Hassan. Nakhai, et.al., Conditional ablation of Notch signaling in pancreatic development., Development (Cambridge, England), 2008, 135

http://rdf.ncbi.nlm.nih.gov/pubmed/18635610

Hassan. Nakhai, et.al., Conditional ablation of Notch signaling in pancreatic development., Development (Cambridge, England), 2008, 135

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Rbpj<tm1Rsch>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3809241
• Rbpj<tm1.1Rsch>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3809244

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal pancreatic alpha cell differentiation_Ptf1a<tm1(cre)Hnak>/Ptf1a<+>,Rbpj<tm1Rsch>/Rbpj<tm1Rsch>
  http://metadb.riken.jp/0009179I129X1SvJPtf1atm1creHnakPtf1aRbpjtm1RschRbpjtm1RschPtf1atm1creHnakPtf1aRbpjtm1Rsch
• abnormal branching involved in pancreas development_Notch1<tm1Agt>/Notch1<tm1Agt>,Notch2<tm1Frad>/Notch2<tm1Frad>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>
  http://metadb.riken.jp/0011934I129BALBcJNotch1tm1AgtNotch1tm1AgtNotch2tm1FradNotch2tm1FradPtf1atm1creHnakPtf1aPtf1atm1creHnakNotch1tm1AgtPtf1aNotch2tm1Frad
• abnormal pancreas development_Ptf1a<tm1(cre)Hnak>/Ptf1a<+>,Rbpj<tm1Rsch>/Rbpj<tm1Rsch>
  http://metadb.riken.jp/0003934I129X1SvJPtf1atm1creHnakPtf1aRbpjtm1RschRbpjtm1RschPtf1atm1creHnakPtf1aRbpjtm1Rsch
• abnormal pancreas development_Notch1<tm1Agt>/Notch1<tm1Agt>,Notch2<tm1Frad>/Notch2<tm1Frad>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>
  http://metadb.riken.jp/0003934I129BALBcJNotch1tm1AgtNotch1tm1AgtNotch2tm1FradNotch2tm1FradPtf1atm1creHnakPtf1aPtf1atm1creHnakNotch1tm1AgtPtf1aNotch2tm1Frad
• abnormal endocrine pancreas morphology_Notch1<tm1Agt>/Notch1<tm1Agt>,Notch2<tm1Frad>/Notch2<tm1Frad>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>
  http://metadb.riken.jp/0009165I129BALBcJNotch1tm1AgtNotch1tm1AgtNotch2tm1FradNotch2tm1FradPtf1atm1creHnakPtf1aPtf1atm1creHnakNotch1tm1AgtPtf1aNotch2tm1Frad
• postnatal lethality, complete penetrance_Ptf1a<tm1(cre)Hnak>/Ptf1a<+>,Rbpj<tm1Rsch>/Rbpj<tm1Rsch>
  http://metadb.riken.jp/0011085I129X1SvJPtf1atm1creHnakPtf1aRbpjtm1RschRbpjtm1RschPtf1atm1creHnakPtf1aRbpjtm1Rsch
• small pancreas_Notch1<tm1Agt>/Notch1<tm1Agt>,Notch2<tm1Frad>/Notch2<tm1Frad>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>
  http://metadb.riken.jp/0004247I129BALBcJNotch1tm1AgtNotch1tm1AgtNotch2tm1FradNotch2tm1FradPtf1atm1creHnakPtf1aPtf1atm1creHnakNotch1tm1AgtPtf1aNotch2tm1Frad
• abnormal pancreatic acinus morphology_Notch1<tm1Agt>/Notch1<tm1Agt>,Notch2<tm1Frad>/Notch2<tm1Frad>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>
  http://metadb.riken.jp/0009145I129BALBcJNotch1tm1AgtNotch1tm1AgtNotch2tm1FradNotch2tm1FradPtf1atm1creHnakPtf1aPtf1atm1creHnakNotch1tm1AgtPtf1aNotch2tm1Frad
