Li. Li, et.al., Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model., Blood, 2008, 111

http://rdf.ncbi.nlm.nih.gov/pubmed/18245664

Li. Li, et.al., Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model., Blood, 2008, 111

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Flt3<tm1Dosm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3783339

class

http://purl.org/net/cito/citesAsAuthority

• Flt3<tm1Dosm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3783339

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased leukocyte cell number_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000218B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• increased neutrophil cell number_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000219B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• increased monocyte cell number_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000220B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• decreased leukocyte cell number_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000221B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• decreased neutrophil cell number_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000222B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• extramedullary hematopoiesis_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000240B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
他19件を見る
• increased bone marrow cell number_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000321B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• increased granulocyte number_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000322B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• enlarged spleen_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• arrested B cell differentiation_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001802B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• premature death_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• abnormal definitive hematopoiesis_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002123B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• abnormal spleen white pulp morphology_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002357B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• abnormal bone marrow cell morphology/development_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002398B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• decreased hemoglobin content_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002874B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• decreased erythrocyte cell number_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002875B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• increased hematopoietic stem cell number_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004809B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• decreased lymphocyte cell number_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005016B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• decreased B cell number_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005017B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• delayed cellular replicative senescence_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008009B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• increased dendritic cell number_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008126B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• increased pro-B cell number_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008186B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• decreased pre-B cell number_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008209B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• decreased megakaryocyte cell number_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008255B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn
• intermingled spleen red and white pulp_Flt3<tm1Dosm>/Flt3<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008475B6CgFlt3tm1DosmTgMx1cre1CgnFlt3tm1DosmFlt3TgMx1cre1Cgn0Flt3tm1DosmFlt3TgMx1cre1Cgn