Norifumi. Takeda, et.al., Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload., The Journal of clinical investigation, 2010, 120

http://rdf.ncbi.nlm.nih.gov/pubmed/20038803

Norifumi. Takeda, et.al., Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload., The Journal of clinical investigation, 2010, 120

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Klf5<tm2.1Rng>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4421792

class

http://purl.org/net/cito/citesAsAuthority

• Klf5<tm2.1Rng>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4421792

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• cardiac hypertrophy_Klf5<tm2.1Rng>/Klf5<tm2.1Rng>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0001625IC57BL6Klf5tm21RngKlf5tm21RngTgPostncre1Sjc0Klf5tm21RngTgPostncre1Sjc
• no abnormal phenotype detected_Klf5<tm2.1Rng>/Klf5<tm2.1Rng>
  http://metadb.riken.jp/0002169IC57BL6Klf5tm21RngKlf5tm21RngKlf5tm21Rng
• decreased response of heart to induced stress_Klf5<tm1Rng>/Klf5<+>
  http://metadb.riken.jp/0004486I129SvKlf5tm1RngKlf5Klf5tm1RngKlf5
• cardiac fibrosis_Klf5<tm1Rng>/Klf5<+>
  http://metadb.riken.jp/0003141I129SvKlf5tm1RngKlf5Klf5tm1RngKlf5
• increased sensitivity to xenobiotic induced morbidity/mortality_Klf5<tm2.1Rng>/Klf5<tm2.1Rng>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0009766IC57BL6Klf5tm21RngKlf5tm21RngTgPostncre1Sjc0Klf5tm21RngTgPostncre1Sjc
• abnormal myocardial fiber physiology_Klf5<tm2.1Rng>/Klf5<tm2.1Rng>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0004215IC57BL6Klf5tm21RngKlf5tm21RngTgPostncre1Sjc0Klf5tm21RngTgPostncre1Sjc
• increased sensitivity to induced morbidity/mortality_Klf5<tm2.1Rng>/Klf5<tm2.1Rng>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0009763IC57BL6Klf5tm21RngKlf5tm21RngTgPostncre1Sjc0Klf5tm21RngTgPostncre1Sjc
• cardiac hypertrophy_Klf5<tm1Rng>/Klf5<+>
  http://metadb.riken.jp/0001625I129SvKlf5tm1RngKlf5Klf5tm1RngKlf5
• pulmonary edema_Klf5<tm2.1Rng>/Klf5<tm2.1Rng>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0003828IC57BL6Klf5tm21RngKlf5tm21RngTgPostncre1Sjc0Klf5tm21RngTgPostncre1Sjc
• pulmonary vascular congestion_Klf5<tm2.1Rng>/Klf5<tm2.1Rng>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0010018IC57BL6Klf5tm21RngKlf5tm21RngTgPostncre1Sjc0Klf5tm21RngTgPostncre1Sjc
• altered response of heart to induced stress_Klf5<tm2.1Rng>/Klf5<tm2.1Rng>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0004484IC57BL6Klf5tm21RngKlf5tm21RngTgPostncre1Sjc0Klf5tm21RngTgPostncre1Sjc
• decreased heart weight_Klf5<tm1Rng>/Klf5<+>
  http://metadb.riken.jp/0002834I129SvKlf5tm1RngKlf5Klf5tm1RngKlf5
• weight loss_Klf5<tm2.1Rng>/Klf5<tm2.1Rng>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0001263IC57BL6Klf5tm21RngKlf5tm21RngTgPostncre1Sjc0Klf5tm21RngTgPostncre1Sjc
• increased wet-to-dry lung weight ratio_Klf5<tm2.1Rng>/Klf5<tm2.1Rng>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0011163IC57BL6Klf5tm21RngKlf5tm21RngTgPostncre1Sjc0Klf5tm21RngTgPostncre1Sjc
• abnormal heart left ventricle morphology_Klf5<tm2.1Rng>/Klf5<tm2.1Rng>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0003921IC57BL6Klf5tm21RngKlf5tm21RngTgPostncre1Sjc0Klf5tm21RngTgPostncre1Sjc
• decreased heart weight_Klf5<tm2.1Rng>/Klf5<tm2.1Rng>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0002834IC57BL6Klf5tm21RngKlf5tm21RngTgPostncre1Sjc0Klf5tm21RngTgPostncre1Sjc
• increased pulmonary respiratory rate_Klf5<tm2.1Rng>/Klf5<tm2.1Rng>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0005573IC57BL6Klf5tm21RngKlf5tm21RngTgPostncre1Sjc0Klf5tm21RngTgPostncre1Sjc
• pulmonary alveolar edema_Klf5<tm2.1Rng>/Klf5<tm2.1Rng>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0010894IC57BL6Klf5tm21RngKlf5tm21RngTgPostncre1Sjc0Klf5tm21RngTgPostncre1Sjc
• cardiac interstitial fibrosis_Klf5<tm2.1Rng>/Klf5<tm2.1Rng>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0005608IC57BL6Klf5tm21RngKlf5tm21RngTgPostncre1Sjc0Klf5tm21RngTgPostncre1Sjc
• increased heart left ventricle size_Klf5<tm2.1Rng>/Klf5<tm2.1Rng>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0010579IC57BL6Klf5tm21RngKlf5tm21RngTgPostncre1Sjc0Klf5tm21RngTgPostncre1Sjc
• abnormal cardiovascular system physiology_Klf5<tm2.1Rng>/Klf5<tm2.1Rng>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0001544IC57BL6Klf5tm21RngKlf5tm21RngTgPostncre1Sjc0Klf5tm21RngTgPostncre1Sjc
• abnormal myocardial fiber morphology_Klf5<tm2.1Rng>/Klf5<tm2.1Rng>,Tg(Postn-cre)1Sjc/0
  http://metadb.riken.jp/0000278IC57BL6Klf5tm21RngKlf5tm21RngTgPostncre1Sjc0Klf5tm21RngTgPostncre1Sjc