Victoria. Marsh, et.al., Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation., Nature genetics, 2008, 40

http://rdf.ncbi.nlm.nih.gov/pubmed/19011632

Victoria. Marsh, et.al., Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation., Nature genetics, 2008, 40

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal small intestine morphology_Apc<tm1Tno>/Apc<+>,Pten<tm2Mak>/Pten<tm2Mak>,Tg(Cyp1a1-cre/ERT)1Dwi/0
  http://metadb.riken.jp/0000496I129P2OlaHsd129S4SvJaeC57BL6CBAApctm1TnoApcPtentm2MakPtentm2MakTgCyp1a1creERT1Dwi0Ptentm2MakApctm1TnoApcTgCyp1a1creERT1Dwi
• increased liver weight_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Cyp1a1-cre)1Dwi/0
  http://metadb.riken.jp/0002981I129P2OlaHsdC57BL6CBAPtentm2MakPtentm2MakTgCyp1a1cre1Dwi0Ptentm2MakTgCyp1a1cre1Dwi
• increased intestinal adenocarcinoma incidence_Apc<tm1Tno>/Apc<+>,Pten<tm2Mak>/Pten<tm2Mak>,Tg(Cyp1a1-cre/ERT)1Dwi/0
  http://metadb.riken.jp/0002957I129P2OlaHsd129S4SvJaeC57BL6CBAApctm1TnoApcPtentm2MakPtentm2MakTgCyp1a1creERT1Dwi0Ptentm2MakApctm1TnoApcTgCyp1a1creERT1Dwi
• abnormal behavior_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Cyp1a1-cre)1Dwi/0
  http://metadb.riken.jp/0004924I129P2OlaHsdC57BL6CBAPtentm2MakPtentm2MakTgCyp1a1cre1Dwi0Ptentm2MakTgCyp1a1cre1Dwi
• premature death_Apc<tm1Tno>/Apc<+>,Pten<tm2Mak>/Pten<tm2Mak>,Tg(Cyp1a1-cre/ERT)1Dwi/0
  http://metadb.riken.jp/0002083I129P2OlaHsd129S4SvJaeC57BL6CBAApctm1TnoApcPtentm2MakPtentm2MakTgCyp1a1creERT1Dwi0Ptentm2MakApctm1TnoApcTgCyp1a1creERT1Dwi
• endometrium hyperplasia_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Cyp1a1-cre)1Dwi/0
  http://metadb.riken.jp/0009092I129P2OlaHsdC57BL6CBAPtentm2MakPtentm2MakTgCyp1a1cre1Dwi0Ptentm2MakTgCyp1a1cre1Dwi
• increased lymphoma incidence_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Cyp1a1-cre)1Dwi/0
  http://metadb.riken.jp/0012431I129P2OlaHsdC57BL6CBAPtentm2MakPtentm2MakTgCyp1a1cre1Dwi0Ptentm2MakTgCyp1a1cre1Dwi
• peritoneal inflammation_Apc<tm1Tno>/Apc<+>,Pten<tm2Mak>/Pten<tm2Mak>,Tg(Cyp1a1-cre/ERT)1Dwi/0
  http://metadb.riken.jp/0003303I129P2OlaHsd129S4SvJaeC57BL6CBAApctm1TnoApcPtentm2MakPtentm2MakTgCyp1a1creERT1Dwi0Ptentm2MakApctm1TnoApcTgCyp1a1creERT1Dwi
• ruffled hair_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0000420I129P2OlaHsdC57BL6CBAPtentm2MakPtentm2MakTgVilcreERT223Syr0TgVilcreERT223SyrPtentm2Mak
• hepatic steatosis_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Cyp1a1-cre)1Dwi/0
  http://metadb.riken.jp/0002628I129P2OlaHsdC57BL6CBAPtentm2MakPtentm2MakTgCyp1a1cre1Dwi0Ptentm2MakTgCyp1a1cre1Dwi
• increased hepatocellular carcinoma incidence_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Cyp1a1-cre)1Dwi/0
  http://metadb.riken.jp/0003331I129P2OlaHsdC57BL6CBAPtentm2MakPtentm2MakTgCyp1a1cre1Dwi0Ptentm2MakTgCyp1a1cre1Dwi

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• digestive/alimentary phenotype in RBRC02301
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020389
• abnormal behavior in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020063
• increased hepatocellular carcinoma incidence in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020050
• increased liver weight in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020048
• ruffled hair in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020014
• hepatic steatosis in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020044
• endometrium hyperplasia in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020074
• increased lymphoma incidence in RBRC02301
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020388