Alexander. Gerbaulet, et.al., Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit., Blood, 2011, 117

http://rdf.ncbi.nlm.nih.gov/pubmed/21148330

Alexander. Gerbaulet, et.al., Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit., Blood, 2011, 117

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Kit*D814V)3Roer
  http://metadb.riken.jp/db/mgi_rdf/MGI:4942359
• Tg(Kit*D814V)1Roer
  http://metadb.riken.jp/db/mgi_rdf/MGI:4942357
• Tg(Kit*D814V)2Roer
  http://metadb.riken.jp/db/mgi_rdf/MGI:4942358

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Kit*D814V)3Roer
  http://metadb.riken.jp/db/mgi_rdf/MGI:4942359
• Tg(Kit*D814V)1Roer
  http://metadb.riken.jp/db/mgi_rdf/MGI:4942357
• Tg(Kit*D814V)2Roer
  http://metadb.riken.jp/db/mgi_rdf/MGI:4942358

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal mast cell morphology_Tg(Kit*D814V)2Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000359IC57BL6CBATgKitD814V2Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V2Roer
• premature death_Tg(Kit*D814V)3Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083IC57BL6CBATgKitD814V3Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V3Roer
• abnormal bone marrow cell physiology_Tg(Kit*D814V)3Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0009278IC57BL6CBATgKitD814V3Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V3Roer
• weight loss_Tg(Kit*D814V)2Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001263IC57BL6CBATgKitD814V2Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V2Roer
• large intestinal inflammation_Tg(Kit*D814V)3Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003304IC57BL6CBATgKitD814V3Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V3Roer
• increased skin tumor incidence_Tg(Kit*D814V)2Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0010300IC57BL6CBATgKitD814V2Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V2Roer
• abnormal erythrocyte physiology_Tg(CMV-cre)1Cgn/0,Tg(Kit*D814V)1Roer/0
  http://metadb.riken.jp/0003656IBALBcJC57BL6TgCMVcre1Cgn0TgKitD814V1Roer0TgKitD814V1RoerTgCMVcre1Cgn
• abnormal bone marrow cell physiology_Tg(Kit*D814V)2Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0009278IC57BL6CBATgKitD814V2Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V2Roer
• abnormal bone marrow cell physiology_Tg(Kit*D814V)1Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0009278IC57BL6CBATgKitD814V1Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V1Roer
• neonatal lethality, incomplete penetrance_Tg(CMV-cre)1Cgn/0,Tg(Kit*D814V)1Roer/0
  http://metadb.riken.jp/0011088IBALBcJC57BL6TgCMVcre1Cgn0TgKitD814V1Roer0TgKitD814V1RoerTgCMVcre1Cgn
• premature death_Tg(Kit*D814V)1Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083IC57BL6CBATgKitD814V1Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V1Roer
• neonatal lethality_Tg(Kit*D814V)3Roer/0,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0002058IC57BL6C57BL10CBACaTgKitD814V3Roer0TgVav1icreA2Kio0TgVav1icreA2KioTgKitD814V3Roer
• abnormal liver morphology_Tg(CMV-cre)1Cgn/0,Tg(Kit*D814V)3Roer/0
  http://metadb.riken.jp/0000598IBALBcJC57BL6TgCMVcre1Cgn0TgKitD814V3Roer0TgCMVcre1CgnTgKitD814V3Roer
• increased mast cell number_Tg(Kit*D814V)1Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000324IC57BL6CBATgKitD814V1Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V1Roer
• weight loss_Tg(Kit*D814V)3Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001263IC57BL6CBATgKitD814V3Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V3Roer
• neonatal lethality, incomplete penetrance_Tg(CMV-cre)1Cgn/0,Tg(Kit*D814V)3Roer/0
  http://metadb.riken.jp/0011088IBALBcJC57BL6TgCMVcre1Cgn0TgKitD814V3Roer0TgCMVcre1CgnTgKitD814V3Roer
• increased skin tumor incidence_Tg(Cma1-cre)ARoer/0,Tg(Kit*D814V)1Roer/0
  http://metadb.riken.jp/0010300IC57BL6TgCma1creARoer0TgKitD814V1Roer0TgCma1creARoerTgKitD814V1Roer
• decreased survivor rate_Tg(CMV-cre)1Cgn/0,Tg(Kit*D814V)1Roer/0
  http://metadb.riken.jp/0008770IBALBcJC57BL6TgCMVcre1Cgn0TgKitD814V1Roer0TgKitD814V1RoerTgCMVcre1Cgn
