Elizabeth A. Morgan, et.al., Dissection of platelet and myeloid cell defects by conditional targeting of the beta3-integrin subunit., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010, 24

http://rdf.ncbi.nlm.nih.gov/pubmed/19933310

Elizabeth A. Morgan, et.al., Dissection of platelet and myeloid cell defects by conditional targeting of the beta3-integrin subunit., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010, 24

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Itgb3<tm1.1Wlbcr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5688572

class

http://purl.org/net/cito/citesAsAuthority

• Itgb3<tm1.1Wlbcr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5688572

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• postnatal lethality, incomplete penetrance_Itgb3<tm1Hyn>/Itgb3<tm1.1Wlbcr>,Tg(Pf4-icre)Q3Rsko/0
  http://metadb.riken.jp/0011086I129S2SvPasC57BL6Itgb3tm1HynItgb3tm11WlbcrTgPf4icreQ3Rsko0TgPf4icreQ3RskoItgb3tm11WlbcrItgb3tm1Hyn
• decreased hemoglobin content_Itgb3<tm1Hyn>/Itgb3<tm1.1Wlbcr>,Tg(Pf4-icre)Q3Rsko/0
  http://metadb.riken.jp/0002874I129S2SvPasC57BL6Itgb3tm1HynItgb3tm11WlbcrTgPf4icreQ3Rsko0TgPf4icreQ3RskoItgb3tm11WlbcrItgb3tm1Hyn
• gastrointestinal hemorrhage_Itgb3<tm1Hyn>/Itgb3<tm1.1Wlbcr>,Tg(Pf4-icre)Q3Rsko/0
  http://metadb.riken.jp/0000465I129S2SvPasC57BL6Itgb3tm1HynItgb3tm11WlbcrTgPf4icreQ3Rsko0TgPf4icreQ3RskoItgb3tm11WlbcrItgb3tm1Hyn
• enlarged spleen_Itgb3<tm1Hyn>/Itgb3<tm1.1Wlbcr>,Tg(Pf4-icre)Q3Rsko/0
  http://metadb.riken.jp/0000691I129S2SvPasC57BL6Itgb3tm1HynItgb3tm11WlbcrTgPf4icreQ3Rsko0TgPf4icreQ3RskoItgb3tm11WlbcrItgb3tm1Hyn
• decreased osteoclast cell number_Itgb3<tm1Hyn>/Itgb3<tm1.1Wlbcr>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0004985I129P2OlaHsd129S2SvPasC57BL6Itgb3tm1HynItgb3tm11WlbcrLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoItgb3tm11WlbcrItgb3tm1Hyn
• abnormal osteoclast morphology_Itgb3<tm1Hyn>/Itgb3<tm1.1Wlbcr>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0004982I129P2OlaHsd129S2SvPasC57BL6Itgb3tm1HynItgb3tm11WlbcrLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoItgb3tm11WlbcrItgb3tm1Hyn
• decreased platelet aggregation_Itgb3<tm1Hyn>/Itgb3<tm1.1Wlbcr>,Tg(Pf4-icre)Q3Rsko/0
  http://metadb.riken.jp/0009549I129S2SvPasC57BL6Itgb3tm1HynItgb3tm11WlbcrTgPf4icreQ3Rsko0TgPf4icreQ3RskoItgb3tm11WlbcrItgb3tm1Hyn
• increased bone mineral density_Itgb3<tm1Hyn>/Itgb3<tm1.1Wlbcr>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0000062I129P2OlaHsd129S2SvPasC57BL6Itgb3tm1HynItgb3tm11WlbcrLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoItgb3tm11WlbcrItgb3tm1Hyn
• abnormal osteoclast differentiation_Itgb3<tm1Hyn>/Itgb3<tm1.1Wlbcr>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008396I129P2OlaHsd129S2SvPasC57BL6Itgb3tm1HynItgb3tm11WlbcrLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoItgb3tm11WlbcrItgb3tm1Hyn
• intracranial hemorrhage_Itgb3<tm1Hyn>/Itgb3<tm1.1Wlbcr>,Tg(Pf4-icre)Q3Rsko/0
  http://metadb.riken.jp/0001915I129S2SvPasC57BL6Itgb3tm1HynItgb3tm11WlbcrTgPf4icreQ3Rsko0TgPf4icreQ3RskoItgb3tm11WlbcrItgb3tm1Hyn
• osteopetrosis_Itgb3<tm1Hyn>/Itgb3<tm1.1Wlbcr>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0000067I129P2OlaHsd129S2SvPasC57BL6Itgb3tm1HynItgb3tm11WlbcrLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoItgb3tm11WlbcrItgb3tm1Hyn
• decreased collagen level_Itgb3<tm1Hyn>/Itgb3<tm1.1Wlbcr>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0020254I129P2OlaHsd129S2SvPasC57BL6Itgb3tm1HynItgb3tm11WlbcrLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoItgb3tm11WlbcrItgb3tm1Hyn
• no abnormal phenotype detected_Itgb3<tm1.1Wlbcr>/Itgb3<tm1.1Wlbcr>
  http://metadb.riken.jp/0002169IC57BL6Itgb3tm11WlbcrItgb3tm11WlbcrItgb3tm11Wlbcr
• abnormal blood coagulation_Itgb3<tm1Hyn>/Itgb3<tm1.1Wlbcr>,Tg(Pf4-icre)Q3Rsko/0
  http://metadb.riken.jp/0002551I129S2SvPasC57BL6Itgb3tm1HynItgb3tm11WlbcrTgPf4icreQ3Rsko0TgPf4icreQ3RskoItgb3tm11WlbcrItgb3tm1Hyn
• altered tumor susceptibility_Itgb3<tm1Hyn>/Itgb3<tm1.1Wlbcr>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0002166I129P2OlaHsd129S2SvPasC57BL6Itgb3tm1HynItgb3tm11WlbcrLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoItgb3tm11WlbcrItgb3tm1Hyn
• abnormal hemostasis_Itgb3<tm1Hyn>/Itgb3<tm1.1Wlbcr>,Tg(Pf4-icre)Q3Rsko/0
  http://metadb.riken.jp/0009676I129S2SvPasC57BL6Itgb3tm1HynItgb3tm11WlbcrTgPf4icreQ3Rsko0TgPf4icreQ3RskoItgb3tm11WlbcrItgb3tm1Hyn
• increased bleeding time_Itgb3<tm1Hyn>/Itgb3<tm1.1Wlbcr>,Tg(Pf4-icre)Q3Rsko/0
  http://metadb.riken.jp/0005606I129S2SvPasC57BL6Itgb3tm1HynItgb3tm11WlbcrTgPf4icreQ3Rsko0TgPf4icreQ3RskoItgb3tm11WlbcrItgb3tm1Hyn
• increased trabecular bone volume_Itgb3<tm1Hyn>/Itgb3<tm1.1Wlbcr>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0010878I129P2OlaHsd129S2SvPasC57BL6Itgb3tm1HynItgb3tm11WlbcrLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoItgb3tm11WlbcrItgb3tm1Hyn
• altered tumor pathology_Itgb3<tm1Hyn>/Itgb3<tm1.1Wlbcr>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0010639I129P2OlaHsd129S2SvPasC57BL6Itgb3tm1HynItgb3tm11WlbcrLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoItgb3tm11WlbcrItgb3tm1Hyn