Ashley M. Goss, et.al., Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut., Developmental cell, 2009, 17

http://rdf.ncbi.nlm.nih.gov/pubmed/19686689

Ashley M. Goss, et.al., Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut., Developmental cell, 2009, 17

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Wnt2b<tm1Eem>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4361156
• Wnt2<tm1.1(rtTA)Eem>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4361155
• Wnt2b<tm1.1Eem>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4361157

class

http://purl.org/net/cito/citesAsAuthority

• Wnt2b<tm1Eem>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4361156
• Wnt2<tm1.1(rtTA)Eem>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4361155
• Wnt2b<tm1.1Eem>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4361157

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal lung-associated mesenchyme development_Wnt2<tm1.1(rtTA)Eem>/Wnt2<tm1.1(rtTA)Eem>
  http://metadb.riken.jp/0011142I129X1SvJC57BL6Wnt2tm11rtTAEemWnt2tm11rtTAEemWnt2tm11rtTAEem
• absent lung buds_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0010907I129S1Sv129X1SvJCtnnb1tm2KemCtnnb1tm2KemShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtShhCtnnb1tm2Kem
• decreased mesenchymal cell proliferation involved in lung development_Wnt2<tm1.1(rtTA)Eem>/Wnt2<tm1.1(rtTA)Eem>
  http://metadb.riken.jp/0011148I129X1SvJC57BL6Wnt2tm11rtTAEemWnt2tm11rtTAEemWnt2tm11rtTAEem
• neonatal lethality, incomplete penetrance_Wnt2<tm1.1(rtTA)Eem>/Wnt2<tm1.1(rtTA)Eem>
  http://metadb.riken.jp/0011088I129X1SvJC57BL6Wnt2tm11rtTAEemWnt2tm11rtTAEemWnt2tm11rtTAEem
• pulmonary hypoplasia_Wnt2<tm1.1(rtTA)Eem>/Wnt2<tm1.1(rtTA)Eem>
  http://metadb.riken.jp/0001178I129X1SvJC57BL6Wnt2tm11rtTAEemWnt2tm11rtTAEemWnt2tm11rtTAEem
• abnormal respiratory system physiology_Wnt2<tm1.1(rtTA)Eem>/Wnt2<tm1.1(rtTA)Eem>
  http://metadb.riken.jp/0002133I129X1SvJC57BL6Wnt2tm11rtTAEemWnt2tm11rtTAEemWnt2tm11rtTAEem
• tracheoesophageal fistula_Ctnnb1<tm1Mmt>/Ctnnb1<tm1Mmt>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0003321I129X1SvJCtnnb1tm1MmtCtnnb1tm1MmtShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtShhCtnnb1tm1Mmt
• no abnormal phenotype detected_Wnt2b<tm1.1Eem>/Wnt2b<tm1.1Eem>
  http://metadb.riken.jp/0002169I129X1SvJC57BL6Wnt2btm11EemWnt2btm11EemWnt2btm11Eem
• abnormal lung development_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0001176I129S1Sv129X1SvJCtnnb1tm2KemCtnnb1tm2KemShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtShhCtnnb1tm2Kem
• absent trachea_Wnt2<tm1.1(rtTA)Eem>/Wnt2<tm1.1(rtTA)Eem>,Wnt2b<tm1.1Eem>/Wnt2b<tm1.1Eem>
  http://metadb.riken.jp/0010885I129X1SvJC57BL6Wnt2tm11rtTAEemWnt2tm11rtTAEemWnt2btm11EemWnt2btm11EemWnt2btm11EemWnt2tm11rtTAEem
• absent lungs_Wnt2<tm1.1(rtTA)Eem>/Wnt2<tm1.1(rtTA)Eem>,Wnt2b<tm1.1Eem>/Wnt2b<tm1.1Eem>
  http://metadb.riken.jp/0001181I129X1SvJC57BL6Wnt2tm11rtTAEemWnt2tm11rtTAEemWnt2btm11EemWnt2btm11EemWnt2btm11EemWnt2tm11rtTAEem
• absent lungs_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0001181I129S1Sv129X1SvJCtnnb1tm2KemCtnnb1tm2KemShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtShhCtnnb1tm2Kem
• cyanosis_Wnt2<tm1.1(rtTA)Eem>/Wnt2<tm1.1(rtTA)Eem>
  http://metadb.riken.jp/0001575I129X1SvJC57BL6Wnt2tm11rtTAEemWnt2tm11rtTAEemWnt2tm11rtTAEem
• abnormal lung vasculature morphology_Wnt2<tm1.1(rtTA)Eem>/Wnt2<tm1.1(rtTA)Eem>
  http://metadb.riken.jp/0004007I129X1SvJC57BL6Wnt2tm11rtTAEemWnt2tm11rtTAEemWnt2tm11rtTAEem