Sandra. Gardam, et.al., TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor., Immunity, 2008, 28

http://rdf.ncbi.nlm.nih.gov/pubmed/18313334

Sandra. Gardam, et.al., TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor., Immunity, 2008, 28

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Traf3<tm1.1Rbr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3777325
• Traf3<tm1Rbr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3777324

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased CD8-positive, alpha-beta T cell number_Tg(Lck-cre)I57Jxm/?,Traf3<tm1Rbr>/Traf3<tm1Rbr>
  http://metadb.riken.jp/0008079IC57BL6ICRSJLTgLckcreI57JxmTraf3tm1RbrTraf3tm1RbrTraf3tm1RbrTgLckcreI57Jxm
• increased marginal zone B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Tnfsf13b<tm1Msc>/Tnfsf13b<tm1Msc>,Traf2<tm1Rbr>/Traf2<tm1Rbr>
  http://metadb.riken.jp/0008181I129P2OlaHsd129S2SvPasC57BL6Cd19tm1creCgnCd19Tnfsf13btm1MscTnfsf13btm1MscTraf2tm1RbrTraf2tm1RbrTraf2tm1RbrCd19tm1creCgnCd19Tnfsf13btm1Msc
• absent marginal zone B cells_Tnfsf13b<tm1Msc>/Tnfsf13b<tm1Msc>,Traf2<tm1Rbr>/Traf2<tm1Rbr>
  http://metadb.riken.jp/0008183I129S2SvPasC57BL6Tnfsf13btm1MscTnfsf13btm1MscTraf2tm1RbrTraf2tm1RbrTnfsf13btm1MscTraf2tm1Rbr
• increased follicular B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Traf2<tm1Rbr>/Traf2<tm1Rbr>
  http://metadb.riken.jp/0008173I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Traf2tm1RbrTraf2tm1RbrCd19Traf2tm1RbrCd19tm1creCgn
• abnormal T cell physiology_Tg(Lck-cre)I57Jxm/?,Traf3<tm1Rbr>/Traf3<tm1Rbr>
  http://metadb.riken.jp/0002444IC57BL6ICRSJLTgLckcreI57JxmTraf3tm1RbrTraf3tm1RbrTraf3tm1RbrTgLckcreI57Jxm
• lymph node hyperplasia_Cd19<tm1(cre)Cgn>/Cd19<+>,Traf3<tm1Rbr>/Traf3<tm1Rbr>
  http://metadb.riken.jp/0008102I129P2OlaHsdC57BL6SJLCd19tm1creCgnCd19Traf3tm1RbrTraf3tm1RbrTraf3tm1RbrCd19tm1creCgnCd19
• absent follicular B cells_Tg(Lck-cre)I57Jxm/?,Traf2<tm1Rbr>/Traf2<tm1Rbr>
  http://metadb.riken.jp/0008175IC57BL6ICRTgLckcreI57JxmTraf2tm1RbrTraf2tm1RbrTgLckcreI57JxmTraf2tm1Rbr
• decreased mature B cell number_Tnfsf13b<tm1Msc>/Tnfsf13b<tm1Msc>,Traf2<tm1Rbr>/Traf2<tm1Rbr>
  http://metadb.riken.jp/0008211I129S2SvPasC57BL6Tnfsf13btm1MscTnfsf13btm1MscTraf2tm1RbrTraf2tm1RbrTnfsf13btm1MscTraf2tm1Rbr
• increased marginal zone B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Traf2<tm1Rbr>/Traf2<tm1Rbr>
  http://metadb.riken.jp/0008181I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Traf2tm1RbrTraf2tm1RbrCd19Traf2tm1RbrCd19tm1creCgn
• increased follicular B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Traf3<tm1Rbr>/Traf3<tm1Rbr>
  http://metadb.riken.jp/0008173I129P2OlaHsdC57BL6SJLCd19tm1creCgnCd19Traf3tm1RbrTraf3tm1RbrTraf3tm1RbrCd19tm1creCgnCd19
• decreased mature B cell number_Tg(Lck-cre)I57Jxm/?,Traf2<tm1Rbr>/Traf2<tm1Rbr>
