Xiuqian. Mu, et.al., Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2., Proceedings of the National Academy of Sciences of the United States of America, 2008, 105

http://rdf.ncbi.nlm.nih.gov/pubmed/18460603

Xiuqian. Mu, et.al., Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2., Proceedings of the National Academy of Sciences of the United States of America, 2008, 105

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Isl1<tm1.2Whk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3837978
• Isl1<tm1.1Whk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3837972

class

http://purl.org/net/cito/citesAsAuthority

• Isl1<tm1.2Whk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3837978
• Isl1<tm1.1Whk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3837972

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• microphthalmia_Isl1<tm1.1Whk>/Isl1<tm1.1Whk>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0001297I129S4SvJaeSor129S6SvEvTacC57BL6DBA2Isl1tm11WhkIsl1tm11WhkTgSix3cre69Frty0Isl1tm11WhkTgSix3cre69Frty
• abnormal optic nerve morphology_Isl1<tm1.1Whk>/Isl1<tm1.1Whk>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0001330I129S4SvJaeSor129S6SvEvTacC57BL6DBA2Isl1tm11WhkIsl1tm11WhkTgSix3cre69Frty0Isl1tm11WhkTgSix3cre69Frty
• optic nerve degeneration_Isl1<tm1.1Whk>/Isl1<tm1.1Whk>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0006219I129S4SvJaeSor129S6SvEvTacC57BL6DBA2Isl1tm11WhkIsl1tm11WhkTgSix3cre69Frty0Isl1tm11WhkTgSix3cre69Frty
• thin retinal inner nuclear layer_Isl1<tm1.1Whk>/Isl1<tm1.1Whk>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0008511I129S4SvJaeSor129S6SvEvTacC57BL6DBA2Isl1tm11WhkIsl1tm11WhkTgSix3cre69Frty0Isl1tm11WhkTgSix3cre69Frty
• increased retinal apoptosis_Isl1<tm1.1Whk>/Isl1<tm1.1Whk>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0030005I129S4SvJaeSor129S6SvEvTacC57BL6DBA2Isl1tm11WhkIsl1tm11WhkTgSix3cre69Frty0Isl1tm11WhkTgSix3cre69Frty
• abnormal retinal outer plexiform layer morphology_Isl1<tm1.1Whk>/Isl1<tm1.1Whk>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0003732I129S4SvJaeSor129S6SvEvTacC57BL6DBA2Isl1tm11WhkIsl1tm11WhkTgSix3cre69Frty0Isl1tm11WhkTgSix3cre69Frty
• decreased retinal ganglion cell number_Isl1<tm1.1Whk>/Isl1<tm1.1Whk>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0006309I129S4SvJaeSor129S6SvEvTacC57BL6DBA2Isl1tm11WhkIsl1tm11WhkTgSix3cre69Frty0Isl1tm11WhkTgSix3cre69Frty
• thin retinal inner plexiform layer_Isl1<tm1.1Whk>/Isl1<tm1.1Whk>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0008513I129S4SvJaeSor129S6SvEvTacC57BL6DBA2Isl1tm11WhkIsl1tm11WhkTgSix3cre69Frty0Isl1tm11WhkTgSix3cre69Frty
• decreased amacrine cell number_Isl1<tm1.1Whk>/Isl1<tm1.1Whk>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0008106I129S4SvJaeSor129S6SvEvTacC57BL6DBA2Isl1tm11WhkIsl1tm11WhkTgSix3cre69Frty0Isl1tm11WhkTgSix3cre69Frty
• preweaning lethality, complete penetrance_Isl1<tm1.2Whk>/Isl1<tm1.2Whk>
  http://metadb.riken.jp/0011100I129S4SvJaeSor129S6SvEvTacC57BL6NcrIsl1tm12WhkIsl1tm12WhkIsl1tm12Whk
• abnormal retinal bipolar cell morphology_Isl1<tm1.1Whk>/Isl1<tm1.1Whk>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0006073I129S4SvJaeSor129S6SvEvTacC57BL6DBA2Isl1tm11WhkIsl1tm11WhkTgSix3cre69Frty0Isl1tm11WhkTgSix3cre69Frty
• abnormal retinal ganglion cell morphology_Isl1<tm1.1Whk>/Isl1<tm1.1Whk>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0008056I129S4SvJaeSor129S6SvEvTacC57BL6DBA2Isl1tm11WhkIsl1tm11WhkTgSix3cre69Frty0Isl1tm11WhkTgSix3cre69Frty

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD00180
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00180