Mallika. Ghosh, et.al., Essential role of the RNA-binding protein HuR in progenitor cell survival in mice., The Journal of clinical investigation, 2009, 119

http://rdf.ncbi.nlm.nih.gov/pubmed/19884656

Mallika. Ghosh, et.al., Essential role of the RNA-binding protein HuR in progenitor cell survival in mice., The Journal of clinical investigation, 2009, 119

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Elavl1<tm1.1Thla>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4414854
• Elavl1<tm1Thla>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4414853

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased leukocyte cell number_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000221I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• decreased granulocyte number_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000334I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• premature death_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002083I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• abnormal definitive hematopoiesis_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002123I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• small intestinal villus atrophy_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0014078I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• decreased B cell apoptosis_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008783I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• decreased double-positive T cell number_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0005092I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• spleen hypoplasia_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000694I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• thymus hypoplasia_Elavl1<tm1.1Thla>/Elavl1<+>
  http://metadb.riken.jp/0001823I129S1SvElavl1tm11ThlaElavl1Elavl1Elavl1tm11Thla
• decreased common myeloid progenitor cell number_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008813I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• abnormal colon morphology_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000495I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• intestinal obstruction_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003270I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• decreased bone marrow cell number_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000333I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• increased granulocyte number_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000322I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• increased cellular sensitivity to gamma-irradiation_Elavl1<tm1.1Thla>/Elavl1<+>
  http://metadb.riken.jp/0002007I129S1SvElavl1tm11ThlaElavl1Elavl1Elavl1tm11Thla
• abnormal myeloid leukocyte morphology_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008250I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• abnormal B cell physiology_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002459I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• abnormal intestinal epithelium morphology_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000488I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• decreased cell proliferation_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000352I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• distended stomach_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0009511I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• lymph node hypoplasia_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008101I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• abnormal crypts of Lieberkuhn morphology_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000490I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• cachexia_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0005150I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• abnormal intestinal goblet cell morphology_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003449I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• abnormal intestinal mucosa morphology_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000511I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• spleen hypoplasia_Elavl1<tm1.1Thla>/Elavl1<+>
  http://metadb.riken.jp/0000694I129S1SvElavl1tm11ThlaElavl1Elavl1Elavl1tm11Thla
• decreased bone marrow cell number_Elavl1<tm1.1Thla>/Elavl1<+>
  http://metadb.riken.jp/0000333I129S1SvElavl1tm11ThlaElavl1Elavl1Elavl1tm11Thla
• decreased erythroid progenitor cell number_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008973I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• preweaning lethality, complete penetrance_Elavl1<tm1.1Thla>/Elavl1<tm1.1Thla>
  http://metadb.riken.jp/0011100I129S1SvElavl1tm11ThlaElavl1tm11ThlaElavl1tm11Thla
• increased T cell apoptosis_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0006413I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor
• thymus hypoplasia_Elavl1<tm1Thla>/Elavl1<tm1Thla>,Gt(ROSA)26Sor<tm1(cre/ERT2)Alj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001823I129Elavl1tm1ThlaElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26SorElavl1tm1ThlaGtROSA26Sortm1creERT2AljGtROSA26Sor

class

http://purl.org/net/cito/citesAsAuthority

• Elavl1<tm1.1Thla>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4414854
• Elavl1<tm1Thla>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4414853