Hans. Wils, et.al., TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107

http://rdf.ncbi.nlm.nih.gov/pubmed/20133711

Hans. Wils, et.al., TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Thy1-TARDBP)6Singh
  http://metadb.riken.jp/db/mgi_rdf/MGI:4438491
• Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/db/mgi_rdf/MGI:4438490

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal spinal cord morphology_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0000955IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• abnormal subiculum morphology_Tg(Thy1-TARDBP)4Singh/0
  http://metadb.riken.jp/0008287IC57BL6JSJLJTgThy1TARDBP4Singh0TgThy1TARDBP4Singh
• short stride length_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0001407IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• neuronal intranuclear inclusions_Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh
  http://metadb.riken.jp/0004191IC57BL6C57BL6JSJLTgThy1TARDBP6SinghTgThy1TARDBP6SinghTgThy1TARDBP6Singh
• impaired coordination_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0001405IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• decreased neuron number_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0008948IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• astrocytosis_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0003354IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• abnormal spinal cord ventral horn morphology_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0005112IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• abnormal gait_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0001406IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• limb grasping_Tg(Thy1-TARDBP)4Singh/0
  http://metadb.riken.jp/0001513IC57BL6JSJLJTgThy1TARDBP4Singh0TgThy1TARDBP4Singh
• abnormal hippocampus morphology_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0000807IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• Purkinje cell degeneration_Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh
  http://metadb.riken.jp/0000876IC57BL6C57BL6JSJLTgThy1TARDBP6SinghTgThy1TARDBP6SinghTgThy1TARDBP6Singh
• muscle spasm_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0000743IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• paralysis_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0000753IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• abnormal neocortex morphology_Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh
  http://metadb.riken.jp/0008547IC57BL6C57BL6JSJLTgThy1TARDBP6SinghTgThy1TARDBP6SinghTgThy1TARDBP6Singh
• abnormal somatosensory cortex morphology_Tg(Thy1-TARDBP)4Singh/0
  http://metadb.riken.jp/0000859IC57BL6JSJLJTgThy1TARDBP4Singh0TgThy1TARDBP4Singh
• impaired coordination_Tg(Thy1-TARDBP)4Singh/0
  http://metadb.riken.jp/0001405IC57BL6JSJLJTgThy1TARDBP4Singh0TgThy1TARDBP4Singh
• abnormal spinal cord ventral horn morphology_Tg(Thy1-TARDBP)4Singh/0
  http://metadb.riken.jp/0005112IC57BL6JSJLJTgThy1TARDBP4Singh0TgThy1TARDBP4Singh
• decreased neuron number_Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh
  http://metadb.riken.jp/0008948IC57BL6C57BL6JSJLTgThy1TARDBP6SinghTgThy1TARDBP6SinghTgThy1TARDBP6Singh
• decreased motor neuron number_Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh
  http://metadb.riken.jp/0000939IC57BL6C57BL6JSJLTgThy1TARDBP6SinghTgThy1TARDBP6SinghTgThy1TARDBP6Singh
• abnormal spinal cord ventral horn morphology_Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh
  http://metadb.riken.jp/0005112IC57BL6C57BL6JSJLTgThy1TARDBP6SinghTgThy1TARDBP6SinghTgThy1TARDBP6Singh
• abnormal subiculum morphology_Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh
  http://metadb.riken.jp/0008287IC57BL6C57BL6JSJLTgThy1TARDBP6SinghTgThy1TARDBP6SinghTgThy1TARDBP6Singh
• impaired coordination_Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh
  http://metadb.riken.jp/0001405IC57BL6C57BL6JSJLTgThy1TARDBP6SinghTgThy1TARDBP6SinghTgThy1TARDBP6Singh
• Purkinje cell degeneration_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0000876IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• Purkinje cell degeneration_Tg(Thy1-TARDBP)4Singh/0
