Magali. Michaud, et.al., Neuromuscular defects and breathing disorders in a new mouse model of spinal muscular atrophy., Neurobiology of disease, 2010, 38

http://rdf.ncbi.nlm.nih.gov/pubmed/20085811

Magali. Michaud, et.al., Neuromuscular defects and breathing disorders in a new mouse model of spinal muscular atrophy., Neurobiology of disease, 2010, 38

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal sciatic nerve morphology_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0002651B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• slow postnatal weight gain_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)46Tro/Tg(SMN2)46Tro
  http://metadb.riken.jp/0008489B6CgTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN246TroTgSMN246TroTgSMN246TroSmn1tm1Msd
• embryonic lethality_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0
  http://metadb.riken.jp/0008762B6CgTgSMN211TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0Smn1tm1MsdTgSMN211Tro
• embryonic lethality_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0008762B6CgTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN246Tro0Smn1tm1MsdTgSMN246Tro
• apnea_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0001957B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• abnormal autopod morphology_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0000572B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• abnormal synaptic bouton morphology_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0008571B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• abnormal outer ear morphology_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0002177B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• decreased pulmonary ventilation_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0005576B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• weight loss_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/Tg(SMN2)11Tro
  http://metadb.riken.jp/0001263B6CgTgSMN211TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211TroTgSMN211TroTgSMN211TroSmn1tm1Msd
• abnormal tail morphology_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0002111B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• decreased motor neuron number_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0000939B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• postnatal lethality, complete penetrance_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/Tg(SMN2)11Tro
  http://metadb.riken.jp/0011085B6CgTgSMN211TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211TroTgSMN211TroTgSMN211TroSmn1tm1Msd
• increased thermal nociceptive threshold_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0001973B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• abnormal neuromuscular synapse morphology_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0001053B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• abnormal gait_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0001406B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• muscular atrophy_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0002269B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• abnormal respiratory mechanics_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0002314B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• abnormal tail morphology_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)46Tro/Tg(SMN2)46Tro
  http://metadb.riken.jp/0002111B6CgTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN246TroTgSMN246TroTgSMN246TroSmn1tm1Msd
• decreased survivor rate_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0008770B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• abnormal muscle electrophysiology_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0004145B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• axon degeneration_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0005405B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• abnormal respiration_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0001943B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• postnatal lethality, incomplete penetrance_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0011086B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• positive geotaxis_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0005356B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• abnormal autopod morphology_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)46Tro/Tg(SMN2)46Tro
  http://metadb.riken.jp/0000572B6CgTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN246TroTgSMN246TroTgSMN246TroSmn1tm1Msd
• abnormal skeletal muscle fiber morphology_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0003084B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• abnormal outer ear morphology_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)46Tro/Tg(SMN2)46Tro
  http://metadb.riken.jp/0002177B6CgTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN246TroTgSMN246TroTgSMN246TroSmn1tm1Msd
• slow postnatal weight gain_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0008489B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• progressive muscle weakness_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0000748B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd
• abnormal phrenic nerve morphology_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
  http://metadb.riken.jp/0001078B6CgTgSMN211TroTgSMN246TroSmn1tm1MsdJSmn1tm1MsdSmn1tm1MsdTgSMN211Tro0TgSMN246Tro0TgSMN246TroTgSMN211TroSmn1tm1Msd