Xiao-Hong. Lu, et.al., Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, 29

http://rdf.ncbi.nlm.nih.gov/pubmed/19228951

Xiao-Hong. Lu, et.al., Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, 29

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Slc6a3-PARK2*Q311X)AXwy
  http://metadb.riken.jp/db/mgi_rdf/MGI:3845880
• Tg(Slc6a3-PARK2*Q311X)DXwy
  http://metadb.riken.jp/db/mgi_rdf/MGI:3845881

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Slc6a3-PARK2*Q311X)AXwy
  http://metadb.riken.jp/db/mgi_rdf/MGI:3845880
• Tg(Slc6a3-PARK2*Q311X)DXwy
  http://metadb.riken.jp/db/mgi_rdf/MGI:3845881

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased vertical activity_Tg(Slc6a3-PARK2*Q311X)AXwy/0
  http://metadb.riken.jp/0002757FVBNJTgSlc6a3PARK2Q311XAXwyTgSlc6a3PARK2Q311XAXwy0TgSlc6a3PARK2Q311XAXwy
• loss of dopaminergic neurons_Tg(Slc6a3-PARK2*Q311X)DXwy/0
  http://metadb.riken.jp/0003244FVBNJTgSlc6a3PARK2Q311XDXwyTgSlc6a3PARK2Q311XDXwy0TgSlc6a3PARK2Q311XDXwy
• impaired balance_Tg(Slc6a3-PARK2*Q311X)AXwy/0
  http://metadb.riken.jp/0001525FVBNJTgSlc6a3PARK2Q311XAXwyTgSlc6a3PARK2Q311XAXwy0TgSlc6a3PARK2Q311XAXwy
• abnormal touch/ nociception_Tg(Slc6a3-PARK2*Q311X)AXwy/0
  http://metadb.riken.jp/0001968FVBNJTgSlc6a3PARK2Q311XAXwyTgSlc6a3PARK2Q311XAXwy0TgSlc6a3PARK2Q311XAXwy
• abnormal substantia nigra morphology_Tg(Slc6a3-PARK2*Q311X)AXwy/0
  http://metadb.riken.jp/0000836FVBNJTgSlc6a3PARK2Q311XAXwyTgSlc6a3PARK2Q311XAXwy0TgSlc6a3PARK2Q311XAXwy
• abnormal locomotor activation_Tg(Slc6a3-PARK2*Q311X)AXwy/0
  http://metadb.riken.jp/0003313FVBNJTgSlc6a3PARK2Q311XAXwyTgSlc6a3PARK2Q311XAXwy0TgSlc6a3PARK2Q311XAXwy
• loss of dopaminergic neurons_Tg(Slc6a3-PARK2*Q311X)AXwy/0
  http://metadb.riken.jp/0003244FVBNJTgSlc6a3PARK2Q311XAXwyTgSlc6a3PARK2Q311XAXwy0TgSlc6a3PARK2Q311XAXwy
• hypoactivity_Tg(Slc6a3-PARK2*Q311X)AXwy/0
  http://metadb.riken.jp/0001402FVBNJTgSlc6a3PARK2Q311XAXwyTgSlc6a3PARK2Q311XAXwy0TgSlc6a3PARK2Q311XAXwy
• decreased dopamine level_Tg(Slc6a3-PARK2*Q311X)AXwy/0
  http://metadb.riken.jp/0005643FVBNJTgSlc6a3PARK2Q311XAXwyTgSlc6a3PARK2Q311XAXwy0TgSlc6a3PARK2Q311XAXwy
• hypoactivity_Tg(Slc6a3-PARK2*Q311X)DXwy/0
  http://metadb.riken.jp/0001402FVBNJTgSlc6a3PARK2Q311XDXwyTgSlc6a3PARK2Q311XDXwy0TgSlc6a3PARK2Q311XDXwy
• abnormal touch/ nociception_Tg(Slc6a3-PARK2*Q311X)DXwy/0
  http://metadb.riken.jp/0001968FVBNJTgSlc6a3PARK2Q311XDXwyTgSlc6a3PARK2Q311XDXwy0TgSlc6a3PARK2Q311XDXwy