Christopher R. Heier, et.al., Arrhythmia and cardiac defects are a feature of spinal muscular atrophy model mice., Human molecular genetics, 2010, 19

http://rdf.ncbi.nlm.nih.gov/pubmed/20693262

Christopher R. Heier, et.al., Arrhythmia and cardiac defects are a feature of spinal muscular atrophy model mice., Human molecular genetics, 2010, 19

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal heart morphology_Smn1<tm1Msd>/Smn1<tm1Msd>,Grm7<Tg(SMN2)89Ahmb>/Grm7<Tg(SMN2)89Ahmb>,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
  http://metadb.riken.jp/0000266FVBCgGrm7TgSMN289AhmbSmn1tm1MsdTgSMN2delta74299AhmbJSmn1tm1MsdSmn1tm1MsdGrm7TgSMN289AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbTgSMN2delta74299AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbSmn1tm1Msd
• prolonged PR interval_Smn1<tm1Msd>/Smn1<tm1Msd>,Grm7<Tg(SMN2)89Ahmb>/Grm7<Tg(SMN2)89Ahmb>,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
  http://metadb.riken.jp/0003896FVBCgGrm7TgSMN289AhmbSmn1tm1MsdTgSMN2delta74299AhmbJSmn1tm1MsdSmn1tm1MsdGrm7TgSMN289AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbTgSMN2delta74299AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbSmn1tm1Msd
• increased heart rate variability_Smn1<tm1Msd>/Smn1<tm1Msd>,Grm7<Tg(SMN2)89Ahmb>/Grm7<Tg(SMN2)89Ahmb>,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
  http://metadb.riken.jp/0003928FVBCgGrm7TgSMN289AhmbSmn1tm1MsdTgSMN2delta74299AhmbJSmn1tm1MsdSmn1tm1MsdGrm7TgSMN289AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbTgSMN2delta74299AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbSmn1tm1Msd
• dilated cardiomyopathy_Smn1<tm1Msd>/Smn1<tm1Msd>,Grm7<Tg(SMN2)89Ahmb>/Grm7<Tg(SMN2)89Ahmb>,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
  http://metadb.riken.jp/0002795FVBCgGrm7TgSMN289AhmbSmn1tm1MsdTgSMN2delta74299AhmbJSmn1tm1MsdSmn1tm1MsdGrm7TgSMN289AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbTgSMN2delta74299AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbSmn1tm1Msd
• decreased heart rate_Smn1<tm1Msd>/Smn1<tm1Msd>,Grm7<Tg(SMN2)89Ahmb>/Grm7<Tg(SMN2)89Ahmb>,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
  http://metadb.riken.jp/0005333FVBCgGrm7TgSMN289AhmbSmn1tm1MsdTgSMN2delta74299AhmbJSmn1tm1MsdSmn1tm1MsdGrm7TgSMN289AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbTgSMN2delta74299AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbSmn1tm1Msd
• prolonged QRS complex duration_Smn1<tm1Msd>/Smn1<tm1Msd>,Grm7<Tg(SMN2)89Ahmb>/Grm7<Tg(SMN2)89Ahmb>,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
  http://metadb.riken.jp/0010392FVBCgGrm7TgSMN289AhmbSmn1tm1MsdTgSMN2delta74299AhmbJSmn1tm1MsdSmn1tm1MsdGrm7TgSMN289AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbTgSMN2delta74299AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbSmn1tm1Msd
• abnormal blood flow velocity_Smn1<tm1Msd>/Smn1<tm1Msd>,Grm7<Tg(SMN2)89Ahmb>/Grm7<Tg(SMN2)89Ahmb>,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
  http://metadb.riken.jp/0000233FVBCgGrm7TgSMN289AhmbSmn1tm1MsdTgSMN2delta74299AhmbJSmn1tm1MsdSmn1tm1MsdGrm7TgSMN289AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbTgSMN2delta74299AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbSmn1tm1Msd
• weight loss_Smn1<tm1Msd>/Smn1<tm1Msd>,Grm7<Tg(SMN2)89Ahmb>/Grm7<Tg(SMN2)89Ahmb>,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
  http://metadb.riken.jp/0001263FVBCgGrm7TgSMN289AhmbSmn1tm1MsdTgSMN2delta74299AhmbJSmn1tm1MsdSmn1tm1MsdGrm7TgSMN289AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbTgSMN2delta74299AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbSmn1tm1Msd
• abnormal sympathetic system morphology_Smn1<tm1Msd>/Smn1<tm1Msd>,Grm7<Tg(SMN2)89Ahmb>/Grm7<Tg(SMN2)89Ahmb>,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
  http://metadb.riken.jp/0001007FVBCgGrm7TgSMN289AhmbSmn1tm1MsdTgSMN2delta74299AhmbJSmn1tm1MsdSmn1tm1MsdGrm7TgSMN289AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbTgSMN2delta74299AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbSmn1tm1Msd
• postnatal lethality, complete penetrance_Smn1<tm1Msd>/Smn1<tm1Msd>,Grm7<Tg(SMN2)89Ahmb>/Grm7<Tg(SMN2)89Ahmb>,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
  http://metadb.riken.jp/0011085FVBCgGrm7TgSMN289AhmbSmn1tm1MsdTgSMN2delta74299AhmbJSmn1tm1MsdSmn1tm1MsdGrm7TgSMN289AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbTgSMN2delta74299AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbSmn1tm1Msd
• decreased body size_Smn1<tm1Msd>/Smn1<tm1Msd>,Grm7<Tg(SMN2)89Ahmb>/Grm7<Tg(SMN2)89Ahmb>,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
  http://metadb.riken.jp/0001265FVBCgGrm7TgSMN289AhmbSmn1tm1MsdTgSMN2delta74299AhmbJSmn1tm1MsdSmn1tm1MsdGrm7TgSMN289AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbTgSMN2delta74299AhmbGrm7TgSMN289AhmbTgSMN2delta74299AhmbSmn1tm1Msd