Sarah K. Knutson, et.al., Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks., The EMBO journal, 2008, 27

http://rdf.ncbi.nlm.nih.gov/pubmed/18354499

Sarah K. Knutson, et.al., Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks., The EMBO journal, 2008, 27

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• enlarged liver_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000599I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh
• hepatic steatosis_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002628I129S6SvEvTacC57BL6CBAHdac3tm1SwhHdac3tm11SwhTgMx1cre1Cgn0Hdac3tm1SwhHdac3tm11SwhTgMx1cre1Cgn
• abnormal hepatocyte morphology_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000607I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh
• increased hepatocyte proliferation_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003893I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh
• hepatic steatosis_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002628I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh
• increased circulating alanine transaminase level_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002941I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh
• increased circulating triglyceride level_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0001552I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh
• increased circulating cholesterol level_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005178I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh
• enlarged liver_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000599I129S6SvEvTacC57BL6CBAHdac3tm1SwhHdac3tm11SwhTgMx1cre1Cgn0Hdac3tm1SwhHdac3tm11SwhTgMx1cre1Cgn
• decreased glycogen level_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005439I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh
• hypoglycemia_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000189I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh
• increased circulating LDL cholesterol level_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000182I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh
• decreased total body fat amount_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0010025I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh
• increased cholesterol level_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003982I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh
• abnormal glucose homeostasis_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002078I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh
• decreased body size_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0001265I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh
• pale liver_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000603I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh
• decreased glycogen level_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005439I129S6SvEvTacC57BL6CBAHdac3tm1SwhHdac3tm11SwhTgMx1cre1Cgn0Hdac3tm1SwhHdac3tm11SwhTgMx1cre1Cgn
• abnormal hepatocyte morphology_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000607I129S6SvEvTacC57BL6CBAHdac3tm1SwhHdac3tm11SwhTgMx1cre1Cgn0Hdac3tm1SwhHdac3tm11SwhTgMx1cre1Cgn
• increased liver triglyceride level_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0009355I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh
• decreased circulating glucagon level_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002696I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh
• increased liver weight_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002981I129S6SvEvTacC57BL6CBAHdac3tm1SwhHdac3tm11SwhTgMx1cre1Cgn0Hdac3tm1SwhHdac3tm11SwhTgMx1cre1Cgn
• decreased circulating insulin level_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002727I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh
• increased liver weight_Hdac3<tm1Swh>/Hdac3<tm1.1Swh>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002981I129S6SvEvTacC57BL6DBAHdac3tm1SwhHdac3tm11SwhTgAlbcre21Mgn0Hdac3tm11SwhTgAlbcre21MgnHdac3tm1Swh