Yongliang. Huo, et.al., Humanized Mouse Model of Cooley's Anemia., The Journal of biological chemistry, 2009, 284

http://rdf.ncbi.nlm.nih.gov/pubmed/19098001

Yongliang. Huo, et.al., Humanized Mouse Model of Cooley's Anemia., The Journal of biological chemistry, 2009, 284

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Hbb<tm1.1(HBG1,HBB*)Ryan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3843171

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased liver iron level_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<+>
  http://metadb.riken.jp/0008807IC57BL6JHbbtm11HBG1HBBRyanHbbHbbtm11HBG1HBBRyanHbb
• enlarged spleen_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<+>
  http://metadb.riken.jp/0000691IC57BL6JHbbtm11HBG1HBBRyanHbbHbbtm11HBG1HBBRyanHbb
• perinatal lethality, complete penetrance_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<tm1.1(HBG1,HBB*)Ryan>
  http://metadb.riken.jp/0011089IC57BL6JHbbtm11HBG1HBBRyanHbbtm11HBG1HBBRyanHbbtm11HBG1HBBRyan
• decreased erythrocyte cell number_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<+>
  http://metadb.riken.jp/0002875IC57BL6JHbbtm11HBG1HBBRyanHbbHbbtm11HBG1HBBRyanHbb
• microcytic anemia_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<+>
  http://metadb.riken.jp/0002810IC57BL6JHbbtm11HBG1HBBRyanHbbHbbtm11HBG1HBBRyanHbb
• reticulocytosis_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<+>
  http://metadb.riken.jp/0002640IC57BL6JHbbtm11HBG1HBBRyanHbbHbbtm11HBG1HBBRyanHbb
• decreased mean corpuscular hemoglobin concentration_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<+>
  http://metadb.riken.jp/0005642IC57BL6JHbbtm11HBG1HBBRyanHbbHbbtm11HBG1HBBRyanHbb
• abnormal iron level_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<+>
  http://metadb.riken.jp/0001770IC57BL6JHbbtm11HBG1HBBRyanHbbHbbtm11HBG1HBBRyanHbb
• extramedullary hematopoiesis_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<+>
  http://metadb.riken.jp/0000240IC57BL6JHbbtm11HBG1HBBRyanHbbHbbtm11HBG1HBBRyanHbb
• increased erythroid progenitor cell number_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<+>
  http://metadb.riken.jp/0003135IC57BL6JHbbtm11HBG1HBBRyanHbbHbbtm11HBG1HBBRyanHbb
• decreased mean corpuscular hemoglobin_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<+>
  http://metadb.riken.jp/0005562IC57BL6JHbbtm11HBG1HBBRyanHbbHbbtm11HBG1HBBRyanHbb
• decreased mean corpuscular volume_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<+>
  http://metadb.riken.jp/0002591IC57BL6JHbbtm11HBG1HBBRyanHbbHbbtm11HBG1HBBRyanHbb
• increased hemoglobin concentration distribution width_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<+>
  http://metadb.riken.jp/0008850IC57BL6JHbbtm11HBG1HBBRyanHbbHbbtm11HBG1HBBRyanHbb
• anisopoikilocytosis_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<+>
  http://metadb.riken.jp/0002641IC57BL6JHbbtm11HBG1HBBRyanHbbHbbtm11HBG1HBBRyanHbb
• abnormal spleen morphology_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<+>
  http://metadb.riken.jp/0000689IC57BL6JHbbtm11HBG1HBBRyanHbbHbbtm11HBG1HBBRyanHbb
• increased spleen red pulp amount_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<+>
  http://metadb.riken.jp/0008476IC57BL6JHbbtm11HBG1HBBRyanHbbHbbtm11HBG1HBBRyanHbb
• increased spleen iron level_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<+>
  http://metadb.riken.jp/0008809IC57BL6JHbbtm11HBG1HBBRyanHbbHbbtm11HBG1HBBRyanHbb
• abnormal bone marrow cavity morphology_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<+>
  http://metadb.riken.jp/0000065IC57BL6JHbbtm11HBG1HBBRyanHbbHbbtm11HBG1HBBRyanHbb
• intermingled spleen red and white pulp_Hbb<tm1.1(HBG1,HBB*)Ryan>/Hbb<+>
  http://metadb.riken.jp/0008475IC57BL6JHbbtm11HBG1HBBRyanHbbHbbtm11HBG1HBBRyanHbb

class

http://purl.org/net/cito/citesAsAuthority

• Hbb<tm1.1(HBG1,HBB*)Ryan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3843171