• increased leukemia incidence_Tg(Kit*D814V)1Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002026IC57BL6CBATgKitD814V1Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V1Roer
• increased nucleated erythrocyte cell number_Tg(CMV-cre)1Cgn/0,Tg(Kit*D814V)3Roer/0
  http://metadb.riken.jp/0009395IBALBcJC57BL6TgCMVcre1Cgn0TgKitD814V3Roer0TgCMVcre1CgnTgKitD814V3Roer
• increased skin tumor incidence_Tg(Cma1-cre)ARoer/0,Tg(Kit*D814V)3Roer/0
  http://metadb.riken.jp/0010300IC57BL6TgCma1creARoer0TgKitD814V3Roer0TgKitD814V3RoerTgCma1creARoer
• colitis_Tg(Kit*D814V)2Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002816IC57BL6CBATgKitD814V2Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V2Roer
• rectal prolapse_Tg(Kit*D814V)2Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000493IC57BL6CBATgKitD814V2Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V2Roer
• abnormal feces composition_Tg(Kit*D814V)3Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003868IC57BL6CBATgKitD814V3Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V3Roer
• abnormal mast cell morphology_Tg(Kit*D814V)1Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000359IC57BL6CBATgKitD814V1Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V1Roer
• colitis_Tg(Kit*D814V)3Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002816IC57BL6CBATgKitD814V3Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V3Roer
• small intestinal inflammation_Tg(Kit*D814V)1Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003306IC57BL6CBATgKitD814V1Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V1Roer
• increased mast cell number_Tg(Cma1-cre)ARoer/0,Tg(Kit*D814V)1Roer/0
  http://metadb.riken.jp/0000324IC57BL6TgCma1creARoer0TgKitD814V1Roer0TgCma1creARoerTgKitD814V1Roer
• colitis_Tg(Kit*D814V)1Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002816IC57BL6CBATgKitD814V1Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V1Roer
• increased chronic myelocytic leukemia incidence_Tg(Kit*D814V)1Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005481IC57BL6CBATgKitD814V1Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V1Roer
• rectal prolapse_Tg(Kit*D814V)1Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000493IC57BL6CBATgKitD814V1Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V1Roer
• diarrhea_Tg(Kit*D814V)3Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005036IC57BL6CBATgKitD814V3Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V3Roer
• abnormal erythropoiesis_Tg(CMV-cre)1Cgn/0,Tg(Kit*D814V)1Roer/0
  http://metadb.riken.jp/0000245IBALBcJC57BL6TgCMVcre1Cgn0TgKitD814V1Roer0TgKitD814V1RoerTgCMVcre1Cgn
• crypts of Lieberkuhn abscesses_Tg(Kit*D814V)1Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000491IC57BL6CBATgKitD814V1Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V1Roer
• neonatal lethality_Tg(Kit*D814V)1Roer/0,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0002058IC57BL6C57BL10CBACaTgKitD814V1Roer0TgVav1icreA2Kio0TgVav1icreA2KioTgKitD814V1Roer
• increased mast cell number_Tg(CMV-cre)1Cgn/0,Tg(Kit*D814V)3Roer/0
  http://metadb.riken.jp/0000324IBALBcJC57BL6TgCMVcre1Cgn0TgKitD814V3Roer0TgCMVcre1CgnTgKitD814V3Roer
• abnormal erythrocyte physiology_Tg(CMV-cre)1Cgn/0,Tg(Kit*D814V)3Roer/0
  http://metadb.riken.jp/0003656IBALBcJC57BL6TgCMVcre1Cgn0TgKitD814V3Roer0TgCMVcre1CgnTgKitD814V3Roer
• increased leukemia incidence_Tg(Kit*D814V)3Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002026IC57BL6CBATgKitD814V3Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V3Roer
• large intestinal inflammation_Tg(CMV-cre)1Cgn/0,Tg(Kit*D814V)1Roer/0
  http://metadb.riken.jp/0003304IBALBcJC57BL6TgCMVcre1Cgn0TgKitD814V1Roer0TgKitD814V1RoerTgCMVcre1Cgn
• rectal prolapse_Tg(Kit*D814V)3Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000493IC57BL6CBATgKitD814V3Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V3Roer
• large intestinal inflammation_Tg(Kit*D814V)2Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003304IC57BL6CBATgKitD814V2Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V2Roer
• increased mast cell number_Tg(CMV-cre)1Cgn/0,Tg(Kit*D814V)1Roer/0
  http://metadb.riken.jp/0000324IBALBcJC57BL6TgCMVcre1Cgn0TgKitD814V1Roer0TgKitD814V1RoerTgCMVcre1Cgn
• increased mast cell number_Tg(Kit*D814V)3Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000324IC57BL6CBATgKitD814V3Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V3Roer
• colitis_Tg(Cma1-cre)ARoer/0,Tg(Kit*D814V)1Roer/0
  http://metadb.riken.jp/0002816IC57BL6TgCma1creARoer0TgKitD814V1Roer0TgCma1creARoerTgKitD814V1Roer
• large intestinal inflammation_Tg(Kit*D814V)1Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003304IC57BL6CBATgKitD814V1Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V1Roer
• increased skin tumor incidence_Tg(Kit*D814V)1Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0010300IC57BL6CBATgKitD814V1Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V1Roer
• abnormal large intestine morphology_Tg(Kit*D814V)1Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000489IC57BL6CBATgKitD814V1Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V1Roer
• diarrhea_Tg(Kit*D814V)2Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005036IC57BL6CBATgKitD814V2Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V2Roer
• increased skin tumor incidence_Tg(Kit*D814V)3Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0010300IC57BL6CBATgKitD814V3Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V3Roer
• abnormal liver morphology_Tg(CMV-cre)1Cgn/0,Tg(Kit*D814V)1Roer/0
  http://metadb.riken.jp/0000598IBALBcJC57BL6TgCMVcre1Cgn0TgKitD814V1Roer0TgKitD814V1RoerTgCMVcre1Cgn
• enlarged spleen_Tg(Kit*D814V)3Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691IC57BL6CBATgKitD814V3Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V3Roer
• abnormal erythropoiesis_Tg(CMV-cre)1Cgn/0,Tg(Kit*D814V)3Roer/0
  http://metadb.riken.jp/0000245IBALBcJC57BL6TgCMVcre1Cgn0TgKitD814V3Roer0TgCMVcre1CgnTgKitD814V3Roer
• decreased survivor rate_Tg(CMV-cre)1Cgn/0,Tg(Kit*D814V)3Roer/0
  http://metadb.riken.jp/0008770IBALBcJC57BL6TgCMVcre1Cgn0TgKitD814V3Roer0TgCMVcre1CgnTgKitD814V3Roer
• small intestinal inflammation_Tg(Kit*D814V)2Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003306IC57BL6CBATgKitD814V2Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V2Roer
• increased nucleated erythrocyte cell number_Tg(CMV-cre)1Cgn/0,Tg(Kit*D814V)1Roer/0
  http://metadb.riken.jp/0009395IBALBcJC57BL6TgCMVcre1Cgn0TgKitD814V1Roer0TgKitD814V1RoerTgCMVcre1Cgn
• increased mast cell number_Tg(Cma1-cre)ARoer/0,Tg(Kit*D814V)3Roer/0
  http://metadb.riken.jp/0000324IC57BL6TgCma1creARoer0TgKitD814V3Roer0TgKitD814V3RoerTgCma1creARoer
• crypts of Lieberkuhn abscesses_Tg(Kit*D814V)2Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000491IC57BL6CBATgKitD814V2Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V2Roer
• weight loss_Tg(Kit*D814V)1Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001263IC57BL6CBATgKitD814V1Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V1Roer
• abnormal large intestine morphology_Tg(Kit*D814V)2Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000489IC57BL6CBATgKitD814V2Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V2Roer
• abnormal mast cell morphology_Tg(Kit*D814V)3Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000359IC57BL6CBATgKitD814V3Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V3Roer
• enlarged spleen_Tg(Kit*D814V)1Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691IC57BL6CBATgKitD814V1Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V1Roer
• abnormal feces composition_Tg(Kit*D814V)2Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003868IC57BL6CBATgKitD814V2Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V2Roer
• increased mast cell number_Tg(Kit*D814V)2Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000324IC57BL6CBATgKitD814V2Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V2Roer
• abnormal feces composition_Tg(Kit*D814V)1Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003868IC57BL6CBATgKitD814V1Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V1Roer
• diarrhea_Tg(Kit*D814V)1Roer/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005036IC57BL6CBATgKitD814V1Roer0TgMx1cre1Cgn0TgMx1cre1CgnTgKitD814V1Roer