  http://metadb.riken.jp/0008211IC57BL6ICRTgLckcreI57JxmTraf2tm1RbrTraf2tm1RbrTgLckcreI57JxmTraf2tm1Rbr
• lymph node hyperplasia_Cd19<tm1(cre)Cgn>/Cd19<+>,Traf2<tm1Rbr>/Traf2<tm1Rbr>
  http://metadb.riken.jp/0008102I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Traf2tm1RbrTraf2tm1RbrCd19Traf2tm1RbrCd19tm1creCgn
• increased marginal zone B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Traf2<tm1Rbr>/Traf2<tm1Rbr>,Traf3<tm1Rbr>/Traf3<tm1Rbr>
  http://metadb.riken.jp/0008181I129P2OlaHsdC57BL6SJLCd19tm1creCgnCd19Traf2tm1RbrTraf2tm1RbrTraf3tm1RbrTraf3tm1RbrCd19Traf2tm1RbrCd19tm1creCgnTraf3tm1Rbr
• absent marginal zone B cells_Tg(Lck-cre)I57Jxm/?,Traf2<tm1Rbr>/Traf2<tm1Rbr>
  http://metadb.riken.jp/0008183IC57BL6ICRTgLckcreI57JxmTraf2tm1RbrTraf2tm1RbrTgLckcreI57JxmTraf2tm1Rbr
• abnormal B cell physiology_Cd19<tm1(cre)Cgn>/Cd19<+>,Traf2<tm1Rbr>/Traf2<tm1Rbr>,Traf3<tm1Rbr>/Traf3<tm1Rbr>
  http://metadb.riken.jp/0002459I129P2OlaHsdC57BL6SJLCd19tm1creCgnCd19Traf2tm1RbrTraf2tm1RbrTraf3tm1RbrTraf3tm1RbrCd19Traf2tm1RbrCd19tm1creCgnTraf3tm1Rbr
• absent follicular B cells_Tnfsf13b<tm1Msc>/Tnfsf13b<tm1Msc>,Traf2<tm1Rbr>/Traf2<tm1Rbr>
  http://metadb.riken.jp/0008175I129S2SvPasC57BL6Tnfsf13btm1MscTnfsf13btm1MscTraf2tm1RbrTraf2tm1RbrTnfsf13btm1MscTraf2tm1Rbr
• increased follicular B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Tnfsf13b<tm1Msc>/Tnfsf13b<tm1Msc>,Traf2<tm1Rbr>/Traf2<tm1Rbr>
  http://metadb.riken.jp/0008173I129P2OlaHsd129S2SvPasC57BL6Cd19tm1creCgnCd19Tnfsf13btm1MscTnfsf13btm1MscTraf2tm1RbrTraf2tm1RbrTraf2tm1RbrCd19tm1creCgnCd19Tnfsf13btm1Msc
• abnormal B cell physiology_Cd19<tm1(cre)Cgn>/Cd19<+>,Traf3<tm1Rbr>/Traf3<tm1Rbr>
  http://metadb.riken.jp/0002459I129P2OlaHsdC57BL6SJLCd19tm1creCgnCd19Traf3tm1RbrTraf3tm1RbrTraf3tm1RbrCd19tm1creCgnCd19
• abnormal B cell physiology_Cd19<tm1(cre)Cgn>/Cd19<+>,Traf2<tm1Rbr>/Traf2<tm1Rbr>
  http://metadb.riken.jp/0002459I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Traf2tm1RbrTraf2tm1RbrCd19Traf2tm1RbrCd19tm1creCgn
• decreased CD4-positive, alpha beta T cell number_Tg(Lck-cre)I57Jxm/?,Traf3<tm1Rbr>/Traf3<tm1Rbr>
  http://metadb.riken.jp/0008075IC57BL6ICRSJLTgLckcreI57JxmTraf3tm1RbrTraf3tm1RbrTraf3tm1RbrTgLckcreI57Jxm
• increased marginal zone B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Traf3<tm1Rbr>/Traf3<tm1Rbr>
  http://metadb.riken.jp/0008181I129P2OlaHsdC57BL6SJLCd19tm1creCgnCd19Traf3tm1RbrTraf3tm1RbrTraf3tm1RbrCd19tm1creCgnCd19

class

http://purl.org/net/cito/citesAsAuthority

• Traf3<tm1.1Rbr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3777325
• Traf3<tm1Rbr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3777324

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD09228
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD09228