Aram F. Hezel, et.al., Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms., Molecular and cellular biology, 2008, 28

http://rdf.ncbi.nlm.nih.gov/pubmed/18227155

Aram F. Hezel, et.al., Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms., Molecular and cellular biology, 2008, 28

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased pancreatic delta cell number_Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0009181I129S6SvEvTacC57BL6CBAFVBNICRStk11tm11RdpStk11tm11RdpTgPdx1cre891Dam0TgPdx1cre891DamStk11tm11Rdp
• increased circulating glucose level_Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0005559I129S6SvEvTacC57BL6CBAFVBNICRStk11tm11RdpStk11tm11RdpTgPdx1cre891Dam0TgPdx1cre891DamStk11tm11Rdp
• pancreas fibrosis_Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0003334I129S6SvEvTacC57BL6CBAFVBNICRStk11tm11RdpStk11tm11RdpTgPdx1cre891Dam0TgPdx1cre891DamStk11tm11Rdp
• increased pancreas apoptosis_Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0013220I129S6SvEvTacC57BL6CBAFVBNICRStk11tm11RdpStk11tm11RdpTgPdx1cre891Dam0TgPdx1cre891DamStk11tm11Rdp
• abnormal pancreatic acinar cell morphology_Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0009146I129S6SvEvTacC57BL6CBAFVBNICRStk11tm11RdpStk11tm11RdpTgPdx1cre891Dam0TgPdx1cre891DamStk11tm11Rdp
• small pancreatic islets_Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0009172I129S6SvEvTacC57BL6CBAFVBNICRStk11tm11RdpStk11tm11RdpTgPdx1cre891Dam0TgPdx1cre891DamStk11tm11Rdp
• abnormal pancreatic acinus morphology_Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0009145I129S6SvEvTacC57BL6CBAFVBNICRStk11tm11RdpStk11tm11RdpTgPdx1cre891Dam0TgPdx1cre891DamStk11tm11Rdp
• decreased pancreatic alpha cell number_Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0009177I129S6SvEvTacC57BL6CBAFVBNICRStk11tm11RdpStk11tm11RdpTgPdx1cre891Dam0TgPdx1cre891DamStk11tm11Rdp
• improved glucose tolerance_Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0005292I129S6SvEvTacC57BL6CBAFVBNICRStk11tm11RdpStk11tm11RdpTgPdx1cre891Dam0TgPdx1cre891DamStk11tm11Rdp
• small pancreas_Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0004247I129S6SvEvTacC57BL6CBAFVBNICRStk11tm11RdpStk11tm11RdpTgPdx1cre891Dam0TgPdx1cre891DamStk11tm11Rdp
• abnormal exocrine pancreas morphology_Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0005220I129S6SvEvTacC57BL6CBAFVBNICRStk11tm11RdpStk11tm11RdpTgPdx1cre891Dam0TgPdx1cre891DamStk11tm11Rdp
• abnormal pancreatic islet morphology_Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0005215I129S6SvEvTacC57BL6CBAFVBNICRStk11tm11RdpStk11tm11RdpTgPdx1cre891Dam0TgPdx1cre891DamStk11tm11Rdp
• pancreas inflammation_Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0001869I129S6SvEvTacC57BL6CBAFVBNICRStk11tm11RdpStk11tm11RdpTgPdx1cre891Dam0TgPdx1cre891DamStk11tm11Rdp
• decreased pancreatic beta cell number_Stk11<tm1.1Rdp>/Stk11<tm1.1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0003339I129S6SvEvTacC57BL6CBAFVBNICRStk11tm11RdpStk11tm11RdpTgPdx1cre891Dam0TgPdx1cre891DamStk11tm11Rdp

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD04689
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD04689
• CD31708
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD31708
• CD00314
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00314
• CD06940
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD06940
• CD08611
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD08611