Sebastian J. Arnold, et.al., Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse., Development (Cambridge, England), 2008, 135

http://rdf.ncbi.nlm.nih.gov/pubmed/18171685

Sebastian J. Arnold, et.al., Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse., Development (Cambridge, England), 2008, 135

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Eomes<tm1.1Rob>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3774028
• Eomes<tm1Rob>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3774027

class

http://purl.org/net/cito/citesAsAuthority

• Eomes<tm1.1Rob>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3774028
• Eomes<tm1Rob>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3774027

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• embryonic-extraembryonic boundary constriction_Eomes<tm1.1Rob>/Eomes<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0012135I129SSvEv129S7SvEvBrdC57BL6CBAEomestm11RobEomesNodaltm1RobNodalNodalEomestm11RobNodaltm1RobEomes
• abnormal germ layer development_Eomes<tm1.1Rob>/Eomes<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0001674I129SSvEv129S7SvEvBrdC57BL6CBAEomestm11RobEomesNodaltm1RobNodalNodalEomestm11RobNodaltm1RobEomes
• absent mesoderm_Eomes<tm1Rob>/Eomes<tm1.1Rob>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0001683I129SSvEvC57BL6CBAEomestm1RobEomestm11RobTgSox2cre1Amc0Eomestm11RobTgSox2cre1AmcEomestm1Rob
• embryonic lethality between implantation and somite formation, complete penetrance_Eomes<tm1.1Rob>/Eomes<tm1.1Rob>
  http://metadb.riken.jp/0011096I129SSvEvC57BL6CBAEomestm11RobEomestm11RobEomestm11Rob
• increased somite number_Eomes<tm1.1Rob>/Eomes<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0012181I129SSvEv129S7SvEvBrdC57BL6CBAEomestm11RobEomesNodaltm1RobNodalNodalEomestm11RobNodaltm1RobEomes
• abnormal anterior visceral endoderm cell migration_Eomes<tm1.1Rob>/Eomes<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0011255I129SSvEv129S7SvEvBrdC57BL6CBAEomestm11RobEomesNodaltm1RobNodalNodalEomestm11RobNodaltm1RobEomes
• no abnormal phenotype detected_Eomes<tm1.1Rob>/Eomes<+>,Nodal<tm4Rob>/Nodal<tm4Rob>
  http://metadb.riken.jp/0002169I129SSvEvC57BL6CBAEomestm11RobEomesNodaltm4RobNodaltm4RobEomestm11RobEomesNodaltm4Rob
• enlarged floor plate_Eomes<tm1.1Rob>/Eomes<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0012675I129SSvEv129S7SvEvBrdC57BL6CBAEomestm11RobEomesNodaltm1RobNodalNodalEomestm11RobNodaltm1RobEomes
• abnormal visceral endoderm morphology_Eomes<tm1Rob>/Eomes<tm1.1Rob>,Gt(ROSA)26Sor<tm1Sor>/Gt(ROSA)26Sor<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0011186I129SSvEv129S4SvJaeC57BL6CBAEomestm1RobEomestm11RobGtROSA26Sortm1SorGtROSA26SorTgSox2cre1Amc0Eomestm11RobGtROSA26Sortm1SorTgSox2cre1AmcGtROSA26SorEomestm1Rob
• failure of primitive streak formation_Eomes<tm1.1Rob>/Eomes<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0001693I129SSvEv129S7SvEvBrdC57BL6CBAEomestm11RobEomesNodaltm1RobNodalNodalEomestm11RobNodaltm1RobEomes
• abnormal trophoblast layer morphology_Eomes<tm1.1Rob>/Eomes<tm1.1Rob>
  http://metadb.riken.jp/0005031I129SSvEvC57BL6CBAEomestm11RobEomestm11RobEomestm11Rob
• abnormal embryonic epiblast morphology_Eomes<tm1Rob>/Eomes<tm1.1Rob>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0003886I129SSvEvC57BL6CBAEomestm1RobEomestm11RobTgSox2cre1Amc0Eomestm11RobTgSox2cre1AmcEomestm1Rob
• abnormal developmental patterning_Eomes<tm1.1Rob>/Eomes<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0002084I129SSvEv129S7SvEvBrdC57BL6CBAEomestm11RobEomesNodaltm1RobNodalNodalEomestm11RobNodaltm1RobEomes
• abnormal amniotic cavity morphology_Eomes<tm1.1Rob>/Eomes<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0011199I129SSvEv129S7SvEvBrdC57BL6CBAEomestm11RobEomesNodaltm1RobNodalNodalEomestm11RobNodaltm1RobEomes
• abnormal endoderm development_Eomes<tm1Rob>/Eomes<tm1.1Rob>,Gt(ROSA)26Sor<tm1Sor>/Gt(ROSA)26Sor<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0001685I129SSvEv129S4SvJaeC57BL6CBAEomestm1RobEomestm11RobGtROSA26Sortm1SorGtROSA26SorTgSox2cre1Amc0Eomestm11RobGtROSA26Sortm1SorTgSox2cre1AmcGtROSA26SorEomestm1Rob
• abnormal primitive node morphology_Eomes<tm1.1Rob>/Eomes<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0004066I129SSvEv129S7SvEvBrdC57BL6CBAEomestm11RobEomesNodaltm1RobNodalNodalEomestm11RobNodaltm1RobEomes
• disorganized embryonic tissue_Eomes<tm1.1Rob>/Eomes<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0003988I129SSvEv129S7SvEvBrdC57BL6CBAEomestm11RobEomesNodaltm1RobNodalNodalEomestm11RobNodaltm1RobEomes
• abnormal rostral-caudal patterning of the somites_Eomes<tm1.1Rob>/Eomes<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0008530I129SSvEv129S7SvEvBrdC57BL6CBAEomestm11RobEomesNodaltm1RobNodalNodalEomestm11RobNodaltm1RobEomes
• prenatal lethality_Eomes<tm1Rob>/Eomes<+>,Nodal<tm1Rob>/Nodal<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0002080I129SSvEvC57BL6CBAEomestm1RobEomesNodaltm1RobNodalTgSox2cre1Amc0Eomestm1RobEomesNodalNodaltm1RobTgSox2cre1Amc
• no abnormal phenotype detected_Eomes<tm1.1Rob>/Eomes<+>,Wnt3<tm1Brd>/Wnt3<+>
  http://metadb.riken.jp/0002169I129SSvEv129S7SvEvBrdC57BL6CBAEomestm11RobEomesWnt3tm1BrdWnt3EomesWnt3Wnt3tm1BrdEomestm11Rob
• rostral body truncation_Eomes<tm1.1Rob>/Eomes<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0012157I129SSvEv129S7SvEvBrdC57BL6CBAEomestm11RobEomesNodaltm1RobNodalNodalEomestm11RobNodaltm1RobEomes
• rostral-caudal axis duplication_Eomes<tm1.1Rob>/Eomes<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0012156I129SSvEv129S7SvEvBrdC57BL6CBAEomestm11RobEomesNodaltm1RobNodalNodalEomestm11RobNodaltm1RobEomes
• abnormal notochord morphology_Eomes<tm1.1Rob>/Eomes<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0002825I129SSvEv129S7SvEvBrdC57BL6CBAEomestm11RobEomesNodaltm1RobNodalNodalEomestm11RobNodaltm1RobEomes
• rostral body truncation_Eomes<tm1Rob>/Eomes<+>,Nodal<tm1Rob>/Nodal<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0012157I129SSvEvC57BL6CBAEomestm1RobEomesNodaltm1RobNodalTgSox2cre1Amc0Eomestm1RobEomesNodalNodaltm1RobTgSox2cre1Amc
• no abnormal phenotype detected_Eomes<tm1Rob>/Eomes<tm1Rob>
  http://metadb.riken.jp/0002169I129SSvEvEomestm1RobEomestm1RobEomestm1Rob
• abnormal left-right axis patterning_Eomes<tm1.1Rob>/Eomes<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0001706I129SSvEv129S7SvEvBrdC57BL6CBAEomestm11RobEomesNodaltm1RobNodalNodalEomestm11RobNodaltm1RobEomes
• abnormal primitive streak morphology_Eomes<tm1Rob>/Eomes<tm1.1Rob>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0002231I129SSvEvC57BL6CBAEomestm1RobEomestm11RobTgSox2cre1Amc0Eomestm11RobTgSox2cre1AmcEomestm1Rob