Ann. Mullally, et.al., Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells., Cancer cell, 2010, 17

http://rdf.ncbi.nlm.nih.gov/pubmed/20541703

Ann. Mullally, et.al., Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells., Cancer cell, 2010, 17

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Jak2<tm1.1Ble>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4818800
• Jak2<tm1.2Ble>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4818801

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal spleen red pulp morphology_Jak2<tm1.2Ble>/Jak2<+>
  http://metadb.riken.jp/0002356I129S6SvEvTacC57BL6FVBNJak2tm12BleJak2Jak2tm12BleJak2
• abnormal definitive hematopoiesis_Jak2<tm1.2Ble>/Jak2<+>
  http://metadb.riken.jp/0002123I129S6SvEvTacC57BL6FVBNJak2tm12BleJak2Jak2tm12BleJak2
• increased megakaryocyte cell number_Jak2<tm1.2Ble>/Jak2<+>
  http://metadb.riken.jp/0008254I129S6SvEvTacC57BL6FVBNJak2tm12BleJak2Jak2tm12BleJak2
• enhanced megakaryocyte emperipolesis_Jak2<tm1.2Ble>/Jak2<+>
  http://metadb.riken.jp/0020399I129S6SvEvTacC57BL6FVBNJak2tm12BleJak2Jak2tm12BleJak2
• prenatal lethality, complete penetrance_Jak2<tm1.2Ble>/Jak2<tm1.2Ble>
  http://metadb.riken.jp/0011091I129S6SvEvTacC57BL6FVBNJak2tm12BleJak2tm12BleJak2tm12Ble
• increased leukocyte cell number_Jak2<tm1.2Ble>/Jak2<+>
  http://metadb.riken.jp/0000218I129S6SvEvTacC57BL6FVBNJak2tm12BleJak2Jak2tm12BleJak2
• extramedullary hematopoiesis_Jak2<tm1.2Ble>/Jak2<+>
  http://metadb.riken.jp/0000240I129S6SvEvTacC57BL6FVBNJak2tm12BleJak2Jak2tm12BleJak2
• enlarged spleen_Jak2<tm1.2Ble>/Jak2<+>
  http://metadb.riken.jp/0000691I129S6SvEvTacC57BL6FVBNJak2tm12BleJak2Jak2tm12BleJak2
• increased hematocrit_Jak2<tm1.2Ble>/Jak2<+>
  http://metadb.riken.jp/0002608I129S6SvEvTacC57BL6FVBNJak2tm12BleJak2Jak2tm12BleJak2
• prenatal lethality, complete penetrance_Jak2<tm1.1Ble>/Jak2<tm1.1Ble>
  http://metadb.riken.jp/0011091I129S6SvEvTacC57BL6Jak2tm11BleJak2tm11BleJak2tm11Ble
• abnormal erythropoiesis_Jak2<tm1.2Ble>/Jak2<+>
  http://metadb.riken.jp/0000245I129S6SvEvTacC57BL6FVBNJak2tm12BleJak2Jak2tm12BleJak2
• abnormal megakaryocyte morphology_Jak2<tm1.2Ble>/Jak2<+>
  http://metadb.riken.jp/0002417I129S6SvEvTacC57BL6FVBNJak2tm12BleJak2Jak2tm12BleJak2
• increased hemolymphoid system tumor incidence_Jak2<tm1.2Ble>/Jak2<+>
  http://metadb.riken.jp/0010296I129S6SvEvTacC57BL6FVBNJak2tm12BleJak2Jak2tm12BleJak2
• premature death_Jak2<tm1.2Ble>/Jak2<+>
  http://metadb.riken.jp/0002083I129S6SvEvTacC57BL6FVBNJak2tm12BleJak2Jak2tm12BleJak2
• increased erythroid progenitor cell number_Jak2<tm1.2Ble>/Jak2<+>
  http://metadb.riken.jp/0003135I129S6SvEvTacC57BL6FVBNJak2tm12BleJak2Jak2tm12BleJak2
• abnormal spleen morphology_Jak2<tm1.2Ble>/Jak2<+>
  http://metadb.riken.jp/0000689I129S6SvEvTacC57BL6FVBNJak2tm12BleJak2Jak2tm12BleJak2
• abnormal hematopoietic system physiology_Jak2<tm1.2Ble>/Jak2<+>
  http://metadb.riken.jp/0001545I129S6SvEvTacC57BL6FVBNJak2tm12BleJak2Jak2tm12BleJak2

class

http://purl.org/net/cito/citesAsAuthority

• Jak2<tm1.1Ble>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4818800
• Jak2<tm1.2Ble>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4818801