Po-Min. Chiang, et.al., Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107

http://rdf.ncbi.nlm.nih.gov/pubmed/20660762

Po-Min. Chiang, et.al., Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tardbp<tm1.2Pcw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4834280
• Tardbp<tm1.1Pcw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4834273

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal brown fat cell morphology_Tardbp<tm1.1Pcw>/Tardbp<+>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0009116I129C57BL6CBASJLTardbptm11PcwTardbpTgCAGcreEsr15Amc0TardbpTgCAGcreEsr15AmcTardbptm11Pcw
• abnormal respiratory quotient_Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>,Tardbp<tm1.1Pcw>/Tardbp<+>
  http://metadb.riken.jp/0004129I129C57BL6SJLGtROSA26Sortm1creERTNatGtROSA26SorTardbptm11PcwTardbpGtROSA26SorGtROSA26Sortm1creERTNatTardbpTardbptm11Pcw
• abnormal white fat cell morphology_Tardbp<tm1.1Pcw>/Tardbp<+>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0009117I129C57BL6CBASJLTardbptm11PcwTardbpTgCAGcreEsr15Amc0TardbpTgCAGcreEsr15AmcTardbptm11Pcw
• abnormal brown fat cell morphology_Tardbp<tm1.1Pcw>/Tardbp<tm1.1Pcw>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0009116I129C57BL6CBASJLTardbptm11PcwTardbptm11PcwTgCAGcreEsr15Amc0Tardbptm11PcwTgCAGcreEsr15Amc
• abnormal respiratory quotient_Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>,Tardbp<tm1.1Pcw>/Tardbp<tm1.1Pcw>
  http://metadb.riken.jp/0004129I129C57BL6SJLGtROSA26Sortm1creERTNatGtROSA26SorTardbptm11PcwTardbptm11PcwGtROSA26Sortm1creERTNatGtROSA26SorTardbptm11Pcw
• abnormal lipid oxidation_Tardbp<tm1.1Pcw>/Tardbp<tm1.1Pcw>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0010951I129C57BL6CBASJLTardbptm11PcwTardbptm11PcwTgCAGcreEsr15Amc0Tardbptm11PcwTgCAGcreEsr15Amc
• abnormal lipid oxidation_Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>,Tardbp<tm1.1Pcw>/Tardbp<tm1.1Pcw>
  http://metadb.riken.jp/0010951I129C57BL6SJLGtROSA26Sortm1creERTNatGtROSA26SorTardbptm11PcwTardbptm11PcwGtROSA26Sortm1creERTNatGtROSA26SorTardbptm11Pcw
• decreased body weight_Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>,Tardbp<tm1.1Pcw>/Tardbp<tm1.1Pcw>
  http://metadb.riken.jp/0001262I129C57BL6SJLGtROSA26Sortm1creERTNatGtROSA26SorTardbptm11PcwTardbptm11PcwGtROSA26Sortm1creERTNatGtROSA26SorTardbptm11Pcw
• prenatal lethality, complete penetrance_Tardbp<tm1.2Pcw>/Tardbp<tm1.2Pcw>
  http://metadb.riken.jp/0011091IC57BL6SJLTardbptm12PcwTardbptm12PcwTardbptm12Pcw
• abnormal survival_Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>,Tardbp<tm1.1Pcw>/Tardbp<tm1.1Pcw>
  http://metadb.riken.jp/0010769I129C57BL6SJLGtROSA26Sortm1creERTNatGtROSA26SorTardbptm11PcwTardbptm11PcwGtROSA26Sortm1creERTNatGtROSA26SorTardbptm11Pcw
• weight loss_Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>,Tardbp<tm1.1Pcw>/Tardbp<tm1.1Pcw>
  http://metadb.riken.jp/0001263I129C57BL6SJLGtROSA26Sortm1creERTNatGtROSA26SorTardbptm11PcwTardbptm11PcwGtROSA26Sortm1creERTNatGtROSA26SorTardbptm11Pcw
• decreased total body fat amount_Tardbp<tm1.1Pcw>/Tardbp<tm1.1Pcw>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0010025I129C57BL6CBASJLTardbptm11PcwTardbptm11PcwTgCAGcreEsr15Amc0Tardbptm11PcwTgCAGcreEsr15Amc
• decreased body weight_Tardbp<tm1.1Pcw>/Tardbp<tm1.1Pcw>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0001262I129C57BL6CBASJLTardbptm11PcwTardbptm11PcwTgCAGcreEsr15Amc0Tardbptm11PcwTgCAGcreEsr15Amc
• decreased body weight_Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>,Tardbp<tm1.1Pcw>/Tardbp<+>
  http://metadb.riken.jp/0001262I129C57BL6SJLGtROSA26Sortm1creERTNatGtROSA26SorTardbptm11PcwTardbpGtROSA26SorGtROSA26Sortm1creERTNatTardbpTardbptm11Pcw
• abnormal food intake_Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>,Tardbp<tm1.1Pcw>/Tardbp<tm1.1Pcw>
  http://metadb.riken.jp/0005449I129C57BL6SJLGtROSA26Sortm1creERTNatGtROSA26SorTardbptm11PcwTardbptm11PcwGtROSA26Sortm1creERTNatGtROSA26SorTardbptm11Pcw
• abnormal white fat cell morphology_Tardbp<tm1.1Pcw>/Tardbp<tm1.1Pcw>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0009117I129C57BL6CBASJLTardbptm11PcwTardbptm11PcwTgCAGcreEsr15Amc0Tardbptm11PcwTgCAGcreEsr15Amc
• decreased body weight_Tardbp<tm1.1Pcw>/Tardbp<+>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0001262I129C57BL6CBASJLTardbptm11PcwTardbpTgCAGcreEsr15Amc0TardbpTgCAGcreEsr15AmcTardbptm11Pcw
• abnormal white adipose tissue morphology_Tardbp<tm1.1Pcw>/Tardbp<tm1.1Pcw>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0002970I129C57BL6CBASJLTardbptm11PcwTardbptm11PcwTgCAGcreEsr15Amc0Tardbptm11PcwTgCAGcreEsr15Amc
• decreased mesenteric fat pad weight_Tardbp<tm1.1Pcw>/Tardbp<tm1.1Pcw>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0009299I129C57BL6CBASJLTardbptm11PcwTardbptm11PcwTgCAGcreEsr15Amc0Tardbptm11PcwTgCAGcreEsr15Amc
• decreased total body fat amount_Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>,Tardbp<tm1.1Pcw>/Tardbp<tm1.1Pcw>
  http://metadb.riken.jp/0010025I129C57BL6SJLGtROSA26Sortm1creERTNatGtROSA26SorTardbptm11PcwTardbptm11PcwGtROSA26Sortm1creERTNatGtROSA26SorTardbptm11Pcw
• decreased total body fat amount_Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>,Tardbp<tm1.1Pcw>/Tardbp<+>
  http://metadb.riken.jp/0010025I129C57BL6SJLGtROSA26Sortm1creERTNatGtROSA26SorTardbptm11PcwTardbpGtROSA26SorGtROSA26Sortm1creERTNatTardbpTardbptm11Pcw

class

http://purl.org/net/cito/citesAsAuthority

• Tardbp<tm1.2Pcw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4834280
• Tardbp<tm1.1Pcw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4834273

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD05079
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD05079
• CD02137
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02137