Antonella. Galli, et.al., Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development., PLoS genetics, 2010, 6

http://rdf.ncbi.nlm.nih.gov/pubmed/20386744

Antonella. Galli, et.al., Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development., PLoS genetics, 2010, 6

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Hand2<tm1.1Zllr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4453960
• Hand2<tm1.2Zllr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4453961

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal pharyngeal arch artery morphology_Hand2<tm1.2Zllr>/Hand2<tm1.2Zllr>
  http://metadb.riken.jp/0002672I129S1Sv129X1SvJBALBcJC57BL6SJLHand2tm12ZllrHand2tm12ZllrHand2tm12Zllr
• dilated aortic sac_Hand2<tm1.2Zllr>/Hand2<tm1.2Zllr>
  http://metadb.riken.jp/0012511I129S1Sv129X1SvJBALBcJC57BL6SJLHand2tm12ZllrHand2tm12ZllrHand2tm12Zllr
• increased apoptosis_Hand2<tm1.1Zllr>/Hand2<tm1.2Zllr>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0006042I129S1Sv129X1SvJBALBcJC57BL6SJLHand2tm11ZllrHand2tm12ZllrTgPrrx1cre1Cjt0Hand2tm11ZllrHand2tm12ZllrTgPrrx1cre1Cjt
• abnormal limb development_Shh<tm1Chg>/Shh<tm1Chg>
  http://metadb.riken.jp/0006279I129S1Sv129X1SvJShhtm1ChgShhtm1ChgShhtm1Chg
• abnormal autopod morphology_Hand2<tm1.1Zllr>/Hand2<tm1.2Zllr>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0000572I129S1Sv129X1SvJBALBcJC57BL6SJLHand2tm11ZllrHand2tm12ZllrTgPrrx1cre1Cjt0Hand2tm11ZllrHand2tm12ZllrTgPrrx1cre1Cjt
• polydactyly_Gli3<Xt-J>/Gli3<Xt-J>
  http://metadb.riken.jp/0000562IC3HHeJGli3XtJGli3XtJGli3XtJ
• distended pericardium_Hand2<tm1.2Zllr>/Hand2<tm1.2Zllr>
  http://metadb.riken.jp/0000292I129S1Sv129X1SvJBALBcJC57BL6SJLHand2tm12ZllrHand2tm12ZllrHand2tm12Zllr
• postaxial polydactyly_Gli3<Xt-J>/Gli3<Xt-J>,Hand2<tm1.1Zllr>/Hand2<tm1.2Zllr>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0009744I129SvBALBcJC3HHeJC57BL6SJLGli3XtJGli3XtJHand2tm11ZllrHand2tm12ZllrTgPrrx1cre1Cjt0Hand2tm11ZllrGli3XtJTgPrrx1cre1CjtHand2tm12Zllr
• abnormal interdigital cell death_Hand2<tm1.1Zllr>/Hand2<tm1.2Zllr>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0009874I129S1Sv129X1SvJBALBcJC57BL6SJLHand2tm11ZllrHand2tm12ZllrTgPrrx1cre1Cjt0Hand2tm11ZllrHand2tm12ZllrTgPrrx1cre1Cjt
• abnormal digit development_Hand2<tm1.1Zllr>/Hand2<tm1.2Zllr>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0006280I129S1Sv129X1SvJBALBcJC57BL6SJLHand2tm11ZllrHand2tm12ZllrTgPrrx1cre1Cjt0Hand2tm11ZllrHand2tm12ZllrTgPrrx1cre1Cjt
• abnormal forelimb stylopod morphology_Gli3<Xt-J>/Gli3<Xt-J>,Hand2<tm1.1Zllr>/Hand2<tm1.2Zllr>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0003854I129SvBALBcJC3HHeJC57BL6SJLGli3XtJGli3XtJHand2tm11ZllrHand2tm12ZllrTgPrrx1cre1Cjt0Hand2tm11ZllrGli3XtJTgPrrx1cre1CjtHand2tm12Zllr
• abnormal forelimb zeugopod morphology_Hand2<tm1.1Zllr>/Hand2<tm1.2Zllr>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0003855I129S1Sv129X1SvJBALBcJC57BL6SJLHand2tm11ZllrHand2tm12ZllrTgPrrx1cre1Cjt0Hand2tm11ZllrHand2tm12ZllrTgPrrx1cre1Cjt
• abnormal autopod morphology_Gli3<Xt-J>/Gli3<Xt-J>,Hand2<tm1.1Zllr>/Hand2<tm1.2Zllr>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0000572I129SvBALBcJC3HHeJC57BL6SJLGli3XtJGli3XtJHand2tm11ZllrHand2tm12ZllrTgPrrx1cre1Cjt0Hand2tm11ZllrGli3XtJTgPrrx1cre1CjtHand2tm12Zllr
• preaxial polydactyly_Gli3<Xt-J>/Gli3<Xt-J>,Hand2<tm1.1Zllr>/Hand2<tm1.2Zllr>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0009743I129SvBALBcJC3HHeJC57BL6SJLGli3XtJGli3XtJHand2tm11ZllrHand2tm12ZllrTgPrrx1cre1Cjt0Hand2tm11ZllrGli3XtJTgPrrx1cre1CjtHand2tm12Zllr
• increased embryonic tissue cell apoptosis_Hand2<tm1.2Zllr>/Hand2<tm1.2Zllr>
  http://metadb.riken.jp/0013504I129S1Sv129X1SvJBALBcJC57BL6SJLHand2tm12ZllrHand2tm12ZllrHand2tm12Zllr
• abnormal forelimb zeugopod morphology_Gli3<Xt-J>/Gli3<Xt-J>,Hand2<tm1.1Zllr>/Hand2<tm1.2Zllr>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0003855I129SvBALBcJC3HHeJC57BL6SJLGli3XtJGli3XtJHand2tm11ZllrHand2tm12ZllrTgPrrx1cre1Cjt0Hand2tm11ZllrGli3XtJTgPrrx1cre1CjtHand2tm12Zllr
• abnormal limb development_Gli3<Xt-J>/Gli3<Xt-J>,Hand2<tm1.1Zllr>/Hand2<tm1.2Zllr>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0006279I129SvBALBcJC3HHeJC57BL6SJLGli3XtJGli3XtJHand2tm11ZllrHand2tm12ZllrTgPrrx1cre1Cjt0Hand2tm11ZllrGli3XtJTgPrrx1cre1CjtHand2tm12Zllr
• embryonic growth retardation_Hand2<tm1.2Zllr>/Hand2<tm1.2Zllr>
  http://metadb.riken.jp/0003984I129S1Sv129X1SvJBALBcJC57BL6SJLHand2tm12ZllrHand2tm12ZllrHand2tm12Zllr
• abnormal hindlimb morphology_Hand2<tm1.1Zllr>/Hand2<tm1.2Zllr>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0000556I129S1Sv129X1SvJBALBcJC57BL6SJLHand2tm11ZllrHand2tm12ZllrTgPrrx1cre1Cjt0Hand2tm11ZllrHand2tm12ZllrTgPrrx1cre1Cjt

class

http://purl.org/net/cito/citesAsAuthority

• Hand2<tm1.1Zllr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4453960
• Hand2<tm1.2Zllr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4453961

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD03962
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD03962
• CD19423
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD19423