Yong. Fan, et.al., Thymus-specific deletion of insulin induces autoimmune diabetes., The EMBO journal, 2009, 28

http://rdf.ncbi.nlm.nih.gov/pubmed/19680229

Yong. Fan, et.al., Thymus-specific deletion of insulin induces autoimmune diabetes., The EMBO journal, 2009, 28

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ins2<tm1Mnt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4361633
• Tg(Aire-cre)1Mnt
  http://metadb.riken.jp/db/mgi_rdf/MGI:4361672
• Ins2<tm1.1Mnt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4361695

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hyperglycemia_Ins1<tm1Jja>/Ins1<tm1Jja>,Ins2<tm1Mnt>/Ins2<tm1Mnt>,Tg(Aire-cre)1Mnt/0
  http://metadb.riken.jp/0001559I129S2SvPas129S4SvJaeSorC57BL6FVBNIns1tm1JjaIns1tm1JjaIns2tm1MntIns2tm1MntTgAirecre1Mnt0Ins2tm1MntIns1tm1JjaTgAirecre1Mnt
• abnormal circulating insulin level_Ins1<tm1Jja>/Ins1<tm1Jja>,Ins2<tm1Mnt>/Ins2<tm1Mnt>,Tg(Aire-cre)1Mnt/0
  http://metadb.riken.jp/0001560I129S2SvPas129S4SvJaeSorC57BL6FVBNIns1tm1JjaIns1tm1JjaIns2tm1MntIns2tm1MntTgAirecre1Mnt0Ins2tm1MntIns1tm1JjaTgAirecre1Mnt
• abnormal immune system physiology_Ins1<tm1Jja>/Ins1<tm1Jja>,Ins2<tm1Mnt>/Ins2<tm1Mnt>,Tg(Aire-cre)1Mnt/0
  http://metadb.riken.jp/0001790I129S2SvPas129S4SvJaeSorC57BL6FVBNIns1tm1JjaIns1tm1JjaIns2tm1MntIns2tm1MntTgAirecre1Mnt0Ins2tm1MntIns1tm1JjaTgAirecre1Mnt
• pancreas inflammation_Ins1<tm1Jja>/Ins1<tm1Jja>,Ins2<tm1Mnt>/Ins2<tm1Mnt>,Tg(Aire-cre)1Mnt/0
  http://metadb.riken.jp/0001869I129S2SvPas129S4SvJaeSorC57BL6FVBNIns1tm1JjaIns1tm1JjaIns2tm1MntIns2tm1MntTgAirecre1Mnt0Ins2tm1MntIns1tm1JjaTgAirecre1Mnt
• abnormal T cell physiology_Ins1<tm1Jja>/Ins1<tm1Jja>,Ins2<tm1Mnt>/Ins2<tm1Mnt>,Tg(Aire-cre)1Mnt/0
  http://metadb.riken.jp/0002444I129S2SvPas129S4SvJaeSorC57BL6FVBNIns1tm1JjaIns1tm1JjaIns2tm1MntIns2tm1MntTgAirecre1Mnt0Ins2tm1MntIns1tm1JjaTgAirecre1Mnt
• increased anti-insulin autoantibody level_Ins1<tm1Jja>/Ins1<tm1Jja>,Ins2<tm1Mnt>/Ins2<tm1Mnt>,Tg(Aire-cre)1Mnt/0
  http://metadb.riken.jp/0002869I129S2SvPas129S4SvJaeSorC57BL6FVBNIns1tm1JjaIns1tm1JjaIns2tm1MntIns2tm1MntTgAirecre1Mnt0Ins2tm1MntIns1tm1JjaTgAirecre1Mnt
他5件を見る
• decreased pancreatic beta cell number_Ins1<tm1Jja>/Ins1<tm1Jja>,Ins2<tm1Mnt>/Ins2<tm1Mnt>,Tg(Aire-cre)1Mnt/0
  http://metadb.riken.jp/0003339I129S2SvPas129S4SvJaeSorC57BL6FVBNIns1tm1JjaIns1tm1JjaIns2tm1MntIns2tm1MntTgAirecre1Mnt0Ins2tm1MntIns1tm1JjaTgAirecre1Mnt
• abnormal pancreatic beta cell physiology_Ins1<tm1Jja>/Ins1<tm1Jja>,Ins2<tm1Mnt>/Ins2<tm1Mnt>,Tg(Aire-cre)1Mnt/0
  http://metadb.riken.jp/0003562I129S2SvPas129S4SvJaeSorC57BL6FVBNIns1tm1JjaIns1tm1JjaIns2tm1MntIns2tm1MntTgAirecre1Mnt0Ins2tm1MntIns1tm1JjaTgAirecre1Mnt
• increased circulating glucose level_Ins1<tm1Jja>/Ins1<tm1Jja>,Ins2<tm1Mnt>/Ins2<tm1Mnt>,Tg(Aire-cre)1Mnt/0
  http://metadb.riken.jp/0005559I129S2SvPas129S4SvJaeSorC57BL6FVBNIns1tm1JjaIns1tm1JjaIns2tm1MntIns2tm1MntTgAirecre1Mnt0Ins2tm1MntIns1tm1JjaTgAirecre1Mnt
• abnormal interferon-gamma secretion_Ins1<tm1Jja>/Ins1<tm1Jja>,Ins2<tm1Mnt>/Ins2<tm1Mnt>,Tg(Aire-cre)1Mnt/0
  http://metadb.riken.jp/0008559I129S2SvPas129S4SvJaeSorC57BL6FVBNIns1tm1JjaIns1tm1JjaIns2tm1MntIns2tm1MntTgAirecre1Mnt0Ins2tm1MntIns1tm1JjaTgAirecre1Mnt
• postnatal lethality, complete penetrance_Ins1<tm1Jja>/Ins1<tm1Jja>,Ins2<tm1.1Mnt>/Ins2<tm1.1Mnt>
  http://metadb.riken.jp/0011085I129S2SvPas129S4SvJaeSorC57BL6FVBNIns1tm1JjaIns1tm1JjaIns2tm11MntIns2tm11MntIns2tm11MntIns1tm1Jja

class

http://purl.org/net/cito/citesAsAuthority

• Ins2<tm1Mnt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4361633
• Tg(Aire-cre)1Mnt
  http://metadb.riken.jp/db/mgi_rdf/MGI:4361672
• Ins2<tm1.1Mnt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4361695