http://metadb.riken.jp/0001513IC57BL6CBAAtg7tm1TchiAtg7tm1TchiTgNescre1Wme0Atg7tm1TchiTgNescre1Wme
• absent hippocampus pyramidal cells_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Sqstm1<tm1Keta>/Sqstm1<tm1Keta>,Tg(Nes-cre)1Wme/0
  http://metadb.riken.jp/0009972I129C57BL6C57BL6NCrljCBACBAJNCrljAtg7tm1TchiAtg7tm1TchiSqstm1tm1KetaSqstm1tm1KetaTgNescre1Wme0TgNescre1WmeSqstm1tm1KetaAtg7tm1Tchi
• tremors_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Nes-cre)1Wme/0
  http://metadb.riken.jp/0000745IC57BL6CBAAtg7tm1TchiAtg7tm1TchiTgNescre1Wme0Atg7tm1TchiTgNescre1Wme
• increased susceptibility to age related obesity_Sqstm1<tm1Keta>/Sqstm1<tm1Keta>
  http://metadb.riken.jp/0003212I129Sqstm1tm1KetaSqstm1tm1KetaSqstm1tm1Keta
• hyperglycemia_Sqstm1<tm1Keta>/Sqstm1<tm1Keta>
  http://metadb.riken.jp/0001559I129Sqstm1tm1KetaSqstm1tm1KetaSqstm1tm1Keta
• increased circulating alanine transaminase level_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002941IC57BL6CBAAtg7tm1TchiAtg7tm1TchiTgMx1cre1Cgn0Atg7tm1TchiTgMx1cre1Cgn
• absent cerebral cortex pyramidal cells_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Sqstm1<tm1Keta>/Sqstm1<tm1Keta>,Tg(Nes-cre)1Wme/0
  http://metadb.riken.jp/0009975I129C57BL6C57BL6NCrljCBACBAJNCrljAtg7tm1TchiAtg7tm1TchiSqstm1tm1KetaSqstm1tm1KetaTgNescre1Wme0TgNescre1WmeSqstm1tm1KetaAtg7tm1Tchi
• increased liver weight_Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002981IC57BL6CBAAtg7tm1TchiAtg7tm1TchiTgMx1cre1Cgn0Atg7tm1TchiTgMx1cre1Cgn

class

http://purl.org/net/cito/citesAsAuthority

• Sqstm1<tm1Keta>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3774352