Michael J. Chen, et.al., Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter., Nature, 2009, 457

http://rdf.ncbi.nlm.nih.gov/pubmed/19129762

Michael J. Chen, et.al., Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter., Nature, 2009, 457

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Cdh5-cre)1Spe
  http://metadb.riken.jp/db/mgi_rdf/MGI:3836418

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Cdh5-cre)1Spe
  http://metadb.riken.jp/db/mgi_rdf/MGI:3836418

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• lethality throughout fetal growth and development, incomplete penetrance_Runx1<tm3Spe>/Runx1<tm3Spe>,Tg(Cdh5-cre)1Spe/0
  http://metadb.riken.jp/0011109I129S1SvImJ129S4SvJaeC57BL6Runx1tm3SpeRunx1tm3SpeTgCdh5cre1Spe0TgCdh5cre1SpeRunx1tm3Spe
• abnormal hematopoietic stem cell morphology_Runx1<tm3Spe>/Runx1<tm3Spe>,Tg(Cdh5-cre)1Spe/0
  http://metadb.riken.jp/0004808I129S1SvImJ129S4SvJaeC57BL6Runx1tm3SpeRunx1tm3SpeTgCdh5cre1Spe0TgCdh5cre1SpeRunx1tm3Spe
• increased monocyte cell number_Runx1<tm3Spe>/Runx1<tm3Spe>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0000220I129S4SvJaeRunx1tm3SpeRunx1tm3SpeTgVav1cre1Graf0Runx1tm3SpeTgVav1cre1Graf
• increased hematopoietic stem cell number_Runx1<tm3Spe>/Runx1<tm3Spe>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0004809I129S4SvJaeRunx1tm3SpeRunx1tm3SpeTgVav1cre1Graf0Runx1tm3SpeTgVav1cre1Graf
• decreased B cell number_Runx1<tm3Spe>/Runx1<tm3Spe>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0005017I129S4SvJaeRunx1tm3SpeRunx1tm3SpeTgVav1cre1Graf0Runx1tm3SpeTgVav1cre1Graf
• increased granulocyte number_Runx1<tm3Spe>/Runx1<tm3Spe>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0000322I129S4SvJaeRunx1tm3SpeRunx1tm3SpeTgVav1cre1Graf0Runx1tm3SpeTgVav1cre1Graf
• anemia_Runx1<tm3Spe>/Runx1<tm3Spe>,Tg(Cdh5-cre)1Spe/0
  http://metadb.riken.jp/0001577I129S1SvImJ129S4SvJaeC57BL6Runx1tm3SpeRunx1tm3SpeTgCdh5cre1Spe0TgCdh5cre1SpeRunx1tm3Spe
• decreased hematopoietic stem cell number_Runx1<tm3Spe>/Runx1<tm3Spe>,Tg(Cdh5-cre)1Spe/0
  http://metadb.riken.jp/0004810I129S1SvImJ129S4SvJaeC57BL6Runx1tm3SpeRunx1tm3SpeTgCdh5cre1Spe0TgCdh5cre1SpeRunx1tm3Spe
• decreased lymphocyte cell number_Runx1<tm3Spe>/Runx1<tm3Spe>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0005016I129S4SvJaeRunx1tm3SpeRunx1tm3SpeTgVav1cre1Graf0Runx1tm3SpeTgVav1cre1Graf
• decreased double-positive T cell number_Runx1<tm3Spe>/Runx1<tm3Spe>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0005092I129S4SvJaeRunx1tm3SpeRunx1tm3SpeTgVav1cre1Graf0Runx1tm3SpeTgVav1cre1Graf
• abnormal common myeloid progenitor cell morphology_Runx1<tm3Spe>/Runx1<tm3Spe>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0006410I129S4SvJaeRunx1tm3SpeRunx1tm3SpeTgVav1cre1Graf0Runx1tm3SpeTgVav1cre1Graf
• abnormal platelet morphology_Runx1<tm3Spe>/Runx1<tm3Spe>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0004720I129S4SvJaeRunx1tm3SpeRunx1tm3SpeTgVav1cre1Graf0Runx1tm3SpeTgVav1cre1Graf
• pale liver_Runx1<tm3Spe>/Runx1<tm3Spe>,Tg(Cdh5-cre)1Spe/0
  http://metadb.riken.jp/0000603I129S1SvImJ129S4SvJaeC57BL6Runx1tm3SpeRunx1tm3SpeTgCdh5cre1Spe0TgCdh5cre1SpeRunx1tm3Spe
• decreased thymocyte number_Runx1<tm3Spe>/Runx1<tm3Spe>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0000715I129S4SvJaeRunx1tm3SpeRunx1tm3SpeTgVav1cre1Graf0Runx1tm3SpeTgVav1cre1Graf
• internal hemorrhage_Runx1<tm3Spe>/Runx1<tm3Spe>,Tg(Cdh5-cre)1Spe/0
  http://metadb.riken.jp/0001634I129S1SvImJ129S4SvJaeC57BL6Runx1tm3SpeRunx1tm3SpeTgCdh5cre1Spe0TgCdh5cre1SpeRunx1tm3Spe