Yaroslava. Ruzankina, et.al., Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss., Cell stem cell, 2007, 1

http://rdf.ncbi.nlm.nih.gov/pubmed/18371340

Yaroslava. Ruzankina, et.al., Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss., Cell stem cell, 2007, 1

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(UBC-cre/ERT2)1Ejb
  http://metadb.riken.jp/db/mgi_rdf/MGI:3707333

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal hair follicle development_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0003704I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• abnormal hair shaft morphology_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0003809I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• abnormal hair cycle_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0000427I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• osteoporosis_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0000066I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• decreased subcutaneous adipose tissue amount_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0008844I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• thick skin_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0001200I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• cardiac fibrosis_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0003141I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• sebaceous gland hyperplasia_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0009794I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• decreased hair follicle number_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0000379I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• abnormal coat/hair pigmentation_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0002075I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• renal fibrosis_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0003985I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• alopecia_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0000414I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• renal glomerulus atrophy_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0011363I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• abnormal intestinal epithelium morphology_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0000488I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• delayed hair regrowth_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0000423I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• decreased thymocyte number_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0000715I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• abnormal hair follicle morphology_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0000377I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• kidney inflammation_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0001859I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• abnormal liver morphology_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0000598I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• kidney atrophy_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0004970I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• abnormal thymus involution_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0001824I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• decreased body weight_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0001262I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• abnormal trabecular bone morphology_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0000130I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• decreased cell proliferation_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0000352I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• renal tubule atrophy_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0011346I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• abnormal hair growth_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0002073I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• kyphosis_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0000160I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal
• decreased compact bone thickness_Atr<tm1Bal>/Atr<tm2Bal>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0000135I129SSvEv129S2SvPasC57BL6Atrtm1BalAtrtm2BalTgUBCcreERT21Ejb0TgUBCcreERT21EjbAtrtm1BalAtrtm2Bal

class

http://purl.org/net/cito/citesAsAuthority

• Tg(UBC-cre/ERT2)1Ejb
  http://metadb.riken.jp/db/mgi_rdf/MGI:3707333