Tomasz. Loch, et.al., Different extent of cardiac malfunction and resistance to oxidative stress in heterozygous and homozygous manganese-dependent superoxide dismutase-mutant mice., Cardiovascular research, 2009, 82

http://rdf.ncbi.nlm.nih.gov/pubmed/19293248

Tomasz. Loch, et.al., Different extent of cardiac malfunction and resistance to oxidative stress in heterozygous and homozygous manganese-dependent superoxide dismutase-mutant mice., Cardiovascular research, 2009, 82

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Sod2<tm1(tetO-Sod2)Evbo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4818481

class

http://purl.org/net/cito/citesAsAuthority

• Sod2<tm1(tetO-Sod2)Evbo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4818481

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hypoactivity_Sod2<tm1(tetO-Sod2)Evbo>/Sod2<tm1(tetO-Sod2)Evbo>
  http://metadb.riken.jp/0001402I129S4SvJaeC57BL6Sod2tm1tetOSod2EvboSod2tm1tetOSod2EvboSod2tm1tetOSod2Evbo
• increased cardiomyocyte apoptosis_Sod2<tm1(tetO-Sod2)Evbo>/Sod2<tm1(tetO-Sod2)Evbo>
  http://metadb.riken.jp/0003222I129S4SvJaeC57BL6Sod2tm1tetOSod2EvboSod2tm1tetOSod2EvboSod2tm1tetOSod2Evbo
• decreased ventricle muscle contractility_Sod2<tm1(tetO-Sod2)Evbo>/Sod2<+>
  http://metadb.riken.jp/0005598I129S4SvJaeC57BL6Sod2tm1tetOSod2EvboSod2Sod2Sod2tm1tetOSod2Evbo
• increased physiological sensitivity to xenobiotic_Sod2<tm1(tetO-Sod2)Evbo>/Sod2<+>
  http://metadb.riken.jp/0008873I129S4SvJaeC57BL6Sod2tm1tetOSod2EvboSod2Sod2Sod2tm1tetOSod2Evbo
• myocardial necrosis_Sod2<tm1(tetO-Sod2)Evbo>/Sod2<+>
  http://metadb.riken.jp/0006085I129S4SvJaeC57BL6Sod2tm1tetOSod2EvboSod2Sod2Sod2tm1tetOSod2Evbo
• increased cardiomyocyte apoptosis_Sod2<tm1(tetO-Sod2)Evbo>/Sod2<+>
  http://metadb.riken.jp/0003222I129S4SvJaeC57BL6Sod2tm1tetOSod2EvboSod2Sod2Sod2tm1tetOSod2Evbo
• oxidative stress_Sod2<tm1(tetO-Sod2)Evbo>/Sod2<tm1(tetO-Sod2)Evbo>
  http://metadb.riken.jp/0003674I129S4SvJaeC57BL6Sod2tm1tetOSod2EvboSod2tm1tetOSod2EvboSod2tm1tetOSod2Evbo
• postnatal lethality, complete penetrance_Sod2<tm1(tetO-Sod2)Evbo>/Sod2<tm1(tetO-Sod2)Evbo>
  http://metadb.riken.jp/0011085I129S4SvJaeC57BL6Sod2tm1tetOSod2EvboSod2tm1tetOSod2EvboSod2tm1tetOSod2Evbo
• abnormal heart left ventricle morphology_Sod2<tm1(tetO-Sod2)Evbo>/Sod2<+>
  http://metadb.riken.jp/0003921I129S4SvJaeC57BL6Sod2tm1tetOSod2EvboSod2Sod2Sod2tm1tetOSod2Evbo
• enlarged myocardial fiber_Sod2<tm1(tetO-Sod2)Evbo>/Sod2<+>
  http://metadb.riken.jp/0004564I129S4SvJaeC57BL6Sod2tm1tetOSod2EvboSod2Sod2Sod2tm1tetOSod2Evbo
• impaired balance_Sod2<tm1(tetO-Sod2)Evbo>/Sod2<tm1(tetO-Sod2)Evbo>
  http://metadb.riken.jp/0001525I129S4SvJaeC57BL6Sod2tm1tetOSod2EvboSod2tm1tetOSod2EvboSod2tm1tetOSod2Evbo
• decreased body size_Sod2<tm1(tetO-Sod2)Evbo>/Sod2<tm1(tetO-Sod2)Evbo>
  http://metadb.riken.jp/0001265I129S4SvJaeC57BL6Sod2tm1tetOSod2EvboSod2tm1tetOSod2EvboSod2tm1tetOSod2Evbo
• cardiac fibrosis_Sod2<tm1(tetO-Sod2)Evbo>/Sod2<+>
  http://metadb.riken.jp/0003141I129S4SvJaeC57BL6Sod2tm1tetOSod2EvboSod2Sod2Sod2tm1tetOSod2Evbo