Tomoki. Nakamura, et.al., Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development., Proceedings of the National Academy of Sciences of the United States of America, 2009, 106

http://rdf.ncbi.nlm.nih.gov/pubmed/19541608

Tomoki. Nakamura, et.al., Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development., Proceedings of the National Academy of Sciences of the United States of America, 2009, 106

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ptpn11<tm1Rbns>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3852439
• Ptpn11<tm1.1Rbns>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3852440

class

http://purl.org/net/cito/citesAsAuthority

• Ptpn11<tm1Rbns>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3852439
• Ptpn11<tm1.1Rbns>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3852440

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• small ears_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000018B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
• absent craniofacial bones_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000073B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
• absent mandible_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000087B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
• abnormal nasal bone morphology_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000102B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
• microcephaly_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000433B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
• short snout_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000445B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
他16件を見る
• abnormal mandible morphology_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000458B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
• abnormal tongue morphology_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000762B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
• abnormal eye distance/ position_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0001299B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
• no abnormal phenotype detected_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>
  http://metadb.riken.jp/0002169B6CgPtpn11tm11RbnsPtpn11tm11RbnsPtpn11tm11RbnsPtpn11tm11Rbns
• abnormal nasopharynx morphology_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0002251B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
• persistent truncus arteriosis_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0002633B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
• micrognathia_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0002639B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
• decreased fetal size_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0004200B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
• abnormal nasal capsule morphology_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0004726B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
• absent nasal capsule_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0008384B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
• ventricular septal defect_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0010402B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
• abnormal aortic arch and aortic arch branch attachment_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0010464B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
• common truncal valve_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0010589B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
• lethality throughout fetal growth and development, complete penetrance_Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0011099B6CgPtpn11tm11RbnsTgWnt1cre11RthPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsTgWnt1cre11Rth
• decreased cardiac neural crest cell number_Gt(ROSA)26Sor<tm1Sor>/Gt(ROSA)26Sor<+>,Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0012749B6CgPtpn11tm11RbnsGtROSA26Sortm1SorTgWnt1cre11RthGtROSA26Sortm1SorGtROSA26SorPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsGtROSA26Sortm1SorTgWnt1cre11RthGtROSA26Sor
• impaired cranial neural crest cell differentiation_Gt(ROSA)26Sor<tm1Sor>/Gt(ROSA)26Sor<+>,Ptpn11<tm1.1Rbns>/Ptpn11<tm1.1Rbns>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0012756B6CgPtpn11tm11RbnsGtROSA26Sortm1SorTgWnt1cre11RthGtROSA26Sortm1SorGtROSA26SorPtpn11tm11RbnsPtpn11tm11RbnsTgWnt1cre11Rth0Ptpn11tm11RbnsGtROSA26Sortm1SorTgWnt1cre11RthGtROSA26Sor