  http://metadb.riken.jp/0000876IC57BL6JSJLJTgThy1TARDBP4Singh0TgThy1TARDBP4Singh
• astrocytosis_Tg(Thy1-TARDBP)4Singh/0
  http://metadb.riken.jp/0003354IC57BL6JSJLJTgThy1TARDBP4Singh0TgThy1TARDBP4Singh
• limb grasping_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0001513IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• abnormal hippocampus morphology_Tg(Thy1-TARDBP)4Singh/0
  http://metadb.riken.jp/0000807IC57BL6JSJLJTgThy1TARDBP4Singh0TgThy1TARDBP4Singh
• abnormal neocortex morphology_Tg(Thy1-TARDBP)4Singh/0
  http://metadb.riken.jp/0008547IC57BL6JSJLJTgThy1TARDBP4Singh0TgThy1TARDBP4Singh
• neuronal intranuclear inclusions_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0004191IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• abnormal hippocampus CA3 region morphology_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0008267IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• limb grasping_Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh
  http://metadb.riken.jp/0001513IC57BL6C57BL6JSJLTgThy1TARDBP6SinghTgThy1TARDBP6SinghTgThy1TARDBP6Singh
• abnormal somatosensory cortex morphology_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0000859IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• abnormal spinal cord morphology_Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh
  http://metadb.riken.jp/0000955IC57BL6C57BL6JSJLTgThy1TARDBP6SinghTgThy1TARDBP6SinghTgThy1TARDBP6Singh
• premature death_Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh
  http://metadb.riken.jp/0002083IC57BL6C57BL6JSJLTgThy1TARDBP6SinghTgThy1TARDBP6SinghTgThy1TARDBP6Singh
• decreased motor neuron number_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0000939IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• increased neuron apoptosis_Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh
  http://metadb.riken.jp/0003203IC57BL6C57BL6JSJLTgThy1TARDBP6SinghTgThy1TARDBP6SinghTgThy1TARDBP6Singh
• astrocytosis_Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh
  http://metadb.riken.jp/0003354IC57BL6C57BL6JSJLTgThy1TARDBP6SinghTgThy1TARDBP6SinghTgThy1TARDBP6Singh
• microgliosis_Tg(Thy1-TARDBP)4Singh/0
  http://metadb.riken.jp/0008918IC57BL6JSJLJTgThy1TARDBP4Singh0TgThy1TARDBP4Singh
• microgliosis_Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh
  http://metadb.riken.jp/0008918IC57BL6C57BL6JSJLTgThy1TARDBP6SinghTgThy1TARDBP6SinghTgThy1TARDBP6Singh
• abnormal hippocampus morphology_Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh
  http://metadb.riken.jp/0000807IC57BL6C57BL6JSJLTgThy1TARDBP6SinghTgThy1TARDBP6SinghTgThy1TARDBP6Singh
• motor neuron degeneration_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0000938IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• abnormal limb posture_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0004263IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• premature death_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0002083IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• microgliosis_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0008918IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• abnormal somatosensory cortex morphology_Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh
  http://metadb.riken.jp/0000859IC57BL6C57BL6JSJLTgThy1TARDBP6SinghTgThy1TARDBP6SinghTgThy1TARDBP6Singh
• abnormal neocortex morphology_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0008547IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh
• neuronal intranuclear inclusions_Tg(Thy1-TARDBP)4Singh/0
  http://metadb.riken.jp/0004191IC57BL6JSJLJTgThy1TARDBP4Singh0TgThy1TARDBP4Singh
• abnormal subiculum morphology_Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/0008287IC57BL6JSJLJTgThy1TARDBP4SinghTgThy1TARDBP4SinghTgThy1TARDBP4Singh

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Thy1-TARDBP)6Singh
  http://metadb.riken.jp/db/mgi_rdf/MGI:4438491
• Tg(Thy1-TARDBP)4Singh
  http://metadb.riken.jp/db/mgi_rdf/MGI:4438490