Ya-Fei. Xu, et.al., Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, 30

http://rdf.ncbi.nlm.nih.gov/pubmed/20702714

Ya-Fei. Xu, et.al., Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, 30

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp-TARDBP)3cPtrc
  http://metadb.riken.jp/db/mgi_rdf/MGI:5002476

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp-TARDBP)3cPtrc
  http://metadb.riken.jp/db/mgi_rdf/MGI:5002476

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased body weight_Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc
  http://metadb.riken.jp/0001262C57BL6TgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrc
• abnormal gait_Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc
  http://metadb.riken.jp/0001406C57BL6TgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrc
• abnormal red nucleus morphology_Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc
  http://metadb.riken.jp/0012267C57BL6TgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrc
• abnormal brainstem morphology_Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc
  http://metadb.riken.jp/0005277C57BL6TgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrc
• decreased brain weight_Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc
  http://metadb.riken.jp/0002175C57BL6TgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrc
• abnormal spinal cord white matter morphology_Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc
  http://metadb.riken.jp/0008027C57BL6TgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrc
• tremors_Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc
  http://metadb.riken.jp/0000745C57BL6TgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrc
• limb grasping_Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc
  http://metadb.riken.jp/0001513C57BL6TgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrc
• demyelination_Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc
  http://metadb.riken.jp/0000921C57BL6TgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrc
• impaired righting response_Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc
  http://metadb.riken.jp/0001523C57BL6TgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrc
• neuron degeneration_Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc
  http://metadb.riken.jp/0003224C57BL6TgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrc
• astrocytosis_Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc
  http://metadb.riken.jp/0003354C57BL6TgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrc
• premature death_Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc
  http://metadb.riken.jp/0002083C57BL6TgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrc
• gliosis_Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc
  http://metadb.riken.jp/0002183C57BL6TgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrc
• abnormal motor neuron morphology_Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc
  http://metadb.riken.jp/0000937C57BL6TgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrc
• axon degeneration_Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc
  http://metadb.riken.jp/0005405C57BL6TgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrcTgPrnpTARDBP3cPtrc