Yutaka. Shigeyama, et.al., Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice., Molecular and cellular biology, 2008, 28

http://rdf.ncbi.nlm.nih.gov/pubmed/18316403

Yutaka. Shigeyama, et.al., Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice., Molecular and cellular biology, 2008, 28

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tsc2<tm1.1Kido>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3795271
• Tsc2<tm1Kido>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3795269

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased circulating glucose level_Tg(Ins2-cre)23Herr/0,Tsc2<tm1Kido>/Tsc2<tm1Kido>
  http://metadb.riken.jp/0005559I129S4SvJaeC57BL6C57BL6JCBAJTgIns2cre23Herr0Tsc2tm1KidoTsc2tm1KidoTsc2tm1KidoTgIns2cre23Herr
• improved glucose tolerance_Tg(Ins2-cre)23Herr/0,Tsc2<tm1Kido>/Tsc2<tm1Kido>
  http://metadb.riken.jp/0005292I129S4SvJaeC57BL6C57BL6JCBAJTgIns2cre23Herr0Tsc2tm1KidoTsc2tm1KidoTsc2tm1KidoTgIns2cre23Herr
• increased insulin sensitivity_Tg(Ins2-cre)23Herr/0,Tsc2<tm1Kido>/Tsc2<tm1Kido>
  http://metadb.riken.jp/0002891I129S4SvJaeC57BL6C57BL6JCBAJTgIns2cre23Herr0Tsc2tm1KidoTsc2tm1KidoTsc2tm1KidoTgIns2cre23Herr
• hypoglycemia_Tg(Ins2-cre)23Herr/0,Tsc2<tm1Kido>/Tsc2<tm1Kido>
  http://metadb.riken.jp/0000189I129S4SvJaeC57BL6C57BL6JCBAJTgIns2cre23Herr0Tsc2tm1KidoTsc2tm1KidoTsc2tm1KidoTgIns2cre23Herr
• increased kidney tumor incidence_Tsc2<tm1.1Kido>/Tsc2<+>
  http://metadb.riken.jp/0010294I129S4SvJaeC57BL6Tsc2tm11KidoTsc2Tsc2tm11KidoTsc2
• abnormal pancreatic islet morphology_Tg(Ins2-cre)23Herr/0,Tsc2<tm1Kido>/Tsc2<tm1Kido>
  http://metadb.riken.jp/0005215I129S4SvJaeC57BL6C57BL6JCBAJTgIns2cre23Herr0Tsc2tm1KidoTsc2tm1KidoTsc2tm1KidoTgIns2cre23Herr
• decreased circulating insulin level_Tg(Ins2-cre)23Herr/0,Tsc2<tm1Kido>/Tsc2<tm1Kido>
  http://metadb.riken.jp/0002727I129S4SvJaeC57BL6C57BL6JCBAJTgIns2cre23Herr0Tsc2tm1KidoTsc2tm1KidoTsc2tm1KidoTgIns2cre23Herr
• pancreatic islet hyperplasia_Tg(Ins2-cre)23Herr/0,Tsc2<tm1Kido>/Tsc2<tm1Kido>
  http://metadb.riken.jp/0005491I129S4SvJaeC57BL6C57BL6JCBAJTgIns2cre23Herr0Tsc2tm1KidoTsc2tm1KidoTsc2tm1KidoTgIns2cre23Herr
• decreased pancreatic beta cell number_Tg(Ins2-cre)23Herr/0,Tsc2<tm1Kido>/Tsc2<tm1Kido>
  http://metadb.riken.jp/0003339I129S4SvJaeC57BL6C57BL6JCBAJTgIns2cre23Herr0Tsc2tm1KidoTsc2tm1KidoTsc2tm1KidoTgIns2cre23Herr
• increased pancreatic beta cell mass_Tg(Ins2-cre)23Herr/0,Tsc2<tm1Kido>/Tsc2<tm1Kido>
  http://metadb.riken.jp/0009113I129S4SvJaeC57BL6C57BL6JCBAJTgIns2cre23Herr0Tsc2tm1KidoTsc2tm1KidoTsc2tm1KidoTgIns2cre23Herr
• no abnormal phenotype detected_Tsc2<tm1Kido>/Tsc2<tm1Kido>
  http://metadb.riken.jp/0002169I129S4SvJaeC57BL6Tsc2tm1KidoTsc2tm1KidoTsc2tm1Kido
• increased circulating insulin level_Tg(Ins2-cre)23Herr/0,Tsc2<tm1Kido>/Tsc2<tm1Kido>
  http://metadb.riken.jp/0002079I129S4SvJaeC57BL6C57BL6JCBAJTgIns2cre23Herr0Tsc2tm1KidoTsc2tm1KidoTsc2tm1KidoTgIns2cre23Herr
• decreased body weight_Tg(Ins2-cre)23Herr/0,Tsc2<tm1Kido>/Tsc2<tm1Kido>
  http://metadb.riken.jp/0001262I129S4SvJaeC57BL6C57BL6JCBAJTgIns2cre23Herr0Tsc2tm1KidoTsc2tm1KidoTsc2tm1KidoTgIns2cre23Herr

class

http://purl.org/net/cito/citesAsAuthority

• Tsc2<tm1.1Kido>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3795271
• Tsc2<tm1Kido>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3795269