Elizabeth A. Hurd, et.al., The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear., Development (Cambridge, England), 2010, 137

http://rdf.ncbi.nlm.nih.gov/pubmed/20736290

Elizabeth A. Hurd, et.al., The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear., Development (Cambridge, England), 2010, 137

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Chd7<tm1.1Dmm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4835266
• Chd7<tm1.2Dmm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4835268

class

http://purl.org/net/cito/citesAsAuthority

• Chd7<tm1.1Dmm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4835266
• Chd7<tm1.2Dmm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4835268

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal ear development_Chd7<tm1.1Dmm>/Chd7<+>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0003938I129C57BL6SwissWebsterChd7tm11DmmChd7Foxg1tm1creSkmFoxg1Chd7Foxg1tm1creSkmChd7tm11DmmFoxg1
• decreased cochlear coiling_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0003148I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmFoxg1tm1creSkmFoxg1Foxg1Chd7tm11DmmFoxg1tm1creSkmChd7GtS207E1Sor
• absent lateral semicircular canal_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0003161I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmFoxg1tm1creSkmFoxg1Foxg1Chd7tm11DmmFoxg1tm1creSkmChd7GtS207E1Sor
• abnormal vestibulocochlear ganglion morphology_Chd7<Gt(S20-7E1)Sor>/Chd7<+>
  http://metadb.riken.jp/0003703I129S4SvJaeSorChd7GtS207E1SorChd7Chd7GtS207E1SorChd7
• abnormal inner ear vestibule morphology_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0000034I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmFoxg1tm1creSkmFoxg1Foxg1Chd7tm11DmmFoxg1tm1creSkmChd7GtS207E1Sor
• abnormal vestibulocochlear ganglion morphology_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0003703I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmFoxg1tm1creSkmFoxg1Foxg1Chd7tm11DmmFoxg1tm1creSkmChd7GtS207E1Sor
• abnormal neuronal precursor cell number_Chd7<Gt(S20-7E1)Sor>/Chd7<+>
  http://metadb.riken.jp/0004979I129S4SvJaeSorChd7GtS207E1SorChd7Chd7GtS207E1SorChd7
• decreased superior semicircular canal size_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0003166I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmFoxg1tm1creSkmFoxg1Foxg1Chd7tm11DmmFoxg1tm1creSkmChd7GtS207E1Sor
• abnormal neuronal precursor cell number_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0004979I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmFoxg1tm1creSkmFoxg1Foxg1Chd7tm11DmmFoxg1tm1creSkmChd7GtS207E1Sor
• absent posterior semicircular canal_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0003163I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmFoxg1tm1creSkmFoxg1Foxg1Chd7tm11DmmFoxg1tm1creSkmChd7GtS207E1Sor
• ocular hypertelorism_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0001300I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmFoxg1tm1creSkmFoxg1Foxg1Chd7tm11DmmFoxg1tm1creSkmChd7GtS207E1Sor
• abnormal vestibulocochlear ganglion morphology_Chd7<Gt(S20-7E1)Sor>/Chd7<Gt(S20-7E1)Sor>
  http://metadb.riken.jp/0003703I129S4SvJaeSorChd7GtS207E1SorChd7GtS207E1SorChd7GtS207E1Sor
• abnormal vestibulocochlear ganglion morphology_Chd7<tm1.1Dmm>/Chd7<+>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0003703I129C57BL6SwissWebsterChd7tm11DmmChd7Foxg1tm1creSkmFoxg1Chd7Foxg1tm1creSkmChd7tm11DmmFoxg1
• short snout_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0000445I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmFoxg1tm1creSkmFoxg1Foxg1Chd7tm11DmmFoxg1tm1creSkmChd7GtS207E1Sor
• decreased lateral semicircular canal size_Chd7<tm1.1Dmm>/Chd7<+>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0003162I129C57BL6SwissWebsterChd7tm11DmmChd7Foxg1tm1creSkmFoxg1Chd7Foxg1tm1creSkmChd7tm11DmmFoxg1
• abnormal neuronal precursor proliferation_Chd7<Gt(S20-7E1)Sor>/Chd7<+>
  http://metadb.riken.jp/0004948I129S4SvJaeSorChd7GtS207E1SorChd7Chd7GtS207E1SorChd7
• abnormal neuronal precursor proliferation_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0004948I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmFoxg1tm1creSkmFoxg1Foxg1Chd7tm11DmmFoxg1tm1creSkmChd7GtS207E1Sor
• abnormal ear development_Chd7<Gt(S20-7E1)Sor>/Chd7<+>
  http://metadb.riken.jp/0003938I129S4SvJaeSorChd7GtS207E1SorChd7Chd7GtS207E1SorChd7
• absent vestibular saccule_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0004315I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmFoxg1tm1creSkmFoxg1Foxg1Chd7tm11DmmFoxg1tm1creSkmChd7GtS207E1Sor
• small endolymphatic duct_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0008066I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmFoxg1tm1creSkmFoxg1Foxg1Chd7tm11DmmFoxg1tm1creSkmChd7GtS207E1Sor
• abnormal ear development_Chd7<Gt(S20-7E1)Sor>/Chd7<Gt(S20-7E1)Sor>
  http://metadb.riken.jp/0003938I129S4SvJaeSorChd7GtS207E1SorChd7GtS207E1SorChd7GtS207E1Sor
• abnormal suckling behavior_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0001436I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmFoxg1tm1creSkmFoxg1Foxg1Chd7tm11DmmFoxg1tm1creSkmChd7GtS207E1Sor
• abnormal crista ampullaris morphology_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0004249I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmFoxg1tm1creSkmFoxg1Foxg1Chd7tm11DmmFoxg1tm1creSkmChd7GtS207E1Sor
• neonatal lethality, complete penetrance_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0011087I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmFoxg1tm1creSkmFoxg1Foxg1Chd7tm11DmmFoxg1tm1creSkmChd7GtS207E1Sor
• head bobbing_Chd7<tm1.2Dmm>/Chd7<tm1.2Dmm>
  http://metadb.riken.jp/0001410I129S4SvJaeSor129S6SvEvTacC57BL6FVBNChd7tm12DmmChd7tm12DmmChd7tm12Dmm
• abnormal neuronal precursor proliferation_Chd7<Gt(S20-7E1)Sor>/Chd7<Gt(S20-7E1)Sor>
  http://metadb.riken.jp/0004948I129S4SvJaeSorChd7GtS207E1SorChd7GtS207E1SorChd7GtS207E1Sor
• circling_Chd7<tm1.2Dmm>/Chd7<tm1.2Dmm>
  http://metadb.riken.jp/0001394I129S4SvJaeSor129S6SvEvTacC57BL6FVBNChd7tm12DmmChd7tm12DmmChd7tm12Dmm
• abnormal cochlea morphology_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0000031I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmFoxg1tm1creSkmFoxg1Foxg1Chd7tm11DmmFoxg1tm1creSkmChd7GtS207E1Sor
• decreased lateral semicircular canal size_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>
  http://metadb.riken.jp/0003162I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmChd7GtS207E1SorChd7tm11Dmm
• absent utricle_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0004369I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmFoxg1tm1creSkmFoxg1Foxg1Chd7tm11DmmFoxg1tm1creSkmChd7GtS207E1Sor
• abnormal neuronal precursor cell number_Chd7<Gt(S20-7E1)Sor>/Chd7<Gt(S20-7E1)Sor>
  http://metadb.riken.jp/0004979I129S4SvJaeSorChd7GtS207E1SorChd7GtS207E1SorChd7GtS207E1Sor
• abnormal semicircular canal morphology_Chd7<tm1.2Dmm>/Chd7<tm1.2Dmm>
  http://metadb.riken.jp/0002428I129S4SvJaeSor129S6SvEvTacC57BL6FVBNChd7tm12DmmChd7tm12DmmChd7tm12Dmm
• abnormal ear development_Chd7<Gt(S20-7E1)Sor>/Chd7<tm1.1Dmm>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0003938I129C57BL6SwissWebsterChd7GtS207E1SorChd7tm11DmmFoxg1tm1creSkmFoxg1Foxg1Chd7tm11DmmFoxg1tm1creSkmChd7GtS207E1Sor

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD02185
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02185
• CD40916
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD40916