Sylvie. Giuriato, et.al., Conditional TPM3-ALK and NPM-ALK transgenic mice develop reversible ALK-positive early B-cell lymphoma/leukemia., Blood, 2010, 115

http://rdf.ncbi.nlm.nih.gov/pubmed/20223922

Sylvie. Giuriato, et.al., Conditional TPM3-ALK and NPM-ALK transgenic mice develop reversible ALK-positive early B-cell lymphoma/leukemia., Blood, 2010, 115

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-TPM3/ALK,-luc)2Gde
  http://metadb.riken.jp/db/mgi_rdf/MGI:5766489
• Tg(tetO-NPM1/ALK,-luc)2Gde
  http://metadb.riken.jp/db/mgi_rdf/MGI:5766488

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal dermal layer morphology_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-TPM3/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0001243IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetOTPM3ALKluc2Gde0TgEmuSRtTa83BopTgtetOTPM3ALKluc2Gde
• abnormal dermal layer morphology_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-NPM1/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0001243IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetONPM1ALKluc2Gde0TgtetONPM1ALKluc2GdeTgEmuSRtTa83Bop
• increased leukemia incidence_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-NPM1/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0002026IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetONPM1ALKluc2Gde0TgtetONPM1ALKluc2GdeTgEmuSRtTa83Bop
• increased B cell derived lymphoma incidence_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-NPM1/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0002023IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetONPM1ALKluc2Gde0TgtetONPM1ALKluc2GdeTgEmuSRtTa83Bop
• enlarged spleen_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-TPM3/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0000691IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetOTPM3ALKluc2Gde0TgEmuSRtTa83BopTgtetOTPM3ALKluc2Gde
• epidermal hyperplasia_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-NPM1/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0001222IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetONPM1ALKluc2Gde0TgtetONPM1ALKluc2GdeTgEmuSRtTa83Bop
• epidermal hyperplasia_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-TPM3/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0001222IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetOTPM3ALKluc2Gde0TgEmuSRtTa83BopTgtetOTPM3ALKluc2Gde
• premature death_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-TPM3/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0002083IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetOTPM3ALKluc2Gde0TgEmuSRtTa83BopTgtetOTPM3ALKluc2Gde
• postnatal growth retardation_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-NPM1/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0001732IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetONPM1ALKluc2Gde0TgtetONPM1ALKluc2GdeTgEmuSRtTa83Bop
• premature death_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-NPM1/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0002083IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetONPM1ALKluc2Gde0TgtetONPM1ALKluc2GdeTgEmuSRtTa83Bop
• embryonic lethality, complete penetrance_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-NPM1/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0011092IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetONPM1ALKluc2Gde0TgtetONPM1ALKluc2GdeTgEmuSRtTa83Bop
• abnormal skin morphology_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-NPM1/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0002060IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetONPM1ALKluc2Gde0TgtetONPM1ALKluc2GdeTgEmuSRtTa83Bop
• abnormal skin morphology_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-TPM3/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0002060IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetOTPM3ALKluc2Gde0TgEmuSRtTa83BopTgtetOTPM3ALKluc2Gde
• increased leukemia incidence_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-TPM3/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0002026IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetOTPM3ALKluc2Gde0TgEmuSRtTa83BopTgtetOTPM3ALKluc2Gde
• enlarged lymph nodes_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-NPM1/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0000702IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetONPM1ALKluc2Gde0TgtetONPM1ALKluc2GdeTgEmuSRtTa83Bop
• embryonic lethality, complete penetrance_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-TPM3/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0011092IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetOTPM3ALKluc2Gde0TgEmuSRtTa83BopTgtetOTPM3ALKluc2Gde
• increased B cell derived lymphoma incidence_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-TPM3/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0002023IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetOTPM3ALKluc2Gde0TgEmuSRtTa83BopTgtetOTPM3ALKluc2Gde
• enlarged spleen_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-NPM1/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0000691IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetONPM1ALKluc2Gde0TgtetONPM1ALKluc2GdeTgEmuSRtTa83Bop
• enlarged lymph nodes_Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop,Tg(tetO-TPM3/ALK,-luc)2Gde/0
  http://metadb.riken.jp/0000702IFVBNTgEmuSRtTa83BopTgEmuSRtTa83BopTgtetOTPM3ALKluc2Gde0TgEmuSRtTa83BopTgtetOTPM3ALKluc2Gde

class

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-TPM3/ALK,-luc)2Gde
  http://metadb.riken.jp/db/mgi_rdf/MGI:5766489
• Tg(tetO-NPM1/ALK,-luc)2Gde
  http://metadb.riken.jp/db/mgi_rdf/MGI:5766488