Peng-Chieh. Chen, et.al., Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation., The Journal of clinical investigation, 2010, 120

http://rdf.ncbi.nlm.nih.gov/pubmed/21041952

Peng-Chieh. Chen, et.al., Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation., The Journal of clinical investigation, 2010, 120

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Sos1<tm1.2Rak>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5000290

class

http://purl.org/net/cito/citesAsAuthority

• Sos1<tm1.2Rak>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5000290

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hemorrhage_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0001914I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• abnormal common myeloid progenitor cell morphology_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0006410I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• thick interventricular septum_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0010724I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• abnormal frontal bone morphology_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0000107I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• decreased body weight_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0001262I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• enlarged spleen_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0000691I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• embryonic lethality during organogenesis, incomplete penetrance_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0011108I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• aortic valve stenosis_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0006117I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• hemorrhage_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0001914I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• ventricular septal defect_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0010402I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• thick aortic valve cusps_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0010593I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• decreased cranium height_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0008525I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• thick interventricular septum_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0010724I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• decreased body size_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0001265I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• thick aortic valve cusps_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0010593I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• heart right ventricle hypertrophy_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0000276I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• extramedullary hematopoiesis_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0000240I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• ocular hypertelorism_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0001300I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• ostium secundum atrial septal defect_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0010405I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• cardiac fibrosis_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0003141I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• abnormal frontal bone morphology_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0000107I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• lethality throughout fetal growth and development, incomplete penetrance_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0011109I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• increased spleen red pulp amount_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0008476I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• abnormal craniofacial morphology_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0000428I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• cardiac interstitial fibrosis_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0005608I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• increased cardiomyocyte apoptosis_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0003222I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• abnormal heart left ventricle morphology_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0003921I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• decreased body length_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0001258I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• abnormal erythropoiesis_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0000245I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• decreased body weight_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0001262I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• decreased cranium height_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0008525I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• increased leukocyte cell number_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0000218I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• myocardial fiber degeneration_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0004566I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• enlarged myocardial fiber_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0004564I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• abnormal cardiovascular system physiology_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0001544I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• heart left ventricle hypertrophy_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0002625I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• premature death_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0002083I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• decreased body length_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0001258I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• decreased body size_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0001265I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• abnormal cardiovascular system physiology_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0001544I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• skin edema_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0001786I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• abnormal myocardial fiber morphology_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0000278I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• increased megakaryocyte cell number_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0008254I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• skin edema_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0001786I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• aortic valve stenosis_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0006117I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• pericardial effusion_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0005312I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• abnormal fetal cardiomyocyte proliferation_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0003567I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak
• abnormal craniofacial morphology_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0000428I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• pericardial effusion_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0005312I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• cardiac fibrosis_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0003141I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• ocular hypertelorism_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0001300I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• increased neutrophil cell number_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0000219I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• abnormal fetal cardiomyocyte proliferation_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0003567I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• abnormal heart morphology_Sos1<tm1.2Rak>/Sos1<+>
  http://metadb.riken.jp/0000266I129SSvC57BL6FVBNSJLSos1tm12RakSos1Sos1Sos1tm12Rak
• abnormal heart morphology_Sos1<tm1.2Rak>/Sos1<tm1.2Rak>
  http://metadb.riken.jp/0000266I129SSvC57BL6FVBNSJLSos1tm12RakSos1tm12RakSos1tm12Rak

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD28014
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD28014