Ji-Yeon. Lee, et.al., Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity., PloS one, 2008, 3

http://rdf.ncbi.nlm.nih.gov/pubmed/18286195

Ji-Yeon. Lee, et.al., Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity., PloS one, 2008, 3

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• impaired glucose tolerance_Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0005293I129129S6SvEvTacC57BL6SJLStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5btm1MamTgNescre1Kln
• increased circulating triglyceride level_Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001552I129129S6SvEvTacC57BL6SJLStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5btm1MamTgNescre1Kln
• increased percent body fat/body weight_Stat5a<tm2Mam>/Stat5a<tm2Mam>,Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0005458I129129S6SvEvTacC57BL6SJLStat5atm2MamStat5atm2MamStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5atm2MamStat5btm1MamTgNescre1Kln
• increased total body fat amount_Stat5a<tm2Mam>/Stat5a<tm2Mam>,Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0010024I129129S6SvEvTacC57BL6SJLStat5atm2MamStat5atm2MamStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5atm2MamStat5btm1MamTgNescre1Kln
• polyphagia_Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001433I129129S6SvEvTacC57BL6SJLStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5btm1MamTgNescre1Kln
• increased lean body mass_Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0003960I129129S6SvEvTacC57BL6SJLStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5btm1MamTgNescre1Kln
• insulin resistance_Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0005331I129129S6SvEvTacC57BL6SJLStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5btm1MamTgNescre1Kln
• increased percent body fat/body weight_Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0005458I129129S6SvEvTacC57BL6SJLStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5btm1MamTgNescre1Kln
• impaired glucose tolerance_Stat5a<tm2Mam>/Stat5a<tm2Mam>,Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0005293I129129S6SvEvTacC57BL6SJLStat5atm2MamStat5atm2MamStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5atm2MamStat5btm1MamTgNescre1Kln
• impaired adaptive thermogenesis_Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0011049I129129S6SvEvTacC57BL6SJLStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5btm1MamTgNescre1Kln
• increased total body fat amount_Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0010024I129129S6SvEvTacC57BL6SJLStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5btm1MamTgNescre1Kln
• increased total fat pad weight_Stat5a<tm2Mam>/Stat5a<tm2Mam>,Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0008908I129129S6SvEvTacC57BL6SJLStat5atm2MamStat5atm2MamStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5atm2MamStat5btm1MamTgNescre1Kln
• increased circulating leptin level_Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0005669I129129S6SvEvTacC57BL6SJLStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5btm1MamTgNescre1Kln
• increased circulating leptin level_Stat5a<tm2Mam>/Stat5a<tm2Mam>,Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0005669I129129S6SvEvTacC57BL6SJLStat5atm2MamStat5atm2MamStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5atm2MamStat5btm1MamTgNescre1Kln
• increased circulating insulin level_Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002079I129129S6SvEvTacC57BL6SJLStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5btm1MamTgNescre1Kln
• increased circulating free fatty acid level_Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001554I129129S6SvEvTacC57BL6SJLStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5btm1MamTgNescre1Kln
• decreased oxygen consumption_Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0005290I129129S6SvEvTacC57BL6SJLStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5btm1MamTgNescre1Kln
• increased total fat pad weight_Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0008908I129129S6SvEvTacC57BL6SJLStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5btm1MamTgNescre1Kln
• decreased oxygen consumption_Stat5a<tm2Mam>/Stat5a<tm2Mam>,Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0005290I129129S6SvEvTacC57BL6SJLStat5atm2MamStat5atm2MamStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5atm2MamStat5btm1MamTgNescre1Kln
• abnormal fat pad morphology_Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0005334I129129S6SvEvTacC57BL6SJLStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5btm1MamTgNescre1Kln
• increased circulating triglyceride level_Stat5a<tm2Mam>/Stat5a<tm2Mam>,Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001552I129129S6SvEvTacC57BL6SJLStat5atm2MamStat5atm2MamStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5atm2MamStat5btm1MamTgNescre1Kln
• insulin resistance_Stat5a<tm2Mam>/Stat5a<tm2Mam>,Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0005331I129129S6SvEvTacC57BL6SJLStat5atm2MamStat5atm2MamStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5atm2MamStat5btm1MamTgNescre1Kln
• increased circulating insulin level_Stat5a<tm2Mam>/Stat5a<tm2Mam>,Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002079I129129S6SvEvTacC57BL6SJLStat5atm2MamStat5atm2MamStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5atm2MamStat5btm1MamTgNescre1Kln
• obese_Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001261I129129S6SvEvTacC57BL6SJLStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5btm1MamTgNescre1Kln
• increased lean body mass_Stat5a<tm2Mam>/Stat5a<tm2Mam>,Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0003960I129129S6SvEvTacC57BL6SJLStat5atm2MamStat5atm2MamStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5atm2MamStat5btm1MamTgNescre1Kln
• increased circulating free fatty acid level_Stat5a<tm2Mam>/Stat5a<tm2Mam>,Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001554I129129S6SvEvTacC57BL6SJLStat5atm2MamStat5atm2MamStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5atm2MamStat5btm1MamTgNescre1Kln
• polyphagia_Stat5a<tm2Mam>/Stat5a<tm2Mam>,Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001433I129129S6SvEvTacC57BL6SJLStat5atm2MamStat5atm2MamStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5atm2MamStat5btm1MamTgNescre1Kln
• obese_Stat5a<tm2Mam>/Stat5a<tm2Mam>,Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001261I129129S6SvEvTacC57BL6SJLStat5atm2MamStat5atm2MamStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5atm2MamStat5btm1MamTgNescre1Kln
• abnormal fat pad morphology_Stat5a<tm2Mam>/Stat5a<tm2Mam>,Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0005334I129129S6SvEvTacC57BL6SJLStat5atm2MamStat5atm2MamStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5atm2MamStat5btm1MamTgNescre1Kln
• impaired adaptive thermogenesis_Stat5a<tm2Mam>/Stat5a<tm2Mam>,Stat5b<tm1Mam>/Stat5b<tm1Mam>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0011049I129129S6SvEvTacC57BL6SJLStat5atm2MamStat5atm2MamStat5btm1MamStat5btm1MamTgNescre1Kln0Stat5atm2MamStat5btm1MamTgNescre1Kln