Hua. He, et.al., Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita., Molecular and cellular biology, 2009, 29

http://rdf.ncbi.nlm.nih.gov/pubmed/18936156

Hua. He, et.al., Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita., Molecular and cellular biology, 2009, 29

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Pot1b<tm1.1Schg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3831881
• Pot1b<tm1Schg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3831880

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal blood cell morphology/development_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0002429I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• increased apoptosis_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0006042I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• abnormal erythrocyte morphology_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<tm1Rdp>
  http://metadb.riken.jp/0002447I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTerctm1RdpTerctm1RdpPot1btm11Schg
• anemia_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0001577I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• decreased male germ cell number_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>
  http://metadb.riken.jp/0004901I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgPot1btm11Schg
• abnormal granulocyte morphology_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<tm1Rdp>
  http://metadb.riken.jp/0002441I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTerctm1RdpTerctm1RdpPot1btm11Schg
• abnormal spermatogenesis_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<tm1Rdp>
  http://metadb.riken.jp/0001156I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTerctm1RdpTerctm1RdpPot1btm11Schg
• abnormal male germ cell apoptosis_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>
  http://metadb.riken.jp/0008280I129S6SvEvTacC57BL6Pot1btm11SchgPot1btm11SchgPot1btm11Schg
• small testis_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>
  http://metadb.riken.jp/0001147I129S6SvEvTacC57BL6Pot1btm11SchgPot1btm11SchgPot1btm11Schg
• reduced male fertility_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>
  http://metadb.riken.jp/0001922I129S6SvEvTacC57BL6Pot1btm11SchgPot1btm11SchgPot1btm11Schg
• hyperpigmentation_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0001188I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• decreased hematopoietic stem cell number_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0004810I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• decreased leukocyte cell number_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0000221I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• absent bone marrow cell_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<tm1Rdp>
  http://metadb.riken.jp/0000175I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTerctm1RdpTerctm1RdpPot1btm11Schg
• abnormal crypts of Lieberkuhn morphology_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0000490I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• abnormal spermatogenesis_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>
  http://metadb.riken.jp/0001156I129S6SvEvTacC57BL6Pot1btm11SchgPot1btm11SchgPot1btm11Schg
• abnormal granulocyte morphology_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0002441I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• thrombocytopenia_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0003179I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• abnormal nail morphology_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0000579I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• abnormal intestine morphology_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<tm1Rdp>
  http://metadb.riken.jp/0000477I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTerctm1RdpTerctm1RdpPot1btm11Schg
• abnormal nail morphology_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>
  http://metadb.riken.jp/0000579I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgPot1btm11Schg
• decreased body weight_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0001262I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• decreased granulocyte number_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0000334I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• small testis_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0001147I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• decreased male germ cell number_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0004901I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• impaired hematopoiesis_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0001606I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• abnormal definitive hematopoiesis_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0002123I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• abnormal crypts of Lieberkuhn morphology_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>
  http://metadb.riken.jp/0000490I129S6SvEvTacC57BL6Pot1btm11SchgPot1btm11SchgPot1btm11Schg
• absent bone marrow cell_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0000175I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• abnormal seminiferous tubule morphology_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>
  http://metadb.riken.jp/0002216I129S6SvEvTacC57BL6Pot1btm11SchgPot1btm11SchgPot1btm11Schg
• premature death_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0002083I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• decreased male germ cell number_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<tm1Rdp>
  http://metadb.riken.jp/0004901I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTerctm1RdpTerctm1RdpPot1btm11Schg
• decreased body size_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>
  http://metadb.riken.jp/0001265I129S6SvEvTacC57BL6Pot1btm11SchgPot1btm11SchgPot1btm11Schg
• abnormal spermatogenesis_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0001156I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• pancytopenia_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<tm1Rdp>
  http://metadb.riken.jp/0005152I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTerctm1RdpTerctm1RdpPot1btm11Schg
• decreased body weight_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>
  http://metadb.riken.jp/0001262I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgPot1btm11Schg
• decreased erythrocyte cell number_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<+>
  http://metadb.riken.jp/0002875I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTercPot1btm11SchgTerctm1RdpTerc
• hyperpigmentation_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>
  http://metadb.riken.jp/0001188I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgPot1btm11Schg
• small testis_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>
  http://metadb.riken.jp/0001147I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgPot1btm11Schg
• postnatal lethality, complete penetrance_Pot1b<tm1.1Schg>/Pot1b<tm1.1Schg>,Terc<tm1Rdp>/Terc<tm1Rdp>
  http://metadb.riken.jp/0011085I129Sv129S6SvEvTacC57BL6SJLPot1btm11SchgPot1btm11SchgTerctm1RdpTerctm1RdpTerctm1RdpPot1btm11Schg

class

http://purl.org/net/cito/citesAsAuthority

• Pot1b<tm1.1Schg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3831881
• Pot1b<tm1Schg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3831880

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD24742
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD24742