Hanna. Sagelius, et.al., Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease., Journal of cell science, 2008, 121

http://rdf.ncbi.nlm.nih.gov/pubmed/18334552

Hanna. Sagelius, et.al., Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease., Journal of cell science, 2008, 121

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-LMNA,-EGFP)SF1-04Maer
  http://metadb.riken.jp/db/mgi_rdf/MGI:3834665
• Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer
  http://metadb.riken.jp/db/mgi_rdf/MGI:3834666

class

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-LMNA,-EGFP)SF1-04Maer
  http://metadb.riken.jp/db/mgi_rdf/MGI:3834665
• Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer
  http://metadb.riken.jp/db/mgi_rdf/MGI:3834666

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hyperkeratosis_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0001242IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer
• sparse hair_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0000416IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer
• epidermal hyperplasia_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0001222IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer
• stomach hypoplasia_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0010788IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer
• abnormal hypodermis morphology_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0003705IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer
• skin fibrosis_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0009932IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer
• skin lesions_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0001212IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer
• abnormal incisor morphology_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0005358IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer
• premature death_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0002083IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer
• skin inflammation_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0004947IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer
• sebaceous gland hypoplasia_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0013193IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer
• abnormal dermal layer morphology_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0001243IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer
• enlarged sebaceous gland_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0000652IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer
• decreased body weight_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0001262IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer
• abnormal epidermis stratum granulosum morphology_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0001239IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer
• sebaceous gland hyperplasia_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0009794IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer
• abnormal mouth morphology_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0000452IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer
• abnormal sebocyte differentiation_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0013376IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer
• abnormal hair follicle morphology_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0
  http://metadb.riken.jp/0000377IFVBNTgKRT5tTA1216Glk0TgtetOLMNAG608GEGFPVF107Maer0TgKRT5tTA1216GlkTgtetOLMNAG608GEGFPVF107Maer