Kelly A. Miller, et.al., Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo., Cancer research, 2009, 69

http://rdf.ncbi.nlm.nih.gov/pubmed/19351816

Kelly A. Miller, et.al., Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo., Cancer research, 2009, 69

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• premature death_Kras<tm4Tyj>/Kras<+>,Pten<tm2.1Ppp>/Pten<tm2.1Ppp>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0002083129CgKrastm4TyjPtentm21PppTgTpocre1ShkKrastm4TyjKrasPtentm21PppPtentm21PppTgTPOcre1Shk0TgTPOcre1ShkPtentm21PppKrastm4TyjKras
• increased thyroxine level_Kras<tm4Tyj>/Kras<+>,Pten<tm2.1Ppp>/Pten<tm2.1Ppp>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0005470129CgKrastm4TyjPtentm21PppTgTpocre1ShkKrastm4TyjKrasPtentm21PppPtentm21PppTgTPOcre1Shk0TgTPOcre1ShkPtentm21PppKrastm4TyjKras
• decreased circulating thyroid-stimulating hormone level_Kras<tm4Tyj>/Kras<+>,Pten<tm2.1Ppp>/Pten<tm2.1Ppp>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0005119129CgKrastm4TyjPtentm21PppTgTpocre1ShkKrastm4TyjKrasPtentm21PppPtentm21PppTgTPOcre1Shk0TgTPOcre1ShkPtentm21PppKrastm4TyjKras
• increased thyroid carcinoma incidence_Kras<tm4Tyj>/Kras<+>,Pten<tm2.1Ppp>/Pten<tm2.1Ppp>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0010346129CgKrastm4TyjPtentm21PppTgTpocre1ShkKrastm4TyjKrasPtentm21PppPtentm21PppTgTPOcre1Shk0TgTPOcre1ShkPtentm21PppKrastm4TyjKras
• enlarged thyroid gland_Kras<tm4Tyj>/Kras<+>,Pten<tm2.1Ppp>/Pten<tm2.1Ppp>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0005355129CgKrastm4TyjPtentm21PppTgTpocre1ShkKrastm4TyjKrasPtentm21PppPtentm21PppTgTPOcre1Shk0TgTPOcre1ShkPtentm21PppKrastm4TyjKras
• increased metastatic potential_Kras<tm4Tyj>/Kras<+>,Pten<tm2.1Ppp>/Pten<tm2.1Ppp>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0001272129CgKrastm4TyjPtentm21PppTgTpocre1ShkKrastm4TyjKrasPtentm21PppPtentm21PppTgTPOcre1Shk0TgTPOcre1ShkPtentm21PppKrastm4TyjKras