Katsuhiko. Tabuchi, et.al., Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, 29

http://rdf.ncbi.nlm.nih.gov/pubmed/19494151

Katsuhiko. Tabuchi, et.al., Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, 29

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ncstn<tm1.1Sud>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3796837
• Ncstn<tm1Sud>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4943563
• Ncstn<tm1.2Sud>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3848925

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• astrocytosis_Ncstn<tm1.1Sud>/Ncstn<tm1.1Sud>,Tg(Camk2a-cre)1Shn/0
  http://metadb.riken.jp/0003354B6CgNcstntm11SudTgCamk2acre1ShnNcstntm11SudNcstntm11SudTgCamk2acre1Shn0TgCamk2acre1ShnNcstntm11Sud
• abnormal spatial learning_Ncstn<tm1.1Sud>/Ncstn<tm1.1Sud>,Tg(Camk2a-cre)1Shn/0
  http://metadb.riken.jp/0001463B6CgNcstntm11SudTgCamk2acre1ShnNcstntm11SudNcstntm11SudTgCamk2acre1Shn0TgCamk2acre1ShnNcstntm11Sud
• increased neuron apoptosis_Ncstn<tm1.1Sud>/Ncstn<tm1.1Sud>,Tg(Camk2a-cre)1Shn/0
  http://metadb.riken.jp/0003203B6CgNcstntm11SudTgCamk2acre1ShnNcstntm11SudNcstntm11SudTgCamk2acre1Shn0TgCamk2acre1ShnNcstntm11Sud
• thin cerebral cortex_Ncstn<tm1.1Sud>/Ncstn<tm1.1Sud>,Tg(Camk2a-cre)1Shn/0
  http://metadb.riken.jp/0006254B6CgNcstntm11SudTgCamk2acre1ShnNcstntm11SudNcstntm11SudTgCamk2acre1Shn0TgCamk2acre1ShnNcstntm11Sud
• abnormal spatial working memory_Ncstn<tm1.1Sud>/Ncstn<tm1.1Sud>,Tg(Camk2a-cre)1Shn/0
  http://metadb.riken.jp/0008428B6CgNcstntm11SudTgCamk2acre1ShnNcstntm11SudNcstntm11SudTgCamk2acre1Shn0TgCamk2acre1ShnNcstntm11Sud
• loss of cortex neurons_Ncstn<tm1.1Sud>/Ncstn<tm1.1Sud>,Tg(Camk2a-cre)1Shn/0
  http://metadb.riken.jp/0003241B6CgNcstntm11SudTgCamk2acre1ShnNcstntm11SudNcstntm11SudTgCamk2acre1Shn0TgCamk2acre1ShnNcstntm11Sud
• embryonic lethality, complete penetrance_Ncstn<tm1.2Sud>/Ncstn<tm1.2Sud>
  http://metadb.riken.jp/0011092I129S1Sv129X1SvJC57BL6SJLNcstntm12SudNcstntm12SudNcstntm12Sud
• impaired contextual conditioning behavior_Ncstn<tm1.1Sud>/Ncstn<tm1.1Sud>,Tg(Camk2a-cre)1Shn/0
  http://metadb.riken.jp/0009454B6CgNcstntm11SudTgCamk2acre1ShnNcstntm11SudNcstntm11SudTgCamk2acre1Shn0TgCamk2acre1ShnNcstntm11Sud
• abnormal dendrite morphology_Ncstn<tm1.1Sud>/Ncstn<tm1.1Sud>,Tg(Camk2a-cre)1Shn/0
  http://metadb.riken.jp/0008143B6CgNcstntm11SudTgCamk2acre1ShnNcstntm11SudNcstntm11SudTgCamk2acre1Shn0TgCamk2acre1ShnNcstntm11Sud
• decreased CNS synapse formation_Ncstn<tm1.1Sud>/Ncstn<tm1.1Sud>,Tg(Camk2a-cre)1Shn/0
  http://metadb.riken.jp/0004998B6CgNcstntm11SudTgCamk2acre1ShnNcstntm11SudNcstntm11SudTgCamk2acre1Shn0TgCamk2acre1ShnNcstntm11Sud
• gliosis_Ncstn<tm1.1Sud>/Ncstn<tm1.1Sud>,Tg(Camk2a-cre)1Shn/0
  http://metadb.riken.jp/0002183B6CgNcstntm11SudTgCamk2acre1ShnNcstntm11SudNcstntm11SudTgCamk2acre1Shn0TgCamk2acre1ShnNcstntm11Sud
• no abnormal phenotype detected_Ncstn<tm1Sud>/Ncstn<tm1Sud>
  http://metadb.riken.jp/0002169I129S1Sv129X1SvJC57BL6JNcstntm1SudNcstntm1SudNcstntm1Sud

class

http://purl.org/net/cito/citesAsAuthority

• Ncstn<tm1.1Sud>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3796837
• Ncstn<tm1Sud>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4943563
• Ncstn<tm1.2Sud>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3848925

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD04795
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD04795