Youcun. Qian, et.al., Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjögren's syndrome., European journal of immunology, 2008, 38

http://rdf.ncbi.nlm.nih.gov/pubmed/18624351

Youcun. Qian, et.al., Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjögren's syndrome., European journal of immunology, 2008, 38

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased autoantibody level_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0003725C129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• decreased transitional stage B cell number_Tnfsf13b<tm1Msc>/Tnfsf13b<tm1Msc>
  http://metadb.riken.jp/0008190I129S2SvPasTnfsf13btm1MscTnfsf13btm1MscTnfsf13btm1Msc
• decreased B cell number_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>,Tnfsf13b<tm1Msc>/Tnfsf13b<tm1Msc>
  http://metadb.riken.jp/0005017I129129S2SvPasBALBcTraf3ip2tm11LixTraf3ip2tm11LixTnfsf13btm1MscTnfsf13btm1MscTnfsf13btm1MscTraf3ip2tm11Lix
• abnormal gland morphology_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0002163C129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• increased follicular B cell number_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0008173C129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• dry eyes_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0001337C129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• abnormal B cell physiology_Cd40<tm1Kik>/Cd40<tm1Kik>,Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0002459I129129P2OlaHsdBALBcCd40tm1KikCd40tm1KikTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixCd40tm1Kik
• glomerulonephritis_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0002743C129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• abnormal mouth morphology_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0000452C129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• xerostomia_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0000624C129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• increased autoantibody level_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>,Tnfsf13b<tm1Msc>/Tnfsf13b<tm1Msc>
  http://metadb.riken.jp/0003725I129129S2SvPasBALBcTraf3ip2tm11LixTraf3ip2tm11LixTnfsf13btm1MscTnfsf13btm1MscTnfsf13btm1MscTraf3ip2tm11Lix
• increased submandibular gland size_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0009521C129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• increased inflammatory response_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0001846C129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• submandibular gland inflammation_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0008879C129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• blepharitis_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0005251C129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• decreased follicular B cell number_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>,Tnfsf13b<tm1Msc>/Tnfsf13b<tm1Msc>
  http://metadb.riken.jp/0008174I129129S2SvPasBALBcTraf3ip2tm11LixTraf3ip2tm11LixTnfsf13btm1MscTnfsf13btm1MscTnfsf13btm1MscTraf3ip2tm11Lix
• increased marginal zone B cell number_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0008181C129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• increased marginal zone B cell number_Cd40<tm1Kik>/Cd40<tm1Kik>,Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0008181I129129P2OlaHsdBALBcCd40tm1KikCd40tm1KikTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixCd40tm1Kik
• lacrimal gland inflammation_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0008880C129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• premature death_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0002083C129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• decreased B cell number_Tnfsf13b<tm1Msc>/Tnfsf13b<tm1Msc>
  http://metadb.riken.jp/0005017I129S2SvPasTnfsf13btm1MscTnfsf13btm1MscTnfsf13btm1Msc
• parotid gland inflammation_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0013367C129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• increased transitional stage B cell number_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0008189C129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• enlarged submandibular lymph nodes_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0002742C129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• kidney inflammation_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0001859C129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• increased transitional stage B cell number_Cd40<tm1Kik>/Cd40<tm1Kik>,Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0008189I129129P2OlaHsdBALBcCd40tm1KikCd40tm1KikTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixCd40tm1Kik
• increased follicular B cell number_Cd40<tm1Kik>/Cd40<tm1Kik>,Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0008173I129129P2OlaHsdBALBcCd40tm1KikCd40tm1KikTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixCd40tm1Kik
• decreased transitional stage B cell number_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>,Tnfsf13b<tm1Msc>/Tnfsf13b<tm1Msc>
  http://metadb.riken.jp/0008190I129129S2SvPasBALBcTraf3ip2tm11LixTraf3ip2tm11LixTnfsf13btm1MscTnfsf13btm1MscTnfsf13btm1MscTraf3ip2tm11Lix
• decreased mature B cell number_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>,Tnfsf13b<tm1Msc>/Tnfsf13b<tm1Msc>
  http://metadb.riken.jp/0008211I129129S2SvPasBALBcTraf3ip2tm11LixTraf3ip2tm11LixTnfsf13btm1MscTnfsf13btm1MscTnfsf13btm1MscTraf3ip2tm11Lix
• decreased follicular B cell number_Tnfsf13b<tm1Msc>/Tnfsf13b<tm1Msc>
  http://metadb.riken.jp/0008174I129S2SvPasTnfsf13btm1MscTnfsf13btm1MscTnfsf13btm1Msc