Lynn. Bedford, et.al., Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 28

http://rdf.ncbi.nlm.nih.gov/pubmed/18701681

Lynn. Bedford, et.al., Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 28

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Psmc1<tm1.1Maye>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3809771
• Psmc1<tm1Maye>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3809769

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• neuron degeneration_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Th<tm1(cre)Te>/Th<+>
  http://metadb.riken.jp/0003224I129X1SvJCD1Psmc1tm1MayePsmc1tm1MayeThtm1creTeThThtm1creTePsmc1tm1MayeTh
• abnormal fear/anxiety-related behavior_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)1Lin/0
  http://metadb.riken.jp/0002065I129C57BL6CD1Psmc1tm1MayePsmc1tm1MayeTgCamk2atTA1Mmay0TgtetOcre1Lin0TgtetOcre1LinPsmc1tm1MayeTgCamk2atTA1Mmay
• alpha-synuclein inclusion body_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)1Lin/0
  http://metadb.riken.jp/0008493I129C57BL6CD1Psmc1tm1MayePsmc1tm1MayeTgCamk2atTA1Mmay0TgtetOcre1Lin0TgtetOcre1LinPsmc1tm1MayeTgCamk2atTA1Mmay
• postnatal lethality_Psmc1<tm1Maye>/Psmc1<tm1.1Maye>,Th<tm1(cre)Te>/Th<+>
  http://metadb.riken.jp/0002082I129X1SvJCD1Psmc1tm1MayePsmc1tm11MayeThtm1creTeThThPsmc1tm11MayeThtm1creTePsmc1tm1Maye
• gliosis_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)1Lin/0
  http://metadb.riken.jp/0002183I129C57BL6CD1Psmc1tm1MayePsmc1tm1MayeTgCamk2atTA1Mmay0TgtetOcre1Lin0TgtetOcre1LinPsmc1tm1MayeTgCamk2atTA1Mmay
• decreased dopamine level_Psmc1<tm1Maye>/Psmc1<tm1.1Maye>,Th<tm1(cre)Te>/Th<+>
  http://metadb.riken.jp/0005643I129X1SvJCD1Psmc1tm1MayePsmc1tm11MayeThtm1creTeThThPsmc1tm11MayeThtm1creTePsmc1tm1Maye
• abnormal noradrenaline level_Psmc1<tm1Maye>/Psmc1<tm1.1Maye>,Th<tm1(cre)Te>/Th<+>
  http://metadb.riken.jp/0003964I129X1SvJCD1Psmc1tm1MayePsmc1tm11MayeThtm1creTeThThPsmc1tm11MayeThtm1creTePsmc1tm1Maye
• neuron degeneration_Psmc1<tm1Maye>/Psmc1<tm1.1Maye>,Th<tm1(cre)Te>/Th<+>
  http://metadb.riken.jp/0003224I129X1SvJCD1Psmc1tm1MayePsmc1tm11MayeThtm1creTeThThPsmc1tm11MayeThtm1creTePsmc1tm1Maye
• thin cerebral cortex_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)1Lin/0
  http://metadb.riken.jp/0006254I129C57BL6CD1Psmc1tm1MayePsmc1tm1MayeTgCamk2atTA1Mmay0TgtetOcre1Lin0TgtetOcre1LinPsmc1tm1MayeTgCamk2atTA1Mmay
• decreased body size_Psmc1<tm1Maye>/Psmc1<tm1.1Maye>,Th<tm1(cre)Te>/Th<+>
  http://metadb.riken.jp/0001265I129X1SvJCD1Psmc1tm1MayePsmc1tm11MayeThtm1creTeThThPsmc1tm11MayeThtm1creTePsmc1tm1Maye
• decreased dopamine level_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Th<tm1(cre)Te>/Th<+>
  http://metadb.riken.jp/0005643I129X1SvJCD1Psmc1tm1MayePsmc1tm1MayeThtm1creTeThThtm1creTePsmc1tm1MayeTh
• increased neuron apoptosis_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)1Lin/0
  http://metadb.riken.jp/0003203I129C57BL6CD1Psmc1tm1MayePsmc1tm1MayeTgCamk2atTA1Mmay0TgtetOcre1Lin0TgtetOcre1LinPsmc1tm1MayeTgCamk2atTA1Mmay
• forebrain atrophy_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)1Lin/0
  http://metadb.riken.jp/0012508I129C57BL6CD1Psmc1tm1MayePsmc1tm1MayeTgCamk2atTA1Mmay0TgtetOcre1Lin0TgtetOcre1LinPsmc1tm1MayeTgCamk2atTA1Mmay
• postnatal lethality, complete penetrance_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Th<tm1(cre)Te>/Th<+>
