Hasan O. Akman, et.al., Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance., Human molecular genetics, 2008, 17

http://rdf.ncbi.nlm.nih.gov/pubmed/18467430

Hasan O. Akman, et.al., Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance., Human molecular genetics, 2008, 17

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tk2<tm1Mihi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3808750

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal mitochondrial ATP synthesis coupled electron transport_Tk2<tm1Mihi>/Tk2<tm1Mihi>
  http://metadb.riken.jp/0010956I129X1SvJC57BL6JTk2tm1MihiTk2tm1MihiTk2tm1Mihi
• abnormal nervous system morphology_Tk2<tm1Mihi>/Tk2<tm1Mihi>
  http://metadb.riken.jp/0003632I129X1SvJC57BL6JTk2tm1MihiTk2tm1MihiTk2tm1Mihi
• abnormal gait_Tk2<tm1Mihi>/Tk2<tm1Mihi>
  http://metadb.riken.jp/0001406I129X1SvJC57BL6JTk2tm1MihiTk2tm1MihiTk2tm1Mihi
• abnormal spinal cord interneuron morphology_Tk2<tm1Mihi>/Tk2<tm1Mihi>
  http://metadb.riken.jp/0004100I129X1SvJC57BL6JTk2tm1MihiTk2tm1MihiTk2tm1Mihi
• tremors_Tk2<tm1Mihi>/Tk2<tm1Mihi>
  http://metadb.riken.jp/0000745I129X1SvJC57BL6JTk2tm1MihiTk2tm1MihiTk2tm1Mihi
• weakness_Tk2<tm1Mihi>/Tk2<tm1Mihi>
  http://metadb.riken.jp/0000746I129X1SvJC57BL6JTk2tm1MihiTk2tm1MihiTk2tm1Mihi
• abnormal astrocyte morphology_Tk2<tm1Mihi>/Tk2<tm1Mihi>
  http://metadb.riken.jp/0002182I129X1SvJC57BL6JTk2tm1MihiTk2tm1MihiTk2tm1Mihi
• decreased mitochondrial DNA content_Tk2<tm1Mihi>/Tk2<tm1Mihi>
  http://metadb.riken.jp/0011639I129X1SvJC57BL6JTk2tm1MihiTk2tm1MihiTk2tm1Mihi
• hypoactivity_Tk2<tm1Mihi>/Tk2<tm1Mihi>
  http://metadb.riken.jp/0001402I129X1SvJC57BL6JTk2tm1MihiTk2tm1MihiTk2tm1Mihi
• postnatal growth retardation_Tk2<tm1Mihi>/Tk2<tm1Mihi>
  http://metadb.riken.jp/0001732I129X1SvJC57BL6JTk2tm1MihiTk2tm1MihiTk2tm1Mihi
• postnatal lethality, complete penetrance_Tk2<tm1Mihi>/Tk2<tm1Mihi>
  http://metadb.riken.jp/0011085I129X1SvJC57BL6JTk2tm1MihiTk2tm1MihiTk2tm1Mihi

class

http://purl.org/net/cito/citesAsAuthority

• Tk2<tm1Mihi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3808750

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD21782
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD21782