Hao. Zhu, et.al., Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies., Nature genetics, 2010, 42

http://rdf.ncbi.nlm.nih.gov/pubmed/20512147

Hao. Zhu, et.al., Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies., Nature genetics, 2010, 42

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Lin28a<tm1Egm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4849371
• Col1a1<tm1(tetO-Lin28a)Gqda>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4849370

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased litter size_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0001934I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• decreased birth weight_Lin28a<tm1Egm>/Lin28a<tm1Egm>
  http://metadb.riken.jp/0009674I129SSvEvLin28atm1EgmLin28atm1EgmLin28atm1Egm
• increased insulin sensitivity_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0002891I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• improved glucose tolerance_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0005292I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• increased hepatocyte proliferation_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0003893I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• increased body size_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0001264I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• delayed sexual maturation_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0001938I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• thick skin_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0001200I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• increased body weight_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0001260I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• delayed vaginal opening_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0002636I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• abnormal digestive system morphology_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0000462I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• premature death_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• increased body length_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0001257I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• delayed female fertility_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0008976I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• abnormal skeleton morphology_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0005508I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• coarse hair_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0002832I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• decreased circulating insulin level_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0002727I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• big ears_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0000017I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• increased bone mineral density_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0000062I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• increased growth rate_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0002865I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• decreased circulating glucose level_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0005560I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• abnormal facial morphology_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0003743I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• skin hyperplasia_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0001214I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• small pancreatic islets_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0009172I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• liver hyperplasia_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0005141I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• postnatal lethality, complete penetrance_Lin28a<tm1Egm>/Lin28a<tm1Egm>
  http://metadb.riken.jp/0011085I129SSvEvLin28atm1EgmLin28atm1EgmLin28atm1Egm
• increased cell proliferation_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0000351I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1

class

http://purl.org/net/cito/citesAsAuthority

• Lin28a<tm1Egm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4849371
• Col1a1<tm1(tetO-Lin28a)Gqda>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4849370

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD30076
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD30076