Michael. Berger, et.al., An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence., Nature immunology, 2010, 11

http://rdf.ncbi.nlm.nih.gov/pubmed/20190759

Michael. Berger, et.al., An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence., Nature immunology, 2010, 11

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Slfn3<tm1Aki>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4441068
• Slfn1<tm1Aki>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4441069
• Slfn2<m1Btlr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3850348

class

http://purl.org/net/cito/citesAsAuthority

• Slfn3<tm1Aki>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4441068
• Slfn1<tm1Aki>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4441069
• Slfn2<m1Btlr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3850348

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased neutrophil cell number_Slfn2<m1Btlr>/Slfn2<m1Btlr>
  http://metadb.riken.jp/0000219C57BL6JSlfn2m1BtlrSlfn2m1BtlrSlfn2m1BtlrSlfn2m1Btlr
• decreased CD4-positive, alpha beta T cell number_Slfn2<m1Btlr>/Slfn2<m1Btlr>
  http://metadb.riken.jp/0008075C57BL6JSlfn2m1BtlrSlfn2m1BtlrSlfn2m1BtlrSlfn2m1Btlr
• decreased CD8-positive, alpha-beta T cell number_Slfn2<m1Btlr>/Slfn2<m1Btlr>
  http://metadb.riken.jp/0008079C57BL6JSlfn2m1BtlrSlfn2m1BtlrSlfn2m1BtlrSlfn2m1Btlr
• increased susceptibility to bacterial infection induced morbidity/mortality_Slfn2<m1Btlr>/Slfn2<m1Btlr>
  http://metadb.riken.jp/0009788C57BL6JSlfn2m1BtlrSlfn2m1BtlrSlfn2m1BtlrSlfn2m1Btlr
• increased susceptibility to viral infection induced morbidity/mortality_Slfn2<m1Btlr>/Slfn2<m1Btlr>
  http://metadb.riken.jp/0009791C57BL6JSlfn2m1BtlrSlfn2m1BtlrSlfn2m1BtlrSlfn2m1Btlr
• increased susceptibility to bacterial infection_Slfn2<m1Btlr>/Slfn2<m1Btlr>
  http://metadb.riken.jp/0002412C57BL6JSlfn2m1BtlrSlfn2m1BtlrSlfn2m1BtlrSlfn2m1Btlr
• abnormal T cell activation_Slfn2<m1Btlr>/Slfn2<m1Btlr>
  http://metadb.riken.jp/0001828C57BL6JSlfn2m1BtlrSlfn2m1BtlrSlfn2m1BtlrSlfn2m1Btlr
• abnormal leukocyte physiology_Slfn2<m1Btlr>/Slfn2<m1Btlr>
  http://metadb.riken.jp/0002442C57BL6JSlfn2m1BtlrSlfn2m1BtlrSlfn2m1BtlrSlfn2m1Btlr
• decreased monocyte cell number_Slfn2<m1Btlr>/Slfn2<m1Btlr>
  http://metadb.riken.jp/0000223C57BL6JSlfn2m1BtlrSlfn2m1BtlrSlfn2m1BtlrSlfn2m1Btlr
• decreased T cell proliferation_Slfn2<m1Btlr>/Slfn2<m1Btlr>
  http://metadb.riken.jp/0005095C57BL6JSlfn2m1BtlrSlfn2m1BtlrSlfn2m1BtlrSlfn2m1Btlr
• increased susceptibility to viral infection_Slfn2<m1Btlr>/Slfn2<m1Btlr>
  http://metadb.riken.jp/0002418C57BL6JSlfn2m1BtlrSlfn2m1BtlrSlfn2m1BtlrSlfn2m1Btlr
• abnormal T cell proliferation_Slfn2<m1Btlr>/Slfn2<m1Btlr>
  http://metadb.riken.jp/0005094C57BL6JSlfn2m1BtlrSlfn2m1BtlrSlfn2m1BtlrSlfn2m1Btlr
• increased T cell apoptosis_Slfn2<m1Btlr>/Slfn2<m1Btlr>
  http://metadb.riken.jp/0006413C57BL6JSlfn2m1BtlrSlfn2m1BtlrSlfn2m1BtlrSlfn2m1Btlr
• abnormal nitric oxide homeostasis_Slfn2<m1Btlr>/Slfn2<m1Btlr>
  http://metadb.riken.jp/0003957C57BL6JSlfn2m1BtlrSlfn2m1BtlrSlfn2m1BtlrSlfn2m1Btlr

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD18872
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD18872
• CD38733
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD38733
• CD40412
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD40412