• prenatal lethality, complete penetrance_Rbpj<tm1.1Rsch>/Rbpj<tm1.1Rsch>
  http://metadb.riken.jp/0011091I129X1SvJRbpjtm11RschRbpjtm11RschRbpjtm11Rsch
• decreased pancreatic acinar cell number_Ptf1a<tm1(cre)Hnak>/Ptf1a<+>,Rbpj<tm1Rsch>/Rbpj<tm1Rsch>
  http://metadb.riken.jp/0009149I129X1SvJPtf1atm1creHnakPtf1aRbpjtm1RschRbpjtm1RschPtf1atm1creHnakPtf1aRbpjtm1Rsch
• decreased pancreatic islet number_Notch1<tm1Agt>/Notch1<tm1Agt>,Notch2<tm1Frad>/Notch2<tm1Frad>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>
  http://metadb.riken.jp/0009168I129BALBcJNotch1tm1AgtNotch1tm1AgtNotch2tm1FradNotch2tm1FradPtf1atm1creHnakPtf1aPtf1atm1creHnakNotch1tm1AgtPtf1aNotch2tm1Frad
• abnormal pancreas morphology_Ptf1a<tm1(cre)Hnak>/Ptf1a<+>,Rbpj<tm1Rsch>/Rbpj<tm1Rsch>
  http://metadb.riken.jp/0001944I129X1SvJPtf1atm1creHnakPtf1aRbpjtm1RschRbpjtm1RschPtf1atm1creHnakPtf1aRbpjtm1Rsch
• increased pancreatic alpha cell number_Ptf1a<tm1(cre)Hnak>/Ptf1a<+>,Rbpj<tm1Rsch>/Rbpj<tm1Rsch>
  http://metadb.riken.jp/0009176I129X1SvJPtf1atm1creHnakPtf1aRbpjtm1RschRbpjtm1RschPtf1atm1creHnakPtf1aRbpjtm1Rsch
• disorganized pancreatic islets_Ptf1a<tm1(cre)Hnak>/Ptf1a<+>,Rbpj<tm1Rsch>/Rbpj<tm1Rsch>
  http://metadb.riken.jp/0009254I129X1SvJPtf1atm1creHnakPtf1aRbpjtm1RschRbpjtm1RschPtf1atm1creHnakPtf1aRbpjtm1Rsch
• decreased pancreatic islet number_Ptf1a<tm1(cre)Hnak>/Ptf1a<+>,Rbpj<tm1Rsch>/Rbpj<tm1Rsch>
  http://metadb.riken.jp/0009168I129X1SvJPtf1atm1creHnakPtf1aRbpjtm1RschRbpjtm1RschPtf1atm1creHnakPtf1aRbpjtm1Rsch
• postnatal growth retardation_Ptf1a<tm1(cre)Hnak>/Ptf1a<+>,Rbpj<tm1Rsch>/Rbpj<tm1Rsch>
  http://metadb.riken.jp/0001732I129X1SvJPtf1atm1creHnakPtf1aRbpjtm1RschRbpjtm1RschPtf1atm1creHnakPtf1aRbpjtm1Rsch
• abnormal pancreatic bud formation_Notch1<tm1Agt>/Notch1<tm1Agt>,Notch2<tm1Frad>/Notch2<tm1Frad>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>
  http://metadb.riken.jp/0011935I129BALBcJNotch1tm1AgtNotch1tm1AgtNotch2tm1FradNotch2tm1FradPtf1atm1creHnakPtf1aPtf1atm1creHnakNotch1tm1AgtPtf1aNotch2tm1Frad
• abnormal digestion_Ptf1a<tm1(cre)Hnak>/Ptf1a<+>,Rbpj<tm1Rsch>/Rbpj<tm1Rsch>
  http://metadb.riken.jp/0001664I129X1SvJPtf1atm1creHnakPtf1aRbpjtm1RschRbpjtm1RschPtf1atm1creHnakPtf1aRbpjtm1Rsch
• small pancreas_Ptf1a<tm1(cre)Hnak>/Ptf1a<+>,Rbpj<tm1Rsch>/Rbpj<tm1Rsch>
  http://metadb.riken.jp/0004247I129X1SvJPtf1atm1creHnakPtf1aRbpjtm1RschRbpjtm1RschPtf1atm1creHnakPtf1aRbpjtm1Rsch

class

http://purl.org/net/cito/citesAsAuthority

• Rbpj<tm1Rsch>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3809241
• Rbpj<tm1.1Rsch>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3809244

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD13756
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD13756