Ingo. Kleiter, et.al., Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis., Brain : a journal of neurology, 2010, 133

http://rdf.ncbi.nlm.nih.gov/pubmed/20354004

Ingo. Kleiter, et.al., Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis., Brain : a journal of neurology, 2010, 133

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Smad7<tm1.1Ink>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5426017
• Smad7<tm1.2Ink>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5426021

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased susceptibility to experimental autoimmune encephalomyelitis_Smad7<tm1.1Ink>/Smad7<tm1.1Ink>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0004800IC57BL6DBA2Smad7tm11InkSmad7tm11InkTgCd4cre1Cwi0Smad7tm11InkTgCd4cre1Cwi
• preweaning lethality, complete penetrance_Smad7<tm1.2Ink>/Smad7<tm1.2Ink>
  http://metadb.riken.jp/0011100IBALBcJC57BL6Smad7tm12InkSmad7tm12InkSmad7tm12Ink
• paralysis_Smad7<tm1.1Ink>/Smad7<tm1.1Ink>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0000753IC57BL6DBA2Smad7tm11InkSmad7tm11InkTgCd4cre1Cwi0Smad7tm11InkTgCd4cre1Cwi
• decreased interferon-gamma secretion_Smad7<tm1.1Ink>/Smad7<tm1.1Ink>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008567IC57BL6DBA2Smad7tm11InkSmad7tm11InkTgCd4cre1Cwi0Smad7tm11InkTgCd4cre1Cwi
• decreased interleukin-9 secretion_Smad7<tm1.1Ink>/Smad7<tm1.1Ink>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008712IC57BL6DBA2Smad7tm11InkSmad7tm11InkTgCd4cre1Cwi0Smad7tm11InkTgCd4cre1Cwi
• decreased transforming growth factor level_Tg(Cd2-Smad7)#Chbe/0
  http://metadb.riken.jp/0008838IC57BL6TgCd2Smad7Chbe0TgCd2Smad7Chbe
• decreased T cell proliferation_Smad7<tm1.1Ink>/Smad7<tm1.1Ink>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005095IC57BL6DBA2Smad7tm11InkSmad7tm11InkTgCd4cre1Cwi0Smad7tm11InkTgCd4cre1Cwi
• abnormal T-helper 1 cell differentiation_Smad7<tm1.1Ink>/Smad7<tm1.1Ink>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008088IC57BL6DBA2Smad7tm11InkSmad7tm11InkTgCd4cre1Cwi0Smad7tm11InkTgCd4cre1Cwi
• increased susceptibility to experimental autoimmune encephalomyelitis_Tg(Cd2-Smad7)#Chbe/0
  http://metadb.riken.jp/0004799IC57BL6TgCd2Smad7Chbe0TgCd2Smad7Chbe
• abnormal T-helper 1 cell differentiation_Tg(Cd2-Smad7)#Chbe/0
  http://metadb.riken.jp/0008088IC57BL6TgCd2Smad7Chbe0TgCd2Smad7Chbe
• decreased interleukin-17 secretion_Tg(Cd2-Smad7)#Chbe/0
  http://metadb.riken.jp/0008682IC57BL6TgCd2Smad7Chbe0TgCd2Smad7Chbe
• decreased activated T cell number_Smad7<tm1.1Ink>/Smad7<tm1.1Ink>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001830IC57BL6DBA2Smad7tm11InkSmad7tm11InkTgCd4cre1Cwi0Smad7tm11InkTgCd4cre1Cwi
• decreased interleukin-9 secretion_Tg(Cd2-Smad7)#Chbe/0
  http://metadb.riken.jp/0008712IC57BL6TgCd2Smad7Chbe0TgCd2Smad7Chbe
• increased interferon-gamma secretion_Tg(Cd2-Smad7)#Chbe/0
  http://metadb.riken.jp/0008566IC57BL6TgCd2Smad7Chbe0TgCd2Smad7Chbe
• increased transforming growth factor level_Smad7<tm1.1Ink>/Smad7<tm1.1Ink>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008837IC57BL6DBA2Smad7tm11InkSmad7tm11InkTgCd4cre1Cwi0Smad7tm11InkTgCd4cre1Cwi
• decreased interleukin-10 secretion_Tg(Cd2-Smad7)#Chbe/0
  http://metadb.riken.jp/0008661IC57BL6TgCd2Smad7Chbe0TgCd2Smad7Chbe
• increased sensitivity to induced morbidity/mortality_Tg(Cd2-Smad7)#Chbe/0
  http://metadb.riken.jp/0009763IC57BL6TgCd2Smad7Chbe0TgCd2Smad7Chbe

class

http://purl.org/net/cito/citesAsAuthority

• Smad7<tm1.1Ink>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5426017
• Smad7<tm1.2Ink>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5426021