  http://metadb.riken.jp/0011085I129X1SvJCD1Psmc1tm1MayePsmc1tm1MayeThtm1creTeThThtm1creTePsmc1tm1MayeTh
• prenatal lethality, complete penetrance_Psmc1<tm1.1Maye>/Psmc1<tm1.1Maye>
  http://metadb.riken.jp/0011091I129CD1Psmc1tm11MayePsmc1tm11MayePsmc1tm11Maye
• loss of cortex neurons_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)1Lin/0
  http://metadb.riken.jp/0003241I129C57BL6CD1Psmc1tm1MayePsmc1tm1MayeTgCamk2atTA1Mmay0TgtetOcre1Lin0TgtetOcre1LinPsmc1tm1MayeTgCamk2atTA1Mmay
• neurodegeneration_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)1Lin/0
  http://metadb.riken.jp/0002229I129C57BL6CD1Psmc1tm1MayePsmc1tm1MayeTgCamk2atTA1Mmay0TgtetOcre1Lin0TgtetOcre1LinPsmc1tm1MayeTgCamk2atTA1Mmay
• alpha-synuclein inclusion body_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Th<tm1(cre)Te>/Th<+>
  http://metadb.riken.jp/0008493I129X1SvJCD1Psmc1tm1MayePsmc1tm1MayeThtm1creTeThThtm1creTePsmc1tm1MayeTh
• alpha-synuclein inclusion body_Psmc1<tm1Maye>/Psmc1<tm1.1Maye>,Th<tm1(cre)Te>/Th<+>
  http://metadb.riken.jp/0008493I129X1SvJCD1Psmc1tm1MayePsmc1tm11MayeThtm1creTeThThPsmc1tm11MayeThtm1creTePsmc1tm1Maye
• postnatal growth retardation_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)1Lin/0
  http://metadb.riken.jp/0001732I129C57BL6CD1Psmc1tm1MayePsmc1tm1MayeTgCamk2atTA1Mmay0TgtetOcre1Lin0TgtetOcre1LinPsmc1tm1MayeTgCamk2atTA1Mmay
• premature death_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)1Lin/0
  http://metadb.riken.jp/0002083I129C57BL6CD1Psmc1tm1MayePsmc1tm1MayeTgCamk2atTA1Mmay0TgtetOcre1Lin0TgtetOcre1LinPsmc1tm1MayeTgCamk2atTA1Mmay
• gliosis_Psmc1<tm1Maye>/Psmc1<tm1.1Maye>,Th<tm1(cre)Te>/Th<+>
  http://metadb.riken.jp/0002183I129X1SvJCD1Psmc1tm1MayePsmc1tm11MayeThtm1creTeThThPsmc1tm11MayeThtm1creTePsmc1tm1Maye
• abnormal eating behavior_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)1Lin/0
  http://metadb.riken.jp/0001431I129C57BL6CD1Psmc1tm1MayePsmc1tm1MayeTgCamk2atTA1Mmay0TgtetOcre1Lin0TgtetOcre1LinPsmc1tm1MayeTgCamk2atTA1Mmay
• abnormal noradrenaline level_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Th<tm1(cre)Te>/Th<+>
  http://metadb.riken.jp/0003964I129X1SvJCD1Psmc1tm1MayePsmc1tm1MayeThtm1creTeThThtm1creTePsmc1tm1MayeTh
• abnormal spatial learning_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)1Lin/0
  http://metadb.riken.jp/0001463I129C57BL6CD1Psmc1tm1MayePsmc1tm1MayeTgCamk2atTA1Mmay0TgtetOcre1Lin0TgtetOcre1LinPsmc1tm1MayeTgCamk2atTA1Mmay
• decreased body size_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Th<tm1(cre)Te>/Th<+>
  http://metadb.riken.jp/0001265I129X1SvJCD1Psmc1tm1MayePsmc1tm1MayeThtm1creTeThThtm1creTePsmc1tm1MayeTh
• enlarged brain ventricles_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)1Lin/0
  http://metadb.riken.jp/0011380I129C57BL6CD1Psmc1tm1MayePsmc1tm1MayeTgCamk2atTA1Mmay0TgtetOcre1Lin0TgtetOcre1LinPsmc1tm1MayeTgCamk2atTA1Mmay
• gliosis_Psmc1<tm1Maye>/Psmc1<tm1Maye>,Th<tm1(cre)Te>/Th<+>
  http://metadb.riken.jp/0002183I129X1SvJCD1Psmc1tm1MayePsmc1tm1MayeThtm1creTeThThtm1creTePsmc1tm1MayeTh

class

http://purl.org/net/cito/citesAsAuthority

• Psmc1<tm1.1Maye>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3809771
• Psmc1<tm1Maye>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3809769

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD15258
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD15258