Shannon E. Powers, et.al., Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation., Development (Cambridge, England), 2010, 137

http://rdf.ncbi.nlm.nih.gov/pubmed/20040491

Shannon E. Powers, et.al., Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation., Development (Cambridge, England), 2010, 137

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tgif2<tm1Dwot>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437419

class

http://purl.org/net/cito/citesAsAuthority

• Tgif2<tm1Dwot>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437419

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• failure of heart looping_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0004251I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• abnormal proximal-distal axis patterning_Tgif1<tm1Dwot>/Tgif1<tm1Dwot>,Tgif2<tm1Dwot>/Tgif2<+>
  http://metadb.riken.jp/0001705I129SSvEv129X1SvJC57BL6JTgif1tm1DwotTgif1tm1DwotTgif2tm1DwotTgif2Tgif1tm1DwotTgif2Tgif2tm1Dwot
• abnormal direction of heart looping_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0004252I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• abnormal germ layer development_Tgif1<tm1Dwot>/Tgif1<tm1Dwot>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0001674I129SSvEv129X1SvJC57BL6JTgif1tm1DwotTgif1tm1DwotTgif2tm1DwotTgif2tm1DwotTgif2tm1DwotTgif1tm1Dwot
• reduced fertility_Tgif1<tm1Dwot>/Tgif1<+>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0001921I129SSvEv129X1SvJC57BL6JTgif1tm1DwotTgif1Tgif2tm1DwotTgif2tm1DwotTgif1tm1DwotTgif1Tgif2tm1Dwot
• abnormal proximal-distal axis patterning_Tgif1<tm1Dwot>/Tgif1<+>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0001705I129SSvEv129X1SvJC57BL6JTgif1tm1DwotTgif1Tgif2tm1DwotTgif2tm1DwotTgif1tm1DwotTgif1Tgif2tm1Dwot
• abnormal heart looping_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0000269I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• embryonic lethality during organogenesis, complete penetrance_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0011098I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• decreased body size_Tgif1<tm1Dwot>/Tgif1<tm1Dwot>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0001265I129SSvEv129X1SvJC57BL6JTgif1tm1DwotTgif1tm1DwotTgif2tm1DwotTgif2tm1DwotTgif2tm1DwotTgif1tm1Dwot
• decreased embryonic epiblast cell proliferation_Tgif1<tm1Dwot>/Tgif1<tm1Dwot>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0011192I129SSvEv129X1SvJC57BL6JTgif1tm1DwotTgif1tm1DwotTgif2tm1DwotTgif2tm1DwotTgif2tm1DwotTgif1tm1Dwot
• reduced fertility_Tgif1<tm1Dwot>/Tgif1<tm1Dwot>,Tgif2<tm1Dwot>/Tgif2<+>
  http://metadb.riken.jp/0001921I129SSvEv129X1SvJC57BL6JTgif1tm1DwotTgif1tm1DwotTgif2tm1DwotTgif2Tgif1tm1DwotTgif2Tgif2tm1Dwot
• abnormal rostral-caudal axis patterning_Tgif1<tm1Dwot>/Tgif1<tm1Dwot>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0005221I129SSvEv129X1SvJC57BL6JTgif1tm1DwotTgif1tm1DwotTgif2tm1DwotTgif2tm1DwotTgif2tm1DwotTgif1tm1Dwot
• abnormal mesoderm development_Tgif1<tm1Dwot>/Tgif1<tm1Dwot>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0001680I129SSvEv129X1SvJC57BL6JTgif1tm1DwotTgif1tm1DwotTgif2tm1DwotTgif2tm1DwotTgif2tm1DwotTgif1tm1Dwot
• decreased body size_Tgif1<tm1Dwot>/Tgif1<+>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0001265I129SSvEv129X1SvJC57BL6JTgif1tm1DwotTgif1Tgif2tm1DwotTgif2tm1DwotTgif1tm1DwotTgif1Tgif2tm1Dwot
• abnormal embryonic epiblast morphology_Tgif1<tm1Dwot>/Tgif1<tm1Dwot>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0003886I129SSvEv129X1SvJC57BL6JTgif1tm1DwotTgif1tm1DwotTgif2tm1DwotTgif2tm1DwotTgif2tm1DwotTgif1tm1Dwot
• no abnormal phenotype detected_Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0002169I129SSvEvC57BL6JTgif2tm1DwotTgif2tm1DwotTgif2tm1Dwot
• embryonic lethality during organogenesis, complete penetrance_Tgif1<tm1Dwot>/Tgif1<tm1Dwot>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0011098I129SSvEv129X1SvJC57BL6JTgif1tm1DwotTgif1tm1DwotTgif2tm1DwotTgif2tm1DwotTgif2tm1DwotTgif1tm1Dwot
• abnormal proximal-distal axis patterning_Tgif1<tm1Dwot>/Tgif1<tm1Dwot>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0001705I129SSvEv129X1SvJC57BL6JTgif1tm1DwotTgif1tm1DwotTgif2tm1DwotTgif2tm1DwotTgif2tm1DwotTgif1tm1Dwot
• abnormal primitive streak elongation_Tgif1<tm1Dwot>/Tgif1<tm1Dwot>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0012685I129SSvEv129X1SvJC57BL6JTgif1tm1DwotTgif1tm1DwotTgif2tm1DwotTgif2tm1DwotTgif2tm1DwotTgif1tm1Dwot
• abnormal primitive streak elongation_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0012685I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• decreased body size_Tgif1<tm1Dwot>/Tgif1<tm1Dwot>,Tgif2<tm1Dwot>/Tgif2<+>
  http://metadb.riken.jp/0001265I129SSvEv129X1SvJC57BL6JTgif1tm1DwotTgif1tm1DwotTgif2tm1DwotTgif2Tgif1tm1DwotTgif2Tgif2tm1Dwot
• abnormal left-right axis patterning_Nodal<tm1Rob>/Nodal<+>,Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0001706I129SSvEvC57BL6C57BL6JCBANodaltm1RobNodalTgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcNodaltm1RobNodalTgif1tm1CawTgif2tm1Dwot
• abnormal left-right axis patterning_Tg(Sox2-cre)1Amc/0,Tgif1<tm1Caw>/Tgif1<tm1Caw>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0001706I129SSvEvC57BL6C57BL6JCBATgSox2cre1Amc0Tgif1tm1CawTgif1tm1CawTgif2tm1DwotTgif2tm1DwotTgSox2cre1AmcTgif1tm1CawTgif2tm1Dwot
• abnormal gastrulation_Tgif1<tm1Dwot>/Tgif1<tm1Dwot>,Tgif2<tm1Dwot>/Tgif2<tm1Dwot>
  http://metadb.riken.jp/0001695I129SSvEv129X1SvJC57BL6JTgif1tm1DwotTgif1tm1DwotTgif2tm1DwotTgif2tm1DwotTgif2tm1DwotTgif1tm1Dwot

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD05684
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD05684
• CD02531
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02531