Janaky. Coomaraswamy, et.al., Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107

http://rdf.ncbi.nlm.nih.gov/pubmed/20385796

Janaky. Coomaraswamy, et.al., Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp-ITM2B*)6Jckr
  http://metadb.riken.jp/db/mgi_rdf/MGI:4452484
• Tg(Prnp-ITM2B*)7Jckr
  http://metadb.riken.jp/db/mgi_rdf/MGI:4452483

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased body weight_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0001262C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr
• abnormal neurite morphology_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0008415C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr
• increased anxiety-related response_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0001363C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr
• amyloidosis_Tg(Prnp-ITM2B*)7Jckr/0,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
  http://metadb.riken.jp/0000604C57BL6TgPrnpITM2B7JckrTgThy1APPSwThy1PSEN1L166P21JckrTgPrnpITM2B7Jckr0TgThy1APPSwThy1PSEN1L166P21Jckr0TgPrnpITM2B7JckrTgThy1APPSwThy1PSEN1L166P21Jckr
• astrocytosis_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0003354C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr
• abnormal hippocampus neuron morphology_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0009939C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr
• abnormal brain vasculature morphology_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0004950C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr
• neurofibrillary tangles_Tg(Prnp-ITM2B*)7Jckr/0,Tg(Thy1-MAPT*P301S)2541Godt/0
  http://metadb.riken.jp/0003214B6CgTgPrnpITM2B7JckrTgThy1MAPTP301S2541GodtTgPrnpITM2B7Jckr0TgThy1MAPTP301S2541Godt0TgPrnpITM2B7JckrTgThy1MAPTP301S2541Godt
• slow postnatal weight gain_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0008489C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr
• hypoactivity_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0001402C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr
• increased thigmotaxis_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0002797C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr
• amyloidosis_Tg(Prnp-ITM2B*)6Jckr/0,Tg(Thy1-APP)3Somm/0
  http://metadb.riken.jp/0000604B6CgTgPrnpITM2B6JckrTgThy1APP3SommTgPrnpITM2B6Jckr0TgThy1APP3Somm0TgPrnpITM2B6JckrTgThy1APP3Somm
• intracerebral hemorrhage_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0001916C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr
• tau protein deposits_Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0,Tg(Thy1-MAPT*P301S)2541Godt/0
  http://metadb.riken.jp/0004250B6CgTgThy1APPSwThy1PSEN1L166P21JckrTgThy1MAPTP301S2541GodtTgThy1APPSwThy1PSEN1L166P21Jckr0TgThy1MAPTP301S2541Godt0TgThy1MAPTP301S2541GodtTgThy1APPSwThy1PSEN1L166P21Jckr
• tau protein deposits_Tg(Prnp-ITM2B*)7Jckr/0,Tg(Thy1-MAPT*P301S)2541Godt/0
  http://metadb.riken.jp/0004250B6CgTgPrnpITM2B7JckrTgThy1MAPTP301S2541GodtTgPrnpITM2B7Jckr0TgThy1MAPTP301S2541Godt0TgPrnpITM2B7JckrTgThy1MAPTP301S2541Godt
• kyphosis_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0000160C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr
• behavioral despair_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0002573C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr
• microgliosis_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0008918C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr
• abnormal spatial learning_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0001463C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr
• impaired swimming_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0001522C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr
• abnormal synaptic bouton morphology_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0008571C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr
• amyloidosis_Tg(Prnp-ITM2B*)6Jckr/0
  http://metadb.riken.jp/0000604C57BL6TgPrnpITM2B6JckrTgPrnpITM2B6Jckr0TgPrnpITM2B6Jckr
• amyloid beta deposits_Tg(Prnp-ITM2B*)7Jckr/0,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
  http://metadb.riken.jp/0003329C57BL6TgPrnpITM2B7JckrTgThy1APPSwThy1PSEN1L166P21JckrTgPrnpITM2B7Jckr0TgThy1APPSwThy1PSEN1L166P21Jckr0TgPrnpITM2B7JckrTgThy1APPSwThy1PSEN1L166P21Jckr
• decreased vertical activity_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0002757C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr
• amyloid beta deposits_Tg(Prnp-ITM2B*)6Jckr/0,Tg(Thy1-APP)3Somm/0
  http://metadb.riken.jp/0003329B6CgTgPrnpITM2B6JckrTgThy1APP3SommTgPrnpITM2B6Jckr0TgThy1APP3Somm0TgPrnpITM2B6JckrTgThy1APP3Somm
• alopecia_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0000414C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr
• amyloidosis_Tg(Prnp-ITM2B*)7Jckr/0
  http://metadb.riken.jp/0000604C57BL6TgPrnpITM2B7JckrTgPrnpITM2B7Jckr0TgPrnpITM2B7Jckr

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp-ITM2B*)6Jckr
  http://metadb.riken.jp/db/mgi_rdf/MGI:4452484
• Tg(Prnp-ITM2B*)7Jckr
  http://metadb.riken.jp/db/mgi_rdf/MGI:4452483