Edward C. Hsiao, et.al., Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass., Proceedings of the National Academy of Sciences of the United States of America, 2008, 105

http://rdf.ncbi.nlm.nih.gov/pubmed/18212126

Edward C. Hsiao, et.al., Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass., Proceedings of the National Academy of Sciences of the United States of America, 2008, 105

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-HTR4*D100A)2Niss
  http://metadb.riken.jp/db/mgi_rdf/MGI:4367596
• Tg(tetO-HTR4*D100A)7Niss
  http://metadb.riken.jp/db/mgi_rdf/MGI:4367585

class

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-HTR4*D100A)2Niss
  http://metadb.riken.jp/db/mgi_rdf/MGI:4367596
• Tg(tetO-HTR4*D100A)7Niss
  http://metadb.riken.jp/db/mgi_rdf/MGI:4367585

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal skeleton morphology_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0005508FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss
• premature death_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0002083FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss
• increased bone volume_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0010875FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss
• increased bone mineral density_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)2Niss/0
  http://metadb.riken.jp/0000062FVBNTgCol1a1tTA139NissTgtetOHTR4D100A2NissTgCol1a1tTA139Niss0TgtetOHTR4D100A2Niss0TgCol1a1tTA139NissTgtetOHTR4D100A2Niss
• abnormal skeleton morphology_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)2Niss/0
  http://metadb.riken.jp/0005508FVBNTgCol1a1tTA139NissTgtetOHTR4D100A2NissTgCol1a1tTA139Niss0TgtetOHTR4D100A2Niss0TgCol1a1tTA139NissTgtetOHTR4D100A2Niss
• abnormal skeleton development_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0002113FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss
• increased osteoblast cell number_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0004988FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss
• abnormal bone marrow morphology_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0002397FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss
• decreased compact bone mass_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0010962FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss
• increased areal bone mineral density_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0013617FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss
• abnormal cranium morphology_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0000438FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss
• decreased body height_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0001255FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss
• increased osteoclast cell number_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0004984FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss
• abnormal vertebral column morphology_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0004703FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss
• increased bone mineral density_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0000062FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss
• osteosclerosis_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0005422FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss
• abnormal trabecular bone morphology_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0000130FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss
• abnormal bone marrow cavity morphology_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0000065FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss
• decreased body height_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)2Niss/0
  http://metadb.riken.jp/0001255FVBNTgCol1a1tTA139NissTgtetOHTR4D100A2NissTgCol1a1tTA139Niss0TgtetOHTR4D100A2Niss0TgCol1a1tTA139NissTgtetOHTR4D100A2Niss
• abnormal femur morphology_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0000559FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss
• osteosclerosis_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)2Niss/0
  http://metadb.riken.jp/0005422FVBNTgCol1a1tTA139NissTgtetOHTR4D100A2NissTgCol1a1tTA139Niss0TgtetOHTR4D100A2Niss0TgCol1a1tTA139NissTgtetOHTR4D100A2Niss
• increased trabecular bone volume_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0010878FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss
• increased diameter of femur_Tg(Col1a1-tTA)139Niss/0,Tg(tetO-HTR4*D100A)7Niss/0
  http://metadb.riken.jp/0008158FVBNTgCol1a1tTA139NissTgtetOHTR4D100A7NissTgCol1a1tTA139Niss0TgtetOHTR4D100A7Niss0TgtetOHTR4D100A7NissTgCol1a1tTA139Niss