Meilin. Wu, et.al., Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice., The Journal of clinical investigation, 2008, 118

http://rdf.ncbi.nlm.nih.gov/pubmed/18483623

Meilin. Wu, et.al., Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice., The Journal of clinical investigation, 2008, 118

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm2(Pax3)Joe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3803568

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal pterygoid process morphology_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0004452I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3GtROSA26Sortm2Pax3JoePax3Pax3tm1creJoe
• open neural tube_Pax3<tm1(cre)Joe>/Pax3<tm1(cre)Joe>
  http://metadb.riken.jp/0000929NSPax3tm1creJoePax3tm1creJoePax3tm1creJoe
• decreased tympanic ring size_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0006020I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3GtROSA26Sortm2Pax3JoePax3Pax3tm1creJoe
• decreased palatal length_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<+>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0003760I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26SorPax3tm1creJoePax3Pax3GtROSA26Sortm2Pax3JoeGtROSA26SorPax3tm1creJoe
• abnormal forelimb morphology_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0000550I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3GtROSA26Sortm2Pax3JoePax3Pax3tm1creJoe
• abnormal eyelid morphology_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0001340I129S1Sv129X1SvJC57BL6CBAGtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoeTgWnt1cre11Rth0GtROSA26Sortm2Pax3JoeTgWnt1cre11Rth
• abnormal craniofacial morphology_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000428I129S1Sv129X1SvJC57BL6CBAGtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoeTgWnt1cre11Rth0GtROSA26Sortm2Pax3JoeTgWnt1cre11Rth
• postnatal lethality_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<tm1(cre)Joe>
  http://metadb.riken.jp/0002082I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3tm1creJoeGtROSA26Sortm2Pax3JoePax3tm1creJoe
• alisphenoid bone hypoplasia_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0004460I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3GtROSA26Sortm2Pax3JoePax3Pax3tm1creJoe
• abnormal diaphragm development_Pax3<tm1(cre)Joe>/Pax3<tm1(cre)Joe>
  http://metadb.riken.jp/0012251NSPax3tm1creJoePax3tm1creJoePax3tm1creJoe
• abnormal craniofacial bone morphology_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0002116I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3GtROSA26Sortm2Pax3JoePax3Pax3tm1creJoe
• postnatal lethality_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0002082I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3GtROSA26Sortm2Pax3JoePax3Pax3tm1creJoe
• cleft palate_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0000111I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3GtROSA26Sortm2Pax3JoePax3Pax3tm1creJoe
• no abnormal phenotype detected_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>
  http://metadb.riken.jp/0002169I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3Joe
• abnormal palate morphology_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0003755I129S1Sv129X1SvJC57BL6CBAGtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoeTgWnt1cre11Rth0GtROSA26Sortm2Pax3JoeTgWnt1cre11Rth
• absent pterygoid process_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0004454I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3GtROSA26Sortm2Pax3JoePax3Pax3tm1creJoe
• abnormal secondary palate development_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0009655I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3GtROSA26Sortm2Pax3JoePax3Pax3tm1creJoe
• abnormal osteoblast differentiation_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0008395I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3GtROSA26Sortm2Pax3JoePax3Pax3tm1creJoe
• exencephaly_Pax3<tm1(cre)Joe>/Pax3<tm1(cre)Joe>
  http://metadb.riken.jp/0000914NSPax3tm1creJoePax3tm1creJoePax3tm1creJoe
• absent eyelids_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0001341I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3GtROSA26Sortm2Pax3JoePax3Pax3tm1creJoe
• postnatal lethality, complete penetrance_Pax3<tm1(cre)Joe>/Pax3<tm1(cre)Joe>
  http://metadb.riken.jp/0011085NSPax3tm1creJoePax3tm1creJoePax3tm1creJoe
• cleft palate_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<+>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000111I129S1Sv129X1SvJC57BL6CBAGtROSA26Sortm2Pax3JoeGtROSA26SorTgWnt1cre11Rth0GtROSA26Sortm2Pax3JoeGtROSA26SorTgWnt1cre11Rth
• abnormal bone ossification_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0008271I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3GtROSA26Sortm2Pax3JoePax3Pax3tm1creJoe
• abnormal eyelid development_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0009651I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3GtROSA26Sortm2Pax3JoePax3Pax3tm1creJoe
• absent alisphenoid bone_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0004458I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3GtROSA26Sortm2Pax3JoePax3Pax3tm1creJoe
• hypaxial muscle hypoplasia_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0003359I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3GtROSA26Sortm2Pax3JoePax3Pax3tm1creJoe
• failure of palatal shelf elevation_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0009886I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3GtROSA26Sortm2Pax3JoePax3Pax3tm1creJoe
• abnormal neural tube morphology_Pax3<tm1(cre)Joe>/Pax3<tm1(cre)Joe>
  http://metadb.riken.jp/0002151NSPax3tm1creJoePax3tm1creJoePax3tm1creJoe
• abnormal hindlimb morphology_Pax3<tm1(cre)Joe>/Pax3<tm1(cre)Joe>
  http://metadb.riken.jp/0000556NSPax3tm1creJoePax3tm1creJoePax3tm1creJoe
• thin diaphragm muscle_Pax3<tm1(cre)Joe>/Pax3<tm1(cre)Joe>
  http://metadb.riken.jp/0000761NSPax3tm1creJoePax3tm1creJoePax3tm1creJoe
• abnormal bone mineralization_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0002896I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3GtROSA26Sortm2Pax3JoePax3Pax3tm1creJoe
• failure of eyelid fusion_Gt(ROSA)26Sor<tm2(Pax3)Joe>/Gt(ROSA)26Sor<tm2(Pax3)Joe>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0009264I129S1Sv129X1SvJC57BL6GtROSA26Sortm2Pax3JoeGtROSA26Sortm2Pax3JoePax3tm1creJoePax3GtROSA26Sortm2Pax3JoePax3Pax3tm1creJoe

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm2(Pax3)Joe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3803568