Ying. Huang, et.al., Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability., The Journal of experimental medicine, 2009, 206

http://rdf.ncbi.nlm.nih.gov/pubmed/19349461

Ying. Huang, et.al., Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability., The Journal of experimental medicine, 2009, 206

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Dclre1c<tm1Jsek>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3843046

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased double-positive T cell number_Dclre1c<tm1Jsek>/Dclre1c<tm1Jsek>
  http://metadb.riken.jp/0005092I129S1Sv129X1SvJC57BL6Dclre1ctm1JsekDclre1ctm1JsekDclre1ctm1Jsek
• induced chromosome breakage_Dclre1c<tm1Fwa>/Dclre1c<tm1Fwa>
  http://metadb.riken.jp/0004030I129S6SvEvTacDclre1ctm1FwaDclre1ctm1FwaDclre1ctm1Fwa
• increased cellular sensitivity to gamma-irradiation_Dclre1c<tm1Jsek>/Dclre1c<tm1Jsek>
  http://metadb.riken.jp/0002007I129S1Sv129X1SvJC57BL6Dclre1ctm1JsekDclre1ctm1JsekDclre1ctm1Jsek
• decreased CD4-positive, alpha beta T cell number_Dclre1c<tm1Fwa>/Dclre1c<tm1Fwa>
  http://metadb.riken.jp/0008075I129S6SvEvTacDclre1ctm1FwaDclre1ctm1FwaDclre1ctm1Fwa
• decreased CD4-positive, alpha beta T cell number_Dclre1c<tm1Jsek>/Dclre1c<tm1Jsek>
  http://metadb.riken.jp/0008075I129S1Sv129X1SvJC57BL6Dclre1ctm1JsekDclre1ctm1JsekDclre1ctm1Jsek
• increased cellular sensitivity to gamma-irradiation_Dclre1c<tm1Fwa>/Dclre1c<tm1Fwa>
  http://metadb.riken.jp/0002007I129S6SvEvTacDclre1ctm1FwaDclre1ctm1FwaDclre1ctm1Fwa
• increased pro-B cell number_Dclre1c<tm1Jsek>/Dclre1c<tm1Jsek>
  http://metadb.riken.jp/0008186I129S1Sv129X1SvJC57BL6Dclre1ctm1JsekDclre1ctm1JsekDclre1ctm1Jsek
• spleen hypoplasia_Dclre1c<tm1Fwa>/Dclre1c<tm1Fwa>
  http://metadb.riken.jp/0000694I129S6SvEvTacDclre1ctm1FwaDclre1ctm1FwaDclre1ctm1Fwa
• induced chromosome breakage_Dclre1c<tm1Jsek>/Dclre1c<tm1Jsek>
  http://metadb.riken.jp/0004030I129S1Sv129X1SvJC57BL6Dclre1ctm1JsekDclre1ctm1JsekDclre1ctm1Jsek
• absent B cells_Dclre1c<tm1Fwa>/Dclre1c<tm1Fwa>
  http://metadb.riken.jp/0008071I129S6SvEvTacDclre1ctm1FwaDclre1ctm1FwaDclre1ctm1Fwa
• abnormal immunoglobulin heavy chain V(D)J recombination_Dclre1c<tm1Jsek>/Dclre1c<tm1Jsek>
  http://metadb.riken.jp/0008760I129S1Sv129X1SvJC57BL6Dclre1ctm1JsekDclre1ctm1JsekDclre1ctm1Jsek
• decreased CD8-positive, alpha-beta T cell number_Dclre1c<tm1Jsek>/Dclre1c<tm1Jsek>
  http://metadb.riken.jp/0008079I129S1Sv129X1SvJC57BL6Dclre1ctm1JsekDclre1ctm1JsekDclre1ctm1Jsek
• spleen hypoplasia_Dclre1c<tm1Jsek>/Dclre1c<tm1Jsek>
  http://metadb.riken.jp/0000694I129S1Sv129X1SvJC57BL6Dclre1ctm1JsekDclre1ctm1JsekDclre1ctm1Jsek
• decreased thymocyte number_Dclre1c<tm1Fwa>/Dclre1c<tm1Fwa>
  http://metadb.riken.jp/0000715I129S6SvEvTacDclre1ctm1FwaDclre1ctm1FwaDclre1ctm1Fwa
• decreased CD8-positive, alpha-beta T cell number_Dclre1c<tm1Fwa>/Dclre1c<tm1Fwa>
  http://metadb.riken.jp/0008079I129S6SvEvTacDclre1ctm1FwaDclre1ctm1FwaDclre1ctm1Fwa
• decreased double-positive T cell number_Dclre1c<tm1Fwa>/Dclre1c<tm1Fwa>
  http://metadb.riken.jp/0005092I129S6SvEvTacDclre1ctm1FwaDclre1ctm1FwaDclre1ctm1Fwa
• arrested B cell differentiation_Dclre1c<tm1Fwa>/Dclre1c<tm1Fwa>
  http://metadb.riken.jp/0001802I129S6SvEvTacDclre1ctm1FwaDclre1ctm1FwaDclre1ctm1Fwa
• decreased pre-B cell number_Dclre1c<tm1Jsek>/Dclre1c<tm1Jsek>
  http://metadb.riken.jp/0008209I129S1Sv129X1SvJC57BL6Dclre1ctm1JsekDclre1ctm1JsekDclre1ctm1Jsek
• decreased B cell number_Dclre1c<tm1Jsek>/Dclre1c<tm1Jsek>
  http://metadb.riken.jp/0005017I129S1Sv129X1SvJC57BL6Dclre1ctm1JsekDclre1ctm1JsekDclre1ctm1Jsek
• abnormal T cell receptor beta chain V(D)J recombination_Dclre1c<tm1Fwa>/Dclre1c<tm1Fwa>
  http://metadb.riken.jp/0008758I129S6SvEvTacDclre1ctm1FwaDclre1ctm1FwaDclre1ctm1Fwa
• decreased thymocyte number_Dclre1c<tm1Jsek>/Dclre1c<tm1Jsek>
  http://metadb.riken.jp/0000715I129S1Sv129X1SvJC57BL6Dclre1ctm1JsekDclre1ctm1JsekDclre1ctm1Jsek
• abnormal T cell receptor beta chain V(D)J recombination_Dclre1c<tm1Jsek>/Dclre1c<tm1Jsek>
  http://metadb.riken.jp/0008758I129S1Sv129X1SvJC57BL6Dclre1ctm1JsekDclre1ctm1JsekDclre1ctm1Jsek

class

http://purl.org/net/cito/citesAsAuthority

• Dclre1c<tm1Jsek